Functional Reconstitution of Substrate Transport by Purified Multidrug Resistance Protein MRP1 (ABCC1) in Phospholipid Vesicles

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Silver staining of proteins in polyacrylamide gels

1981 • 3,565 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

The multidrug resistance protein family

1999 • 654 citations

MRP3, an organic anion transporter able to transport anti-cancer drugs

1999 • 639 citations

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

1998 • 621 citations

CYSTIC FIBROSIS: GENOTYPIC AND PHENOTYPIC VARIATIONS

1995 • 613 citations

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

1999 • 579 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles

1996 • 555 citations

A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: Application to lens ATPases

1988 • 480 citations

Structural, mechanistic and clinical aspects of MRP1

1999 • 408 citations

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

1998 • 392 citations

Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease

1999 • 351 citations

Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)

1999 • 349 citations

Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.

1987 • 343 citations

Structure of the Multidrug Resistance P-glycoprotein to 2.5 nm Resolution Determined by Electron Microscopy and Image Analysis

1997 • 341 citations

Functional Multidrug Resistance Protein (MRP1) Lacking the N-terminal Transmembrane Domain

1998 • 318 citations

Interactions of the Human Multidrug Resistance Proteins MRP1 and MRP2 with Organic Anions

2000 • 313 citations

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump

1996 • 290 citations

ATP-dependent 17β-Estradiol 17-(β-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP)

1996 • 265 citations

ATPase Activity of the Cystic Fibrosis Transmembrane Conductance Regulator

1996 • 264 citations

Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2.

1997 • 260 citations

ATP‐ and glutathione‐dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1

1999 • 256 citations

Human P-Glycoprotein Exhibits Reduced Affinity for Substrates during a Catalytic Transition State

1998 • 247 citations

The Membrane Lipid Environment Modulates Drug Interactions with the P-Glycoprotein Multidrug Transporter

1999 • 234 citations

Transport Function and Hepatocellular Localization of mrp6 in Rat Liver

2000 • 218 citations

Membrane Topology of the Multidrug Resistance Protein (MRP)

1997 • 215 citations

Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies.

1994 • 196 citations

pABC11 (Also Known as MOAT-C and MRP5), a Member of the ABC Family of Proteins, Has Anion Transporter Activity but Does Not Confer Multidrug Resistance When Overexpressed in Human Embryonic Kidney 293 Cells

1999 • 196 citations

ATP-Dependent Transport of Aflatoxin B₁and Its Glutathione Conjugates by the Product of the Multidrug Resistance Protein (MRP) Gene

1997 • 189 citations

The effects of lipids and detergents on ATPase-active P-glycoprotein

1993 • 186 citations

Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents.

1999 • 178 citations

Comparison of the Functional Characteristics of the Nucleotide Binding Domains of Multidrug Resistance Protein 1

2000 • 175 citations

Reconstitution of Drug Transport by Purified P-glycoprotein

1995 • 172 citations

Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).

2000 • 154 citations

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1992 • 147 citations

Allosteric Interactions between the Two Non-equivalent Nucleotide Binding Domains of Multidrug Resistance Protein MRP1

2000 • 140 citations

How lipids interact with an intrinsic membrane protein: the case of the calcium pump

1998 • 136 citations

ATPase Activity of Purified Multidrug Resistance-associated Protein

1997 • 134 citations

The Effect of Lipid Environment and Retinoids on the ATPase Activity of ABCR, the Photoreceptor ABC Transporter Responsible for Stargardt Macular Dystrophy

2000 • 127 citations

Effects of Lipids on ATPase Activity of Purified Chinese Hamster P-Glycoprotein

1995 • 117 citations

The ABCs of ATP-sensitive potassium channels: more pieces of the puzzle

1997 • 113 citations

Transbilayer Movement of NBD-Labeled Phospholipids in Red Blood Cell Membranes: Outward-Directed Transport by the Multidrug Resistance Protein 1 (MRP1)

1998 • 110 citations

Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1.

1996 • 106 citations

Evidence for a role of the multidrug resistance protein (MRP) in the outward translocation of NBD-phospholipids in the erythrocyte membrane

1998 • 96 citations

Nonequivalent Nucleotide Trapping in the Two Nucleotide Binding Folds of the Human Multidrug Resistance Protein MRP1

2000 • 96 citations

ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells

1999 • 94 citations

Liposome Solubilization and Membrane Protein Reconstitution Using Chaps and Chapso

1997 • 88 citations

Multidrug Resistance Protein

1998 • 80 citations

Monoclonal Antibodies That Inhibit the Transport Function of the 190-kDa Multidrug Resistance Protein, MRP

1999 • 77 citations

The P-glycoprotein multidrug transporter: interactions with membrane lipids, and their modulation of activity

1997 • 56 citations

Purification of the human apical conjugate export pump MRP2

1999 • 40 citations

Functional Reconstitution of the Purified Mannose Phosphotransferase System of Escherichia coli into Phospholipid Vesicles

1995 • 31 citations

Functional Reconstitution of ATP‐Dependent Transporters from the Solubilized Hepatocyte Canalicular Membrane

1994 • 22 citations

Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles.

2000 • 18 citations