Linking Integrin α6β4-based Cell Adhesion to the Intermediate Filament Cytoskeleton: Direct Interaction between the β4 Subunit and Plectin at Multiple Molecular Sites

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

INTERMEDIATE FILAMENTS: Structure, Dynamics, Function and Disease

1994 • 1,408 citations

PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates.

1994 • 1,043 citations

Protein-protein interactions: methods for detection and analysis

1995 • 812 citations

Cell Surface Receptors for Extracellular Matrix Molecules

1987 • 793 citations

Characterization of bullous pemphigoid antigen: A unique basement membrane protein of stratified squamous epithelia

1981 • 639 citations

Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion.

1991 • 574 citations

Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice

1996 • 539 citations

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

1996 • 496 citations

Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes.

1990 • 486 citations

Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes.

1990 • 462 citations

Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration

1995 • 440 citations

Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton.

1996 • 406 citations

Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.

1990 • 405 citations

Epithelial detachment due to absence of hemidesmosomes in integrin β4 null mice

1996 • 402 citations

Plectin deficiency results in muscular dystrophy with epidermolysis bullosa

1996 • 386 citations

Desmosomes and hemidesmosomes: structure and function of molecular components

1996 • 350 citations

Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.

1990 • 323 citations

Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture

1997 • 317 citations

A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

1989 • 314 citations

Time-Resolved Fluorescence of Lanthanide Probes and Applications in Biotechnology

1987 • 312 citations

Cytoadhesins, Integrins, and Platelets

1988 • 306 citations

Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization.

1996 • 302 citations

The integrin alpha 6 beta 4 is a laminin receptor.

1992 • 299 citations

An Essential Cytoskeletal Linker Protein Connecting Actin Microfilaments to Intermediate Filaments

1996 • 297 citations

Desmosomes and Hemidesmosomes: Constitutive Molecular Components

1990 • 280 citations

Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain.

1990 • 278 citations

Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells.

1990 • 249 citations

Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.

2000 • 241 citations

The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines.

1987 • 237 citations

Time-Resolved Fluorescence of Lanthanide Probes and Applications in Biotechnology

1987 • 233 citations

Identification of a new hemidesmosomal protein, HD1: a major, high molecular mass component of isolated hemidesmosomes.

1992 • 231 citations

Defective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy.

1996 • 227 citations

A function for the integrin alpha 6 beta 4 in the hemidesmosome.

1991 • 225 citations

The α6β1 (VLA-6) and α6β4 protein complexes: tissue distribution and biochemical properties

1990 • 219 citations

Polarized integrin mediates human keratinocyte adhesion to basal lamina.

1990 • 216 citations

Hemidesmosomes: roles in adhesion, signaling and human diseases

1996 • 213 citations

Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.

1995 • 205 citations

Integrin-mediated adhesion and signaling in tumorigenesis

1994 • 203 citations

The desmoplakin carboxyl terminus coaligns with and specifically disrupts intermediate filament networks when expressed in cultured cells.

1992 • 194 citations

Cloning and sequencing of rat plectin indicates a 466-kD polypeptide chain with a three-domain structure based on a central alpha-helical coiled coil.

1991 • 188 citations

Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions.

1996 • 174 citations

Comparative structural analysis of desmoplakin, bullous pemphigoid antigen and plectin: members of a new gene family involved in organization of intermediate filaments

1992 • 169 citations

Comparison of molecularly cloned bullous pemphigoid antigen to desmoplakin I confirms that they define a new family of cell adhesion junction plaque proteins

1991 • 162 citations

Cytoskeleton-associated plectin: in situ localization, in vitro reconstitution, and binding to immobilized intermediate filament proteins.

1988 • 157 citations

Homozygous deletion mutations in the plectin gene (PLEC1) in patients with epidermolysis bullosa simplex associated with late-onset muscular dystrophy

1996 • 149 citations

Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin.

1987 • 144 citations

Regulation of keratinocyte terminal differentiation by integrin-extracellular matrix interactions

1993 • 142 citations

Proteolytic processing of endogenous and recombinant beta 4 integrin subunit.

1992 • 128 citations

Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24).

1996 • 127 citations

The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes.

1993 • 124 citations

Pathology of cytoskeleton of liver cells: Demonstration of mallory bodies (alcoholic hyalin) in murine and human hepatocytes by immunofluorescence microscopy using antibodies to cytokeratin polypeptides from hepatocytes

1981 • 124 citations

Plectin Transcript Diversity: Identification and Tissue Distribution of Variants with Distinct First Coding Exons and Rodless Isoforms

1997 • 121 citations

Expression of plectin mutant cDNA in cultured cells indicates a role of COOH-terminal domain in intermediate filament association.

1993 • 117 citations

Isolation and characterization of hemidesmosomes from bovine corneal epithelial cells

1991 • 108 citations

A homozygous nonsense mutation in the PLEC1 gene in patients with epidermolysis bullosa simplex with muscular dystrophy.

1996 • 97 citations

Structure and hydrodynamic properties of plectin molecules

1987 • 92 citations

IFAP 300 is common to desmosomes and hemidesmosomes and is a possible linker of intermediate filaments to these junctions.

1994 • 92 citations

Identification of plectin in different human cell types and immunolocalization at epithelial basal cell surface membranes

1984 • 88 citations

Polarisation-dependent association of plectin with desmoplakin and the lateral submembrane skeleton in MDCK cells

1997 • 83 citations

Formation of hemidesmosomes in vitro by a transformed rat bladder cell line.

1991 • 81 citations

A minimal region on the integrin β4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells

1997 • 69 citations

Suitability of different silver enhancement methods applied to 1 nm colloidal gold particles: An immunoelectron microscopic study

1991 • 66 citations

Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells.

1997 • 65 citations

A novel hemidesmosomal plaque component: Tissue distribution and incorporation into assembling hemidesmosomes in an in Vitro model

1991 • 63 citations

In vitro induction of ornithine decarboxylase in urinary bladder carcinoma cells.

1981 • 61 citations

The use of silver-enhanced 1-nm gold probes for light and electron microscopic localization of intra- and extracellular antigens in skin.

1992 • 53 citations

Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia.

1997 • 51 citations

A panel of monoclonal antibodies to rat plectin: Distinction by epitope mapping and immunoreactivity with different tissues and cell lines

1994 • 49 citations

The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin β4 subunit

1997 • 39 citations

Hemidesmosomes in the epithelial cell line 804G: Their fate during wound closure, mitosis and drug induced reorganization of the cytoskeleton

1992 • 38 citations

Polarized Expression of HD1: Relationship with the Cytoskeleton in Cultured Human Colonic Carcinoma Cells

1997 • 37 citations

Phorbol ester- and calcium-induced reorganization of 180-kDa bullous pemphigoid antigen on the ventral surface of cultured human keratinocytes as studied by immunofluorescence and immunoelectron microscopy

1992 • 33 citations

Purification of the 230-kD Bullous Pemphigoid Antigen (BP230) from Bovine Tongue Mucosa: Structural Analyses and Assessment of BP230 Tissue Distribution Using a New Monoclonal Antibody

1994 • 14 citations

Immunogold Staining of Intermediate-Sized Filaments of the Vimentin Type in Human Skin: A Postembedding Immunoelectron Microscopic Study

1990 • 11 citations