A "Silent" Polymorphism in the MDR 1 Gene Changes Substrate Specificity

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

P-glycoprotein: from genomics to mechanism

2003 • 1,024 citations

Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability

2005 • 476 citations

Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translation

1999 • 384 citations

Single-nucleotide polymorphisms can cause different structural folds of mRNA

1999 • 313 citations

Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations

2002 • 281 citations

MDR1 gene polymorphisms and disposition of the P‐glycoprotein substrate fexofenadine

2002 • 250 citations

C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

2002 • 194 citations

MDR1 haplotypes significantly minimize intracellular uptake and transcellular P‐gp substrate transport in recombinant LLC‐PK1 cells

2006 • 176 citations

Saint John's wort: An in vitro analysis of P‐glycoprotein induction due to extended exposure

2001 • 174 citations

Silent mutations affect in vivo protein folding in Escherichia coli

2002 • 171 citations

Functional Characterization of Coding Polymorphisms in the HumanMDR1 Gene Using a Vaccinia Virus Expression System

2002 • 152 citations

The relationship between synonymous codon usage and protein structure

1998 • 136 citations

Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: functional relevance to pharmacokinetics of digoxin.

2002 • 129 citations

Comparison of codon usage measures and their applicability in prediction of microbial gene expressivity

2005 • 124 citations

Functional Characterization of Glycosylation-Deficient Human P-Glycoprotein Using A Vaccinia Virus Expression System

2000 • 114 citations

Studies on the Relationships between the Synonymous Codon Usage and Protein Secondary Structural Units

2000 • 112 citations

Non‐random usage of ‘degenerate’ codons is related to protein three‐dimensional structure

1996 • 92 citations

Superfolding of the Partially Unfolded Core-glycosylated Intermediate of Human P-glycoprotein into the Mature Enzyme Is Promoted by Substrate-induced Transmembrane Domain Interactions

1998 • 87 citations

A Cluster of Three Single Nucleotide Polymorphisms in the 3′-Untranslated Region of Human Glycoprotein PC-1 Gene Stabilizes PC-1 mRNA and Is Associated With Increased PC-1 Protein Content and Insulin Resistance–Related Abnormalities

2001 • 77 citations

Pseudoxanthoma elasticum 2004

2004 • 61 citations

Protein structure and the sequential structure of mRNA: α-Helix and β-sheet signals at the nucleotide level

1996 • 58 citations

A G-to-A transition at the fifth position of intron-32 of the dystrophin gene inactivates a splice-donor site both in vivo and in vitro

2005 • 56 citations

Coordinate Changes in Drug Resistance and Drug-Induced Conformational Transitions in Altered-Function Mutants of the Multidrug Transporter P-Glycoprotein

2001 • 37 citations

Molecular Mechanism of P-glycoprotein Assembly into Cellular Membranes

2002 • 30 citations

The informational context of the third base in amino acid codons

1994 • 27 citations

Cited By (0)

Loading...