Pivotal Role of Signal Transducer and Activator of Transcription (Stat)4 and Stat6 in the Innate Immune Response during Sepsis

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES

1999 • 2,766 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Anti-Inflammatory Cytokines

2000 • 1,613 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

Laboratory models of sepsis and septic shock

1990 • 539 citations

Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production

1998 • 458 citations

[45] Measurement of O2− production by human neutrophils. The preparation and assay of NADPH oxidase-containing particles from human neutrophils

1984 • 359 citations

Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice

1998 • 314 citations

STAT family of transcription factors in cytokine-mediated biological responses

2000 • 311 citations

The biology of Stat4 and Stat6

2000 • 310 citations

Role of Cytokines in Sepsis

1997 • 293 citations

Endogenous IL-10 protects mice from death during septic peritonitis.

1995 • 287 citations

STCP-1 (MDC) CC Chemokine Acts Specifically on Chronically Activated Th2 Lymphocytes and Is Produced by Monocytes on Stimulation with Th2 Cytokines IL-4 and IL-13

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Mouse Monocyte-Derived Chemokine Is Involved in Airway Hyperreactivity and Lung Inflammation

1999 • 256 citations

Septic shock

1998 • 255 citations

Clinical Aspects: From Systemic Inflammation to 'Immunoparalysis�

1999 • 237 citations

Endogenous Monocyte Chemoattractant Protein-1 (MCP-1) Protects Mice in a Model of Acute Septic Peritonitis: Cross-Talk Between MCP-1 and Leukotriene B4

1999 • 236 citations

Th2 Cells Are Required for theSchistosoma mansoniEgg-Induced Granulomatous Response

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Women Fight Uphill Battle for Equity

1996 • 213 citations

Human neutrophil-specific granule deficiency: a model to assess the role of neutrophil-specific granules in the evolution of the inflammatory response

1982 • 198 citations

IMMUNE DYSFUNCTION IN MURINE POLYMICROBIAL SEPSIS

1996 • 174 citations

Mechanism of hepatocellular dysfunction during hyperdynamic sepsis

1996 • 160 citations

Th1/Th2 balance in infection

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IMMUNE DYSFUNCTION IN MURINE POLYMICROBIAL SEPSIS

1996 • 124 citations

Expression and Contribution of Endogenous IL-13 in an Experimental Model of Sepsis

2000 • 122 citations

Polymorphonuclear Neutrophils: An Effective Antimicrobial Force

1989 • 110 citations

Increased Susceptibility of Stat4-Deficient and Enhanced Resistance in Stat6-Deficient Mice to Infection withTrypanosoma cruzi

2000 • 108 citations

Pivotal Role of the CC Chemokine, Macrophage-Derived Chemokine, in the Innate Immune Response

2000 • 105 citations

Multiple Roles for IL-12 in a Model of Acute Septic Peritonitis

1999 • 102 citations

Mice withSTAT6-Targeted Gene Disruption Develop a Th1 Response and Control Cutaneous Leishmaniasis

1998 • 84 citations

Dialysate to plasma solute concentration (D/P) versus peritoneal transport parameters in CAPD

1994 • 78 citations

Immunomodulatory Role of C10 Chemokine in a Murine Model of Allergic Bronchopulmonary Aspergillosis

1999 • 71 citations

STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis

1999 • 68 citations

Expression of macrophage-derived chemokine (MDC) mRNA in macrophages is enhanced by interleukin-1 β, tumor necrosis factor α, and lipopolysaccharide

1998 • 66 citations

Intraabdominal infections: Classification, mortality, scoring and pathophysiology

1991 • 52 citations

Chemokine C10 Promotes Disease Resolution and Survival in an Experimental Model of Bacterial Sepsis

2000 • 51 citations

DIVERGENT REGULATION OF THE MURINE CC CHEMOKINE C10 BY Th1AND Th2CYTOKINES

2000 • 30 citations

Liver Perfusion And Hepatocellular Inflammatory Response In Sepsis

1999 • 12 citations