Characterization of Binding of Leukotriene C4 by Human Multidrug Resistance Protein 1

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.

1994 • 777 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

The multidrug resistance protein family

1999 • 654 citations

Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles

1996 • 555 citations

The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes

2000 • 456 citations

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1997 • 432 citations

Structural, mechanistic and clinical aspects of MRP1

1999 • 408 citations

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

1998 • 392 citations

Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP

1998 • 343 citations

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1997 • 326 citations

Functional Multidrug Resistance Protein (MRP1) Lacking the N-terminal Transmembrane Domain

1998 • 318 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

2000 • 267 citations

ATP-dependent 17β-Estradiol 17-(β-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP)

1996 • 265 citations

ATP‐ and glutathione‐dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1

1999 • 256 citations

Human P-Glycoprotein Exhibits Reduced Affinity for Substrates during a Catalytic Transition State

1998 • 247 citations

Modulation of Multidrug Resistance Protein 1 (MRP1/ABCC1) Transport and ATPase Activities by Interaction with Dietary Flavonoids

2001 • 231 citations

Membrane Topology of the Multidrug Resistance Protein (MRP)

1997 • 215 citations

Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein

1995 • 206 citations

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12

1993 • 194 citations

Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily

2001 • 176 citations

Comparison of the Functional Characteristics of the Nucleotide Binding Domains of Multidrug Resistance Protein 1

2000 • 175 citations

Function, evolution and structure of multidrug resistance protein (MRP)

1997 • 168 citations

Reconstitution of ATP-dependent Leukotriene C4 Transport by Co-expression of Both Half-molecules of Human Multidrug Resistance Protein in Insect Cells

1996 • 162 citations

Mutation of a Single Conserved Tryptophan in Multidrug Resistance Protein 1 (MRP1/ABCC1) Results in Loss of Drug Resistance and Selective Loss of Organic Anion Transport

2001 • 160 citations

Transport of the β-O-Glucuronide Conjugate of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1)

2001 • 160 citations

Glutathione Stimulates Sulfated Estrogen Transport by Multidrug Resistance Protein 1

2001 • 159 citations

Both ATP Sites of Human P-Glycoprotein Are Essential but Not Symmetric

1999 • 131 citations

ATP hydrolysis cycles and mechanism inP-glycoprotein and CFTR

1997 • 130 citations

Effects of Lipids on ATPase Activity of Purified Chinese Hamster P-Glycoprotein

1995 • 117 citations

Characterization of the amino-terminal regions in the human multidrug resistance protein (MRP1)

2000 • 113 citations

Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1.

1996 • 106 citations

Nonequivalent Nucleotide Trapping in the Two Nucleotide Binding Folds of the Human Multidrug Resistance Protein MRP1

2000 • 96 citations

Functional Reconstitution of Substrate Transport by Purified Multidrug Resistance Protein MRP1 (ABCC1) in Phospholipid Vesicles

2000 • 95 citations

ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells

1999 • 94 citations

FRET Analysis Indicates That the Two ATPase Active Sites of the P-Glycoprotein Multidrug Transporter Are Closely Associated

2001 • 88 citations

Rhodamine 123 Binds to Multiple Sites in the Multidrug Resistance Protein (MRP1)

2000 • 81 citations

Analysis of the Intron–Exon Organization of the Human Multidrug-Resistance Protein Gene (MRP) and Alternative Splicing of Its mRNA

1997 • 80 citations

Multidrug Resistance Protein

1998 • 80 citations

Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP)

1998 • 74 citations

Identification of a Nonconserved Amino Acid Residue in Multidrug Resistance Protein 1 Important for Determining Substrate Specificity

2001 • 68 citations

Major Photoaffinity Drug Binding Sites in Multidrug Resistance Protein 1 (MRP1) Are within Transmembrane Domains 10–11 and 16–17

2001 • 63 citations

Glutathione-dependent Binding of a Photoaffinity Analog of Agosterol A to the C-terminal Half of Human Multidrug Resistance Protein

2001 • 62 citations

Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells.

1994 • 53 citations

The Multidrug Resistance Protein Is Photoaffinity Labeled by a Quinoline-Based Drug at Multiple Sites

2000 • 36 citations

Direct photoaffinity labeling of leukotriene binding sites

1989 • 34 citations

Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles.

2000 • 18 citations