Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

INTERACTIONS BETWEEN DEOXYRIBONUCLEOTIDE AND DNA SYNTHESIS

1988 • 773 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs ¹

1991 • 461 citations

Ribonucleotide Reductase—a Radical Enzyme

1983 • 423 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

1982 • 349 citations

Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols

1980 • 313 citations

Ribonucleotide reductases: amazing and confusing.

1990 • 288 citations

Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells.

1990 • 284 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

A rapid assay for CDP reductase activity in mammalian cell extracts

1970 • 225 citations

An Electron Spin Resonance Study of Some Complexes of Iron, Nitric Oxide, and Anionic Ligands

1965 • 191 citations

IFN-γ-activated macrophages: Detection by electron paramagnetic resonance of complexes between L-Arginine-derived nitric oxide and non-heme iron proteins

1990 • 185 citations

Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages

1984 • 183 citations

FAD and GSH participate in macrophage synthesis of nitric oxide

1990 • 182 citations

A simple method for counting adherent cells: Application to cultured human monocytes, Macrophages and multinucleated giant cells

1983 • 166 citations

Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: Requirement for inducible and constitutive components

1989 • 148 citations

Characterization of the free radical of mammalian ribonucleotide reductase.

1982 • 132 citations

Nucleoside transport in L1210 murine leukemia cells. Evidence for three transporters.

1990 • 86 citations

Enzymatic Regulation of the Radical Content of the Small Subunit of Escherichia coli Ribonucleotide Reductase Involving Reduction of Its Redox Centers

1989 • 80 citations

Nitrosation by stimulated macrophages. Inhibitors, enhancers and substrates

1989 • 78 citations

Tyrosyl free radical formation in the small subunit of mouse ribonucleotide reductase.

1990 • 73 citations

Reduction of the Fe(III)-tyrosyl radical center of Escherichia coli ribonucleotide reductase by dithiothreitol.

1990 • 38 citations

Inhibition of nucleic acid synthesis in ehrlich tumor cells by periodate-oxidized adenosine and adenylic acid

1974 • 30 citations

Purine deoxyribonucleosides counteract effects of hydroxyurea on deoxyribonucleoside triphosphate pools and DNA synthesis

1987 • 28 citations

Studies of N-hydroxy-N'-aminoguanidine derivatives by nitrogen-15 nuclear magnetic resonance spectroscopy and as ribonucleotide reductase inhibitors

1983 • 28 citations

Leukemia L1210 cell lines resistant to ribonucleotide reductase inhibitors.

1988 • 27 citations

Biological Sciences: Hydroxyguanidine—a New Antitumour Drug

1972 • 26 citations

Interactions Between Deoxyribonucleotide And DNA Synthesis

1988 • 24 citations