Evidence that nitric oxide is an endogenous antiangiogenic mediator

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Angiogenesis.

1992 • 2,581 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Laminin–a glycoprotein from basement membranes.

1979 • 2,372 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

1988 • 1,209 citations

Tumor Angiogenesis

1985 • 1,038 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

Biological Roles of Nitric Oxide

1992 • 731 citations

Activation of blood coagulation in cancer: Trousseau's syndrome revisited

1983 • 676 citations

Activation of blood coagulation in cancer: Trousseau's syndrome revisited

1983 • 590 citations

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

1983 • 589 citations

A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

1983 • 368 citations

Correlation between thrombin-induced prostacyclin production and inositol trisphosphate and cytosolic free calcium levels in cultured human endothelial cells.

1987 • 281 citations

Nitric oxide synthesized from L‐arginine regulates vascular tone in the coronary circulation of the rabbit

1989 • 279 citations

Thrombin structure and function

1991 • 250 citations

Inhibition by nitric oxide and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells

1990 • 239 citations

NO^•, CO and ^•OH Endogenous soluble guanylyl cyclase‐activating factors

1992 • 192 citations

Interleukln-8 stimulates angiogenesis in rats

1993 • 182 citations

Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators

1989 • 166 citations

Thrombin promotes angiogenesis by a mechanism independent of fibrin formation

1993 • 114 citations

Nitric oxide is involved in the regulation of angiogenesis

1993 • 105 citations

Glucocorticoids as cytokine inhibitors: role in neuroendocrine control and therapy of inflammatory diseases

1993 • 74 citations

Rate of basement membrane biosynthesis as an index to angiogenesis

1988 • 73 citations

The involvement of platelets in non-thrombotic processes

1988 • 73 citations

Neovascular responses induced by cultured aortic endothelial cells

1983 • 68 citations

Factors influencing blood supply in wound granuloma quantitated by a new in vivo technique.

1989 • 58 citations

Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells

1991 • 58 citations

Dexamethasone reduces vascular density and plasminogen activator activity in 9L rat brain tumors

1993 • 57 citations

Evidence for the involvement of both ATP and nitric oxide in non‐adrenergic, non‐cholinergic inhibitory neurotransmission in the rabbit portal vein

1993 • 51 citations

Protein Kinase C Involvement in the Regulation of Angiogenesis

1993 • 45 citations

Characterization of the Thrombin-Induced Contraction of Vascular Smooth Muscle

1984 • 43 citations

Synergism between the contractile effect of epidermal growth factor and that of des‐Arg⁹‐bradykinin or of α.‐thrombin in rabbit aortic rings

1992 • 42 citations

Steroid Inhibition of Neural Micro vessel Morphogenesis In Vitro: Receptor Mediation and Astroglial Dependence

1992 • 40 citations

Antiangiogenic action of heparin plus cortisone is associated with decreased collagenous protein synthesis in the chick chorioallantoic membrane system.

1989 • 37 citations

Annual of Cardiac Surgery

1992 • 32 citations

Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets

1989 • 32 citations

Inhibition of inositol 1,4,5‐trisphosphate formation by cyclic GMP in cultured aortic endothelial cells of the pig

1991 • 31 citations

Immunovascular communication: activation and deactivation of murine endothelial cell nitric oxide synthase by cytokines

1993 • 28 citations

Platelet activation by diacylglycerol or ionomycin is inhibited by nitroprusside

1991 • 21 citations

[Inhibition of neovascularization and tumor growth by dexamethasone].

1992 • 2 citations