Attenuation of Apoptosis Underlies B Lymphocyte Stimulator Enhancement of Humoral Immune Response

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

2005 • 2,216 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

1999 • 1,464 citations

BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth

1999 • 1,316 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

2000 • 1,171 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator

1999 • 1,123 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis

1999 • 721 citations

Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice

2000 • 579 citations

NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis

1999 • 574 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

RelB Is Essential for the Development of Myeloid-Related CD8α− Dendritic Cells but Not of Lymphoid-Related CD8α+ Dendritic Cells

1998 • 443 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Baff Binds to the Tumor Necrosis Factor Receptor–Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population

2000 • 393 citations

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1995 • 380 citations

NF-AT Activation Induced by a CAML-Interacting Member of the Tumor Necrosis Factor Receptor Superfamily

1997 • 377 citations

TALL-1 is a novel member of the TNF family that is down-regulated by mitogens

1999 • 367 citations

Identification and Characterization of a Novel Cytokine, THANK, aTNF Homologue That ActivatesApoptosis, Nuclear Factor-κB, and c-Jun NH2-Terminal Kinase

1999 • 332 citations

Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts

1999 • 322 citations

B Lymphocytes Differentially Use the Rel and Nuclear Factor κB1 (NF-κB1) Transcription Factors to Regulate Cell Cycle Progression and Apoptosis in Quiescent and Mitogen-activated Cells

1998 • 250 citations

Taci Is a Traf-Interacting Receptor for Tall-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation

2000 • 250 citations

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity

2000 • 229 citations

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2.

1996 • 211 citations

Functional and molecular characterization of single, (4‐hydroxy‐3‐nitrophenyl)acetyl (NP)‐specific, IgG₁⁺ B cells from antibody‐secreting and memory B cell pathways in the C57BL/6 immune response to NP

1992 • 159 citations

Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6

1997 • 159 citations

The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily

1998 • 158 citations

Multifocal defects in immune responses in RelB-deficient mice.

1997 • 131 citations

Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in bcl-xL Transgenic Mice

1999 • 110 citations

Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center

1996 • 99 citations

Bcl-2 Obstructs Negative Selection of Autoreactive, Hypermutated Antibody V Regions during Memory B Cell Development

1998 • 98 citations

Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.

1993 • 92 citations

Reversal of EBV Immortalization Precedes Apoptosis in IL-6–Induced Human B Cell Terminal Differentiation

1997 • 61 citations

CD40-CD154 Interactions in B-Cell Signaling

2000 • 61 citations

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