Release of cAMP Gating by the α6β4 Integrin Stimulates Lamellae Formation and the Chemotactic Migration of Invasive Carcinoma Cells

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

Basement membrane complexes with biological activity

1986 • 1,489 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Mammalian Membrane-bound Adenylyl Cyclases

1995 • 722 citations

Tumor invasion and metastasis: an imbalance of positive and negative regulation.

1991 • 711 citations

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

1997 • 615 citations

cAMP-induced switching in turning direction of nerve growth cones

1997 • 614 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Rho GTPases

1998 • 534 citations

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

1996 • 496 citations

Lysophosphatidic acid: G-protein signalling and cellular responses

1997 • 492 citations

Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase

1996 • 406 citations

Epithelial detachment due to absence of hemidesmosomes in integrin β4 null mice

1996 • 402 citations

Desmosomes and hemidesmosomes: structure and function of molecular components

1996 • 350 citations

Recent Progress in Understanding the Hormonal Regulation of Phosphodiesterases

1995 • 313 citations

N,N-dimethylformamide-induced alteration of cell culture characteristics and loss of tumorigenicity in cultured human colon carcinoma cells.

1979 • 261 citations

The Integrin α6β4 Functions in Carcinoma Cell Migration on Laminin-1 by Mediating the Formation and Stabilization of Actin-containing Motility Structures

1997 • 241 citations

Linking Integrin α6β4-based Cell Adhesion to the Intermediate Filament Cytoskeleton: Direct Interaction between the β4 Subunit and Plectin at Multiple Molecular Sites

1998 • 238 citations

Laminin receptors: achieving specificity through cooperation

1995 • 225 citations

Hemidesmosomes: roles in adhesion, signaling and human diseases

1996 • 213 citations

Elevation of Intracellular cAMP Inhibits RhoA Activation and Integrin-dependent Leukocyte Adhesion Induced by Chemoattractants

1997 • 205 citations

The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation.

1994 • 183 citations

Activation of pp70/85 S6 Kinases in Interleukin-2-Responsive Lymphoid Cells Is Mediated by Phosphatidylinositol 3-Kinase and Inhibited by Cyclic AMP

1995 • 164 citations

Tumor necrosis factor and CD11/CD18 (beta 2) integrins act synergistically to lower cAMP in human neutrophils.

1990 • 151 citations

Activation of the p21 Pathway of Growth Arrest and Apoptosis by the β4 Integrin Cytoplasmic Domain

1995 • 136 citations

A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells.

1996 • 135 citations

The A9 Antigen Associated with Aggressive Human Squamous Carcinoma Is Structurally and Functionally Similar to the Newly Defined Integrin α6β4

1991 • 130 citations

Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell.

1991 • 130 citations

Gating by Cyclic AMP: Expanded Role for an Old Signaling Pathway

1996 • 128 citations

cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness.

1991 • 128 citations

Characterization of the Rolipram-Sensitive, Cyclic AMP-Specific Phosphodiesterases: Identification and Differential Expression of Immunologically Distinct Forms in the Rat Brain

1998 • 115 citations

Regulation of Cytoskeleton Organization and Paxillin Dephosphorylation by cAMP

1996 • 105 citations

Changes in Integrin and E-Cadherin Expression in Neoplastic Versus Normal Thyroid Tissue

1996 • 105 citations

Function of the integrin alpha 6 beta 1 in metastatic breast carcinoma cells assessed by expression of a dominant-negative receptor.

1996 • 91 citations

Integrin αvβ3 Mediates Chemotactic and Haptotactic Motility in Human Melanoma Cells through Different Signaling Pathways

1996 • 91 citations

Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line

1993 • 86 citations

Subcellular Localization of Rolipram-sensitive, cAMP-specific Phosphodiesterases

1998 • 85 citations

Endothelial cell motility, integrin receptor clustering, and microfilament organization are inhibited by agents that increase intracellular cAMP.

1990 • 78 citations

Integrin α6Aβ1 Induces CD81-dependent Cell Motility without Engaging the Extracellular Matrix Migration Substrate

1997 • 67 citations

The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin alpha 6 beta 4.

1991 • 48 citations

Regulation of integrin‐mediated adhesion at focal contacts by cyclic AMP

1993 • 46 citations

INTEGRIN BETA-4 EXPRESSION IN COLORECTAL-CANCER

1994 • 37 citations

Moderate zinc deficiency in rhesus monkeys. An intrinsic defect of neutrophil chemotaxis corrected by zinc repletion.

1991 • 35 citations

Downstream events in mammary gland morphogenesis mediated by reexpression of the alpha2beta1 integrin: the role of the alpha6 and beta4 integrin subunits.

1998 • 32 citations