Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms.

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

Soluble guanylate cyclase purified from bovine lung contains heme and copper

1981 • 328 citations

Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation.

1978 • 327 citations

Activation of purified guanylate cyclase by nitric oxide requires heme comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung

1982 • 262 citations

Nitrosylmetalloporphyrins. II. Synthesis and molecular stereochemistry of nitrosyl-.alpha.,.beta.,.gamma.,.delta.-tetraphenylporphinatoiron(II)

1975 • 228 citations

Influence of globin structures on the state of the heme. IV. Ferrous low spin derivatives

1976 • 228 citations

Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins.

1984 • 220 citations

Activation of purified soluble guanylate cyclase by protoporphyrin IX.

1982 • 206 citations

Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme.

1982 • 182 citations

Electron paramagnetic resonance studies of nitrosyl ferrous heme complexes. Determination of an equilibrium between two conformations.

1980 • 142 citations

Purification and properties of heme-deficient hepatic soluble guanylate cyclase: Effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX

1982 • 107 citations

Requirement for heme in the activation of purified guanylate cyclase by nitric oxide

1983 • 96 citations

Electron spin resonance study of the role of NO . catalase in the activation of guanylate cyclase by NaN3 and NH2OH. Modulation of enzyme responses by heme proteins and their nitrosyl derivatives.

1979 • 96 citations

Evidence that regulation of hepatic guanylate cyclase activity involves interactions between catalytic site SH groups and both substrate and activator

1981 • 69 citations

The separation of the heme and apoheme forms of soluble guanylate cyclase

1982 • 57 citations

Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes.

1984 • 45 citations

Selective alterations in responsiveness of guanylate cyclase to activation by nitroso compounds during enzyme purification

1981 • 36 citations

Activation of hepatic guanylate cyclase by nitrosyl-heme complexes

1981 • 17 citations