The Thiazolidinedione Pioglitazone Alters Mitochondrial Function in Human Neuron-Like Cells

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 • 3,923 citations

Mitochondrial Dysfunction and Type 2 Diabetes

2005 • 1,950 citations

Thiazolidinediones

2004 • 1,755 citations

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

2006 • 674 citations

Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone: A Preliminary Study

2005 • 584 citations

Cytochrome oxidase deficiency in Alzheimer's disease

1990 • 581 citations

Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

2005 • 539 citations

Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I

2004 • 499 citations

Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo

2005 • 449 citations

Mitochondrial uncoupling proteins in the cns: in support of function and survival

2005 • 353 citations

Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells

2002 • 339 citations

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

2005 • 300 citations

Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key?

2005 • 273 citations

Peroxisome Proliferator-Activated Receptors γ and α Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression

1998 • 272 citations

Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation

2001 • 258 citations

Coordinate Induction of Energy Gene Expression in Tissues of Mitochondrial Disease Patients

1999 • 171 citations

Increase of mitochondrial DNA content and transcripts in early bovine embryogenesis associated with upregulation of mtTFA and NRF1 transcription factors

2005 • 164 citations

Peroxisome Proliferator-activated Receptor γ Thiazolidinedione Agonists Increase Glucose Metabolism in Astrocytes

2003 • 157 citations

Protection Against Ischemic Brain Injury by Inhibition of Mitochondrial Oxidative Stress

2004 • 155 citations

The pharmacokinetics of pioglitazone in patients with impaired renal function

2003 • 141 citations

Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys.

1997 • 139 citations

Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies

2007 • 129 citations

Thiazolidinedione Exposure Increases the Expression of Uncoupling Protein 1 in Cultured Human Preadipocytes

1998 • 129 citations

Mitochondria in Alzheimer's disease

2002 • 122 citations

Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease)

2006 • 114 citations

Pioglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, Attenuates Myocardial Ischemia/Reperfusion Injury in a Rat Model

2003 • 100 citations

Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes

2003 • 82 citations

The Post-translational Modifications of the Nuclear Encoded Subunits of Complex I from Bovine Heart Mitochondria

2005 • 74 citations

Mitochondrial respiratory chain dysfunction, a non-receptor-mediated effect of synthetic PPAR-ligands: biochemical and pharmacological implications

2004 • 71 citations

Quantification of human mitochondrial DNA in a real time PCR

2002 • 70 citations

Peroxisome Proliferator-Activated Receptors and Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression

1998 • 57 citations

PPARγ agonists as new therapeutic agents for the treatment of Alzheimer's disease

2006 • 55 citations

In VivoEffects of Pioglitazone on Uncoupling Protein-2 and -3 mRNA Levels in Skeletal Muscle of Hyperglycemic KK Mice

1998 • 37 citations

Perspective on a pathogenesis and treatment of Alzheimer's disease

2006 • 31 citations

Mitochondrial uncoupling proteins: New insights from functional and proteomic studies

2006 • 23 citations

P2–408: A double–blind, placebo–controlled, 18–month pilot study of the PPAR–gamma agonist pioglitazone in Alzheimer's disease

2006 • 6 citations