Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.

Caspases: Enemies Within

1998 • 6,923 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Cancer statistics, 1997

1997 • 2,045 citations

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1997 • 778 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.

1997 • 698 citations

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1998 • 654 citations

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1998 • 640 citations

Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization.

1995 • 490 citations

Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.

1998 • 453 citations

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

1997 • 437 citations

The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.

1998 • 393 citations

The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.

1998 • 313 citations

Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinoma

1991 • 286 citations

Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.

1998 • 244 citations

Loss of the chromosomal region 10q23-25 in prostate cancer.

1995 • 238 citations

Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis.

1996 • 232 citations

The Bcl-2 gene family and apoptosis

1998 • 108 citations

Bcl-2 Suppresses Apoptosis Resulting from Disruption of the NF-κB Survival Pathway☆

1997 • 101 citations

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate

1998 • 99 citations

Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance.

1998 • 90 citations

Localization of metastasis suppressor gene(s) for rat prostatic cancer to the long arm of human chromosome 10

1995 • 61 citations

Chromosome 10 alterations in prostate adenocarcinoma (review).

1998 • 61 citations

Apoptosis induction by E2F-1 via adenoviral-mediated gene transfer results in growth suppression of head and neck squamous cell carcinoma cell lines

1999 • 49 citations