Germinal center reaction

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth

1999 • 1,316 citations

A chemokine-driven positive feedback loop organizes lymphoid follicles

2000 • 1,220 citations

Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells

1999 • 1,149 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

1998 • 762 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities

2000 • 747 citations

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

2000 • 657 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development

1999 • 519 citations

In Vivo–Activated Cd4 T Cells Upregulate Cxc Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines

1999 • 482 citations

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

1999 • 372 citations

In Situ Studies of the Primary Immune Response to (4-Hydroxy-3-Nitrophenyl)Acetyl. V. Affinity Maturation Develops in Two Stages of Clonal Selection

1998 • 349 citations

Mature Follicular Dendritic Cell Networks Depend on Expression of Lymphotoxin β Receptor by Radioresistant Stromal Cells and of Lymphotoxin β and Tumor Necrosis Factor by B Cells

1999 • 314 citations

Germinal Centers without T Cells

2000 • 292 citations

Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers

1999 • 275 citations

DNA polymerase mu (Pol micro), homologous to TdT, could act as a DNA mutator in eukaryotic cells

2000 • 263 citations

B cell memory and the long-lived plasma cell

1999 • 250 citations

A Novel Functional Interaction between Vav and PKCθ Is Required for TCR-Induced T Cell Activation

2000 • 226 citations

Developmental Switches in Chemokine Response Profiles during B Cell Differentiation and Maturation

2000 • 222 citations

SHIP Recruitment Attenuates FcγRIIB-Induced B Cell Apoptosis

1999 • 220 citations

CD19 Regulates Src Family Protein Tyrosine Kinase Activation in B Lymphocytes through Processive Amplification

2000 • 211 citations

Inducible Costimulator Protein (Icos) Controls T Helper Cell Subset Polarization after Virus and Parasite Infection

2000 • 206 citations

Antigen-Specific B Cell Memory

2000 • 170 citations

Fcγ Receptor IIB on Follicular Dendritic Cells Regulates the B Cell Recall Response

2000 • 169 citations

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

1999 • 167 citations

Suppression of Antigen-Specific Th2 Cell-Dependent IgM and IgG1 Production Following Norepinephrine Depletion In Vivo

1999 • 160 citations

Evolution of Antigen-specific T Cell Receptors In Vivo: Preimmune and Antigen-driven Selection of Preferred Complementarity-determining Region 3 (CDR3) Motifs

1999 • 151 citations

Impaired germinal center reaction in mice with short telomeres

2000 • 149 citations

Identification of Murine Germinal Center B Cell Subsets Defined by the Expression of Surface Isotypes and Differentiation Antigens

2000 • 143 citations

Immunization and Infection Change the Number of Recombination Activating Gene (Rag)-Expressing B Cells in the Periphery by Altering Immature Lymphocyte Production

2000 • 135 citations

Age-Dependent Alterations in the Assembly of Signal Transduction Complexes at the Site of T Cell/APC Interaction

2000 • 135 citations

Human Non-Germinal Center B Cell Interleukin (IL)-12 Production Is Primarily Regulated by T Cell Signals CD40 Ligand, Interferon γ, and IL-10: Role of B Cells in the Maintenance of T Cell Responses

1999 • 134 citations

Nonimmunoglobulin Gene Hypermutation in Germinal Center B Cells

1999 • 123 citations

Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in bcl-xL Transgenic Mice

1999 • 110 citations

Induction of Ig Somatic Hypermutation and Class Switching in a Human Monoclonal IgM+ IgD+ B Cell Line In Vitro: Definition of the Requirements and Modalities of Hypermutation

1999 • 99 citations

Toward a Role of Dendritic Cells in the Germinal Center Reaction: Triggering of B Cell Proliferation and Isotype Switching

1999 • 99 citations

Different Mismatch Repair Deficiencies All Have the Same Effects on Somatic Hypermutation

1999 • 96 citations

A Novel B Lymphocyte–Associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3-Kinase

2000 • 94 citations

Mice reconstituted with DNA polymerase β-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

2000 • 94 citations

Cutting Edge: Polycomb Gene Expression Patterns Reflect Distinct B Cell Differentiation Stages in Human Germinal Centers

2000 • 94 citations

Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice

1999 • 81 citations

Identification of a Human Follicular Dendritic Cell Molecule That Stimulates Germinal Center B Cell Growth

2000 • 78 citations

Lymph Node Germinal Centers Form in the Absence of Follicular Dendritic Cell Networks

1999 • 72 citations

Distinct Role of Follicular Dendritic Cells and T Cells in the Proliferation, Differentiation, and Apoptosis of a Centroblast Cell Line, L3055

2000 • 72 citations

Thymocyte Glucocorticoid Resistance Alters Positive Selection and Inhibits Autoimmunity and Lymphoproliferative Disease in MRL-Mice

1998 • 66 citations

Altered Composition of the Immunological Synapse in an Anergic, Age-Dependent Memory T Cell Subset

2000 • 65 citations

Lymphotoxin-α-Dependent Spleen Microenvironment Supports the Generation of Memory B Cells and Is Required for Their Subsequent Antigen-Induced Activation

2000 • 64 citations

Thymocyte Resistance to Glucocorticoids Leads to Antigen-Specific Unresponsiveness Due to “Holes” in the T Cell Repertoire

2000 • 64 citations

The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells

2000 • 56 citations

Alteration at a Single Amino Acid Residue in the T Cell Receptor α Chain Complementarity Determining Region 2 Changes the Differentiation of Naive Cd4 T Cells in Response to Antigen from T Helper Cell Type 1 (Th1) to Th2

2000 • 54 citations

Role of OCA-B in 3′-IgH Enhancer Function

2000 • 53 citations

Contrasting the In Situ Behavior of a Memory B Cell Clone During Primary and Secondary Immune Responses

1999 • 49 citations

Analysis of Immunoglobulin (Ig) Isotype Diversity and Igm/D Memory in the Response to Phenyl-Oxazolone

2000 • 47 citations

B Cell Receptor Engagement and T Cell Contact Induce bcl-6 Somatic Hypermutation in Human B Cells: Identity with Ig Hypermutation

2000 • 41 citations

Single-Cell PCR Analysis of T Helper Cells in Human Lymph Node Germinal Centers

2000 • 33 citations

Antigen-driven selection of TCR In vivo: related TCR alpha-chains pair with diverse TCR beta-chains.

1999 • 27 citations

Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand

1999 • 26 citations

A soluble form of IL-13 receptor alpha 1 promotes IgG2a and IgG2b production by murine germinal center B cells.

1999 • 21 citations

Antigen-Driven Selection of TCR In Vivo: Related TCR α-Chains Pair with Diverse TCR β-Chains

1999 • 21 citations

A Soluble Form of IL-13 Receptor α1 Promotes IgG2a and IgG2b Production by Murine Germinal Center B Cells

1999 • 19 citations

Human tonsillar germinal center T cells are a diverse and widely disseminated population

1999 • 9 citations