Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

STATs and Gene Regulation

1997 • 3,927 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1997 • 1,195 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

Nuclear envelope permeability

1975 • 808 citations

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

1997 • 716 citations

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA

1998 • 696 citations

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

1997 • 654 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Protein Sequence Requirements for Function of the Human T-Cell Leukemia Virus Type 1 Rex Nuclear Export Signal Delineated by a Novel In Vivo Randomization-Selection Assay

1996 • 356 citations

The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.

1996 • 320 citations

An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of Ikappa Balpha

1999 • 264 citations

A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1

1999 • 207 citations

Involvement of Proteasomes in Regulating Jak-STAT Pathways upon Interleukin-2 Stimulation

1997 • 133 citations

A Nuclear Localization Signal of Human Aryl Hydrocarbon Receptor Nuclear Translocator/Hypoxia-inducible Factor 1β Is a Novel Bipartite Type Recognized by the Two Components of Nuclear Pore-targeting Complex

1997 • 121 citations

STAT Signaling in the Pathogenesis and Treatment of Cancer

1999 • 115 citations

Evidence for specific nucleocytoplasmic transport pathways used by leucine-rich nuclear export signals

1999 • 96 citations

Regulation of Interferon-α Responsiveness by the Duration of Janus Kinase Activity

1997 • 94 citations

STAT structure and function in signaling

1998 • 91 citations

Interleukin-3–Induced Activation of the JAK/STAT Pathway Is Prolonged by Proteasome Inhibitors

1998 • 73 citations

Dynamic redistribution of STAT1 protein in IFN signaling visualized by GFP fusion proteins

1999 • 72 citations

Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813.

2011 • 13 citations