SH2-B Family Members Differentially Regulate JAK Family Tyrosine Kinases

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

STATs and Gene Regulation

1997 • 3,927 citations

Cytokine signal transduction

1994 • 1,358 citations

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

1998 • 1,155 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

1997 • 810 citations

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

2001 • 751 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

Cbl: many adaptations to regulate protein tyrosine kinases

2001 • 621 citations

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

1994 • 599 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

2000 • 412 citations

Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain

2000 • 351 citations

Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1995 • 346 citations

Neuronal differentiation factors/cytokines and synaptic plasticity

1993 • 289 citations

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

1997 • 278 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

Identification and Characterization of Novel Substrates of Trk Receptors in Developing Neurons

1998 • 224 citations

The Janus Protein Tyrosine Kinase Family and Its Role in Cytokine Signaling

1995 • 217 citations

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

1996 • 198 citations

Identification of SH2-Bβ as a Substrate of the Tyrosine Kinase JAK2 Involved in Growth Hormone Signaling

1997 • 175 citations

Mediation of Growth Hormone-dependent Transcriptional Activation by Mammary Gland Factor/Stat 5

1995 • 169 citations

Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2

1995 • 168 citations

Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase.

1995 • 158 citations

The Yeast Tribrid System—Genetic Detection of trans-phosphorylated ITAM-SH2-Interactions

1995 • 157 citations

Identification of SH2-Bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2

1999 • 140 citations

Control of B Cell Production by the Adaptor Protein Lnk

2000 • 135 citations

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

1997 • 129 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Utilize Insulin Receptor Substrate-2 in Intracellular Signaling

1996 • 120 citations

Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two γ-Activated Sites

1995 • 118 citations

Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity

1997 • 118 citations

Identification of Tyrosine Residues in the Intracellular Domain of the Growth Hormone Receptor Required for Transcriptional Signaling and Stat5 Activation

1996 • 114 citations

The APS adapter protein couples the insulin receptor to the phosphorylation of c‐Cbl and facilitates ligand‐stimulated ubiquitination of the insulin receptor

2000 • 102 citations

Identification of the APS Protein as a Novel Insulin Receptor Substrate

1999 • 99 citations

Growth Hormone Stimulates Transcription of the Gene Encoding the Acid-Labile Subunit (ALS) of the Circulating Insulin-Like Growth Factor-Binding Protein Complex and ALS Promoter Activity in Rat Liver

1997 • 98 citations

Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene.

1996 • 92 citations

SH2-Bα is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

1998 • 90 citations

SH2-B Is Required for Nerve Growth Factor-induced Neuronal Differentiation

1999 • 88 citations

Growth Hormone Stimulates the Tyrosine Phosphorylation and Association of p125 Focal Adhesion Kinase (FAK) with JAK2

1998 • 81 citations

SH2-B and APS Are Multimeric Adapters That Augment TrkA Signaling

2001 • 81 citations

APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis

1999 • 81 citations

A Functional DNA Binding Domain Is Required for Growth Hormone-induced Nuclear Accumulation of Stat5B

1999 • 79 citations

Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain

1999 • 79 citations

Janus kinases and their role in growth and disease

1999 • 75 citations

PSM, an Insulin-Dependent, Pro-Rich, PH, SH2 Domain Containing Partner of the Insulin Receptor

1997 • 69 citations

Platelet-derived Growth Factor (PDGF) Stimulates the Association of SH2-Bβ with PDGF Receptor and Phosphorylation of SH2-Bβ

1998 • 65 citations

A STAT Factor Mediates the Sexually Dimorphic Regulation of Hepatic Cytochrome P450 3A10/Lithocholic Acid 6β-Hydroxylase Gene Expression by Growth Hormone

1995 • 65 citations

APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl

1999 • 64 citations

Differential Binding to and Regulation of JAK2 by the SH2 Domain and N-Terminal Region of SH2-Bβ

2000 • 62 citations

APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase

1999 • 60 citations

Growth Hormone (GH) Stimulates Protein Synthesis in Cells Transfected with GH Receptor Complementary DNA

1990 • 56 citations

SH2-B, a Membrane-associated Adapter, Is Phosphorylated on Multiple Serines/Threonines in Response to Nerve Growth Factor by Kinases within the MEK/ERK Cascade

1999 • 47 citations

Growth hormone induces insulin‐like growth factor‐I gene transcription by a synergistic action of STAT5 and HNF‐1α

1999 • 46 citations

Growth hormone induces c-fos and c-jun expression in cells with varying requirements for differentiation.

1992 • 43 citations

Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system

1993 • 40 citations

Molecular Cloning of the Mouse APS as a Member of the Lnk Family Adaptor Proteins

2000 • 38 citations

Growth Hormone-Mediated Regulation of Insulin-Like Growth Factor I Promoter Activity in C6 Glioma Cells*

1999 • 36 citations

Differential Substrate Recognition Capabilities of Janus Family Protein Tyrosine Kinases Within the Interleukin 2 Receptor (I12R) System: Jak3 as a Potential Molecular Target for Treatment of Leukemias with a Hyperactive Jak-Stat Signaling Machinery

1999 • 28 citations