ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Silver staining of proteins in polyacrylamide gels

1981 • 3,565 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

1988 • 1,737 citations

Ion motive ATPases. I. Ubiquity, properties, and significance to cell function

1987 • 964 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles

1996 • 555 citations

A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: Application to lens ATPases

1988 • 480 citations

Mechanism of Calcium Transport

1985 • 453 citations

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

1992 • 395 citations

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

1998 • 392 citations

ATPase and Multidrug Transport Activities of the Overexpressed Yeast ABC Protein Yor1p

1998 • 379 citations

Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease

1999 • 351 citations

Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP

1998 • 343 citations

Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.

1987 • 343 citations

Expression of the Gene for Multidrug-Resistance–Associated Protein and Outcome in Patients with Neuroblastoma

1996 • 321 citations

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump

1996 • 290 citations

Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.

1997 • 277 citations

The Two Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Have Distinct Functions in Controlling Channel Activity

1995 • 273 citations

ATP-dependent 17β-Estradiol 17-(β-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP)

1996 • 265 citations

ATPase Activity of the Cystic Fibrosis Transmembrane Conductance Regulator

1996 • 264 citations

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

1993 • 257 citations

ATP‐ and glutathione‐dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1

1999 • 256 citations

PROTON ATPASES: STRUCTURE AND MECHANISM

1983 • 255 citations

Stimulation of rat liver mitochondrial adenosine triphosphatase by anions.

1975 • 253 citations

ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells.

1994 • 235 citations

Multidrug resistance mediated by the multidrug resistance protein (MRP) gene

1996 • 235 citations

Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active

1995 • 226 citations

Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

1993 • 220 citations

Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1995 • 215 citations

Membrane Topology of the Multidrug Resistance Protein (MRP)

1997 • 215 citations

Characterization of the ATPase Activity of Purified Chinese Hamster P-glycoprotein

1994 • 207 citations

Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies.

1994 • 196 citations

ATP-Dependent Transport of Aflatoxin B₁and Its Glutathione Conjugates by the Product of the Multidrug Resistance Protein (MRP) Gene

1997 • 189 citations

The effects of lipids and detergents on ATPase-active P-glycoprotein

1993 • 186 citations

Expression of the multidrug resistance-associated protein (MRP) gene in human cancers.

1995 • 174 citations

Function, evolution and structure of multidrug resistance protein (MRP)

1997 • 168 citations

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1992 • 147 citations

Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1

1997 • 138 citations

ATPase Activity of Purified Multidrug Resistance-associated Protein

1997 • 134 citations

Mechanism of Action of Human P-glycoprotein ATPase Activity

1998 • 118 citations

Effects of Lipids on ATPase Activity of Purified Chinese Hamster P-Glycoprotein

1995 • 117 citations

Unique Enzymes of Purified Microsomes From Pig Fundic Mucosa

1975 • 111 citations

Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1.

1996 • 106 citations

Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein

1997 • 105 citations

Multidrug resistance protein (MRP) expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein.

1997 • 102 citations

Nucleotide Occlusion in the Human Cystic Fibrosis Transmembrane Conductance Regulator

1999 • 95 citations

The ATPase and ATP‐binding functions of P‐glycoprotein

1998 • 89 citations

Monoclonal Antibodies That Inhibit the Transport Function of the 190-kDa Multidrug Resistance Protein, MRP

1999 • 77 citations

Doxorubicin- and Daunorubicin-Glutathione Conjugates, but Not Unconjugated Drugs, Competitively Inhibit Leukotriene C4Transport Mediated byMRP/GS-XPump

1998 • 75 citations

Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport

1997 • 70 citations

Pyrophosphate Stimulates Wild-type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Cl− Channels

1995 • 62 citations

Fluoride is a slow, tight-binding inhibitor of the calcium ATPase of sarcoplasmic reticulum.

1992 • 62 citations

Immunohistochemical detection of DNA topoisomerase IIα, P-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer

1998 • 59 citations

The P-glycoprotein multidrug transporter: interactions with membrane lipids, and their modulation of activity

1997 • 56 citations

Bacterial solute transport proteins in their lipid environment

1993 • 44 citations

Non-equivalent cooperation between the two nucleotide-binding folds of P-glycoprotein

1998 • 38 citations

Coupling of ATP hydrolysis with channel gating by purified, reconstituted CFTR.

1997 • 27 citations

Functional Reconstitution of ATP‐Dependent Transporters from the Solubilized Hepatocyte Canalicular Membrane

1994 • 22 citations

The inhibition of ATP‐dependent shape change of human erythrocyte ghosts correlates with an inhibition of Mg²⁺‐ATPase activity by fluoride and aluminofluoride complexes

1992 • 16 citations