Treating Neurodegeneration by Modifying Mitochondria: Potential Solutions to a “Complex” Problem

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

2006 • 3,767 citations

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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Mitochondrial free radical generation, oxidative stress, and aging11This article is dedicated to the memory of our dear friend, colleague, and mentor Lars Ernster (1920–1998), in gratitude for all he gave to us.

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

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A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

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A "Silent" Polymorphism in the MDR 1 Gene Changes Substrate Specificity

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Mitochondrial Complex I Deficiency in Parkinson's Disease

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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

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Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

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The Biologic Clock: The Mitochondria?

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Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

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Thiazolidinediones

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Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

The Many Faces of PPARγ

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Mitochondrial Abnormalities in Alzheimer's Disease

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Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

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Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

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Effects of Tocopherol and Deprenyl on the Progression of Disability in Early Parkinson's Disease

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Peroxisome proliferator-activated receptor a target genes

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MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

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Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

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Dietary Intake of Antioxidants and Risk of Alzheimer Disease

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Abnormalities of the electron transport chain in idiopathic parkinson's disease

1989 • 1,067 citations

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

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Effects of Coenzyme Q10 in Early Parkinson Disease

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Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

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Mitochondria take center stage in aging and neurodegeneration

2005 • 934 citations

Mitochondrial role in cell aging

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Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

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Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

2006 • 861 citations

Expanding insights of mitochondrial dysfunction in Parkinson's disease

2006 • 841 citations

Human Catechol- O -Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure

2006 • 829 citations

PPAR and human metabolic disease

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Spastic Paraplegia and OXPHOS Impairment Caused by Mutations in Paraplegin, a Nuclear-Encoded Mitochondrial Metalloprotease

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Oxidative Alterations in Alzheimer's Disease

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Parkinson's disease: A disorder due to nigral glutathione deficiency?

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Mitochondrial defect in Huntington's disease caudate nucleus

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Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

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Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation

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Genetics of Parkinson disease: paradigm shifts and future prospects

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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

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The mitochondrial energy transduction system and the aging process

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Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

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Cytochrome oxidase deficiency in Alzheimer's disease

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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

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Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

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Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

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Alzheimer's disease

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Brain Cytochrome Oxidase in Alzheimer's Disease

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Effectiveness of high‐dose riboflavin in migraine prophylaxis A randomized controlled trial

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Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

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Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

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Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease

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Role of Mitochondria in Oxidative Stress and Aging

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Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin

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Nuclear control of respiratory gene expression in mammalian cells

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Regional Cerebral Metabolic Alterations in Dementia of the Alzheimer Type

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Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo

2005 • 449 citations

A Selective Increase in Particulate Superoxide Dismutase Activity in Parkinsonian Substantia Nigra

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A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease

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Antioxidant Vitamin Intake and Risk of Alzheimer Disease

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Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

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Brain Peroxidase and Catalase in Parkinson Disease

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Bioenergetic and oxidative stress in neurodegenerative diseases

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High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

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Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

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Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

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Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

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Dichloroacetate causes toxic neuropathy in MELAS

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RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

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Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells

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Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease

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Oxidative Damage in Huntington's Disease Pathogenesis

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The development of mitochondrial medicine.

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A clinical trial of creatine in ALS

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Analysis of European mitochondrial haplogroups with Alzheimer disease risk

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Peroxisome Proliferator-Activated Receptors γ and α Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression

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A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis

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Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy

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Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

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Parkin enhances mitochondrial biogenesis in proliferating cells

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Regional Mitochondrial Respiratory Activity in Huntington's Disease Brain

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Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids

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The mitochondrial tRNA(Leu(UUR)) mutation in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS): genetic, biochemical, and morphological correlations in skeletal muscle.

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Oxygen toxicity protecting enzymes in Parkinson's disease

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Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders

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Midlife Dietary Intake of Antioxidants and Risk of Late-Life Incident Dementia: The Honolulu-Asia Aging Study

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Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk

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Evidence for a defect in NADH

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Antioxidant Treatment of Patients With Friedreich Ataxia

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Environment, Mitochondria, and Parkinson's Disease

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Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease

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Mitochondrial Aging: Open Questions^a

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Abnormal brain and muscle energy metabolism shown by ³¹ P magnetic resonance spectroscopy in patients affected by migraine with aura

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Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

2002 • 205 citations

Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients

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Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease

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Creatine supplementation in Parkinson disease: A placebo-controlled randomized pilot trial

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Time‐course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging

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Complex I Defect in muscle from patients with Huntington's disease

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Insulin Resistance Syndrome and Alzheimer Disease: Pathophysiologic Mechanisms and Therapeutic Implications

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Creatine supplementation in Huntington’s disease

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Mitochondrial Oxidative Stress: Physiologic Consequences and Potential for a Role in Aging

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Mitochondrial encephalomyopathy (MELAS): Pathological study and successful therapy with coenzyme Q10 and idebenone

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Peroxisome Proliferator-activated Receptor γ Thiazolidinedione Agonists Increase Glucose Metabolism in Astrocytes

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Protection Against Ischemic Brain Injury by Inhibition of Mitochondrial Oxidative Stress

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Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging

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Idebenone treatment fails to slow cognitive decline in Alzheimer’s disease

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High frequency of mitochondrial complex I mutations in Parkinson’s disease and aging

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Cytochrome C Oxidase in Alzheimer's Disease Brain

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Localization of the Wilson’s disease protein product to mitochondria

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Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies

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Thiazolidinedione Exposure Increases the Expression of Uncoupling Protein 1 in Cultured Human Preadipocytes

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Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population

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Mitochondrial Transcription Factor A in the Maintenance of Mitochondrial DNA

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Mitochondria in Alzheimer's disease

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Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease

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Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson’s disease

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Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease)

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The Thiazolidinedione Pioglitazone Alters Mitochondrial Function in Human Neuron-Like Cells

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Mitochondrial ND5 mutations in idiopathic Parkinson’s disease

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PGC-1α

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Assessment of coenzyme q10 tolerability in huntington's disease

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Coenzyme Q10:A Review of Its Promise as a Neuroprotectant

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The Mitochondrial Myopathy Encephalopathy, Lactic Acidosis with??Stroke-Like Episodes (MELAS) Syndrome

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Mitochondrial DNA as a Cancer Biomarker

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Somatic mitochondrial DNA mutations in single neurons and glia

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Aging and mitochondria

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Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture

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Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes

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Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients

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Inhibition by R(+) or S(–) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH‐SY5Y neuroblastoma

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18F-2-deoxy-2-fluoro-D-glucose as a tracer in the positron emission tomographic study of senile dementia

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Leigh syndrome caused by mitochondrial DNA G13513A mutation: frequency and clinical features in Japan

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Mitochondrial Microheteroplasmy and a Theory of Aging and Age-Related Disease

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Brain glutathione peroxidase in neurodegenerative disorders

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Peroxisome Proliferator-Activated Receptors and Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression

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Human aging brain disorders: Role of antioxidant enzymes

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Disorders of Movement in Leigh Syndrome

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PPARγ agonists as new therapeutic agents for the treatment of Alzheimer's disease

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Effects of dichloroaeetate in three patients with MELAS

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Mutations in mitochondrial‐encoded cytochrome c oxidase subunits I, II, and III genes detected in Alzheimer's disease using single‐strand conformation polymorphism

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Mitochondria‐derived oxidative stress induces a heat shock protein response

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Mutation and intracellular clonal expansion of mitochondrial genomes: two synergistic components of the aging process?

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Serum antioxidant enzyme activity in Parkinson's disease

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Mitochondrial DNA mutations activate programmed cell survival in the mouse heart

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Development of Mitochondrial Gene Replacement Therapy

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How is Mitochondrial Biogenesis Affected in Mitochondrial Disease?

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Correlation of the Clinical Severity of Alzheimer's Disease With an Aberration in Mitochondrial DNA (mtDNA)

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Role of mitochondria in amyotrophic lateral sclerosis

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In VivoEffects of Pioglitazone on Uncoupling Protein-2 and -3 mRNA Levels in Skeletal Muscle of Hyperglycemic KK Mice

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Current opinions in headache pathogenesis: introduction and synthesis

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Huntington's Disease — Making Connections

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Superoxide Dismutase Expression in Parkinson's Disease

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Transcription meets metabolism in neurodegeneration

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Tissue-Specific Effect of Age and Caloric Restriction Diet on Mitochondrial DNA Content

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Is NADH Effective in the Treatment of Parkinson??s Disease?

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Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease

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Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes

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Where and When Do Somatic mtDNA Mutations Occur?

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Endogenous sodium-potassium ATPase inhibition related biochemical cascade in trisomy 21 and Huntington's disease: neural regulation of genomic function.

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