Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver

Inducible Gene Targeting in Mice

1995 • 1,897 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones

1986 • 1,521 citations

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

1994 • 1,396 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

1991 • 1,019 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions

1998 • 661 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

1998 • 571 citations

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

1993 • 543 citations

Defective inflammatory response in interleukin 6-deficient mice.

1994 • 540 citations

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

1999 • 521 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells.

1987 • 358 citations

Roles of STAT3 defined by tissue-specific gene targeting

2000 • 341 citations

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 310 citations

Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical Applications

1993 • 274 citations

Differential Activation of Acute Phase Response Factor/Stat3 and Stat1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 239 citations

The role of NF-kappa B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6.

1993 • 192 citations

The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements.

1994 • 181 citations

The acute phase response of the liver in inflammation.

1990 • 171 citations

Dual Signaling Role of the Protein Tyrosine Phosphatase SHP-2 in Regulating Expression of Acute-Phase Plasma Proteins by Interleukin-6 Cytokine Receptors in Hepatic Cells

1999 • 170 citations

Interleukin-6-Specific Activation of the C/EBPδ Gene in Hepatocytes Is Mediated by Stat3 and Sp1

1998 • 163 citations

The Human β Fibrinogen Promoter Contains a Hepatocyte Nuclear Factor 1-Dependent Interleukin-6-Responsive Element

1993 • 149 citations

Acute-Phase Response Factor, a Nuclear Factor Binding to Acute-Phase Response Elements, is Rapidly Activated by Interleukin-6 at the Posttranslational Level

1993 • 146 citations

Progress in liver diseases

1991 • 115 citations

Concerted Participation of NF-κB and C/EBP Heteromer in Lipopolysaccharide Induction of Serum Amyloid A Gene Expression in Liver

1995 • 114 citations

Characterization of the IL-6 Responsive Elements in the γ Fibrinogen Gene Promoter

1995 • 103 citations

A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6.

1990 • 93 citations

The cytokine response element of the rat alpha 1-acid glycoprotein gene is a complex of several interacting regulatory sequences.

1990 • 89 citations

Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor.

1994 • 78 citations

Cooperative effects of C/EBP-like and NFxB-like binding sites on rat serum amyloid A1 gene expression in liver cells

1992 • 73 citations

The Carboxyl-terminal Region of STAT3 Controls Gene Induction by the Mouse Haptoglobin Promoter

1997 • 71 citations

Separate Signaling Mechanisms Are Involved in the Control of STAT Protein Activation and Gene Regulation via the Interleukin 6 Response Element by the Box 3 Motif of gp130

1995 • 60 citations

Detection of a Novel Transcription Factor for the Aα Fibrinogen Gene in Response to Interleukin-6

1995 • 53 citations

Influence of endogenous glucocorticoid on endotoxin-induced production of circulating TNF-alpha.

1991 • 52 citations

ROLE OF STAT3 AND C/EBP IN CYTOKINE-DEPENDENT EXPRESSION OF THE MOUSE SERUM AMYLOID P-COMPONENT (SAP) AND C-REACTIVE PROTEIN (CRP) GENES

2000 • 52 citations

IMPAIRED STAT3 ACTIVATION FOLLOWING LOCALIZED INFLAMMATORY STIMULUS IN IL-6-DEFICIENT MICE

1998 • 51 citations

The Signalling Pathways of Interleukin-6 and Gamma Interferon Converge by the Activation of Different Transcription Factors Which Bind to Common Responsive DNA Elements

1994 • 49 citations

Multiple elements within the glucocorticoid regulatory unit of the rat alpha 1-acid glycoprotein gene are recognition sites for C/EBP.

1992 • 49 citations

Structural diversity of murine serum amyloid A genes. Evolutionary implications.

1987 • 45 citations

The rat and human hemopexin genes contain an identical interleukin-6 response element that is not a target of CAAT enhancer-binding protein isoforms.

1994 • 43 citations

The Type II Hemopexin Interleukin-6 Response Element Predominates the Transcriptional Regulation of the Hemopexin Acute-Phase Responsiveness

1995 • 43 citations

Cis- and trans-acting elements required for constitutive and cytokine-regulated expression of the mouse complement C3 gene

1992 • 40 citations

The STAT3-independent Signaling Pathway by Glycoprotein 130 in Hepatic Cells

1999 • 34 citations

A 58-Base-Pair Region of the Human C3 Gene Confers Synergistic Inducibility by Interleukin-1 and Interleukin-6

1990 • 29 citations

Induction of the Mouse Serum Amyloid A3 Gene by Cytokines Requires both C/EBP Family Proteins and a Novel Constitutive Nuclear Factor

1994 • 21 citations

C/EBPbeta is required for the late phases of acute phase genes induction in the liver and for tumour necrosis factor-alpha, but not Interleukin-6, regulation.

1996 • 17 citations

The Cytokine Response Element of the Rat α₁-Acid Glycoprotein Gene Is a Complex of Several Interacting Regulatory Sequences

1990 • 12 citations

Structure of the Mouse Serum Amyloid A 5 (Saa5) Gene: Relationship to Other Members of the Serum Amyloid A Family

1997 • 5 citations