Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

Real time quantitative PCR.

1996 • 6,155 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

The role of STATs in transcriptional control and their impact on cellular function

2000 • 1,186 citations

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

1998 • 1,040 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

Serine phosphorylation of STATs

2000 • 873 citations

A conserved docking motif in MAP kinases common to substrates, activators and regulators

2000 • 801 citations

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 ^WAF1/CIP1 Mediated by STAT1

1996 • 796 citations

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

1997 • 612 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

1996 • 529 citations

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

1997 • 508 citations

GAS Elements: A Few Nucleotides with a Major Impact on Cytokine-Induced Gene Expression

1997 • 428 citations

Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

2000 • 412 citations

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

1993 • 411 citations

Immune Response in Stat2 Knockout Mice

2000 • 399 citations

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

1998 • 395 citations

Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.

1989 • 373 citations

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons

1999 • 373 citations

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

1994 • 359 citations

Roles of STAT3 defined by tissue-specific gene targeting

2000 • 341 citations

Signal transduction: hanging on a scaffold

2000 • 341 citations

How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene

2000 • 337 citations

Complex roles of Stat1 in regulating gene expression

2000 • 326 citations

Regulation of c-myc expression by IFN-γ through Stat1-dependent and -independent pathways

2000 • 314 citations

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different signaling pathway

1999 • 263 citations

Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.

1999 • 245 citations

Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter.

1995 • 241 citations

Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation

1998 • 240 citations

Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons

1999 • 226 citations

Negative regulators of cytokine signal transduction

1999 • 224 citations

Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation

1998 • 220 citations

Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-γ target genes

2000 • 200 citations

Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)

1998 • 198 citations

The Rac1/p38 Mitogen-activated Protein Kinase Pathway Is Required for Interferon α-dependent Transcriptional Activation but Not Serine Phosphorylation of Stat Proteins

2000 • 195 citations

Lipopolysaccharide Induces in Macrophages the Synthesis of the Suppressor of Cytokine Signaling 3 and Suppresses Signal Transduction in Response to the Activating Factor IFN-γ

1999 • 191 citations

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2

2000 • 190 citations

Mitogen-activated protein kinase kinase activity is required for the G ₂ /M transition of the cell cycle in mammalian fibroblasts

1999 • 175 citations

p48/STAT-1alpha-containing complexes play a predominant role in induction of IFN-gamma-inducible protein, 10 kDa (IP-10) by IFN-gamma alone or in synergy with TNF-alpha.

1998 • 175 citations

The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein

1996 • 159 citations

The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.

1996 • 156 citations

Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase

1997 • 155 citations

Regulation of LMP2 and TAP1 Genes by IRF-1 Explains the Paucity of CD8+ T Cells in IRF-1−/− Mice

1996 • 152 citations

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

1995 • 150 citations

p48/STAT-1α-Containing Complexes Play a Predominant Role in Induction of IFN-γ-Inducible Protein, 10 kDa (IP-10) by IFN-γ Alone or in Synergy with TNF-α

1998 • 146 citations

Interferon Regulatory Factor 1 Is Required for Mouse Gbp Gene Activation by Gamma Interferon

1995 • 140 citations

STAT3 Is a Serine Kinase Target in T Lymphocytes

1997 • 139 citations

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling

1999 • 131 citations

Transcriptional Responses to Polypeptide Ligands: The JAK-STAT Pathway

1995 • 129 citations

Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.

1991 • 125 citations

Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity

2000 • 122 citations

Transcription factor activity of STAT proteins: structural requirements and regulation by phosphorylation and interacting proteins

1999 • 111 citations

Use of a Selectable Marker Regulated by Alpha Interferon To Obtain Mutations in the Signaling Pathway

1989 • 106 citations

Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

2000 • 101 citations

CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells

1998 • 93 citations

JAKs and STATs branch out

1996 • 85 citations

Activation of Signal Transducers and Activators of Transcription 1 and 3 by Leukemia Inhibitory Factor, Oncostatin-M, and Interferon-γ in Adipocytes

1998 • 85 citations

Physiological significance of STAT proteins: investigations through gene disruption in vivo

1999 • 79 citations

Stat5a Serine Phosphorylation

2000 • 79 citations

Differential Regulation of Constitutive Major Histocompatibility Complex Class I Expression in T and B Lymphocytes

1999 • 71 citations

The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor

1993 • 71 citations

Jak2-Stat5 Interactions Analyzed in Yeast

1998 • 50 citations

Synergistic Induction of the Tap-1 Gene by IFN-γ and Lipopolysaccharide in Macrophages Is Regulated by STAT1

2000 • 48 citations

A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene.

1994 • 33 citations

Interferon-Induced Guanylate-Binding Proteins Lack an N(T)KXD Consensus Motif and Bind GMP in Addition to GDP and GTP

1991 • 33 citations

Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity

2000 • 20 citations

Stat1 combines signals derived from IFN-γ and LPS receptors during macrophage activation

1998 • 2 citations