Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

1990 • 1,044 citations

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

1993 • 940 citations

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

1992 • 903 citations

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

1992 • 863 citations

A versatilein vivoandin vitroeukaryotic expression vector for protein engineering

1988 • 686 citations

Hypertriglyceridemia as a Result of Human apo CII Gene Expression in Transgenic Mice

1990 • 540 citations

Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles.

1992 • 458 citations

Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin.

1984 • 436 citations

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III.

1985 • 422 citations

Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo.

1986 • 418 citations

Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.

1980 • 365 citations

Effect of apoproteins on hepatic uptake of triglyceride emulsions in the rat.

1980 • 359 citations

Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate

1975 • 349 citations

Modification of Metabolism and Distribution of Lipids by Ethyl Chlorophenoxyisobutyrate

1962 • 337 citations

Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.

1986 • 328 citations

Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.

1992 • 325 citations

Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver.

1985 • 315 citations

Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia.

1994 • 315 citations

The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

1992 • 312 citations

Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.

1992 • 279 citations

Three Hypolipidemic Drugs Increase Hepatic Palmitoyl-Coenzyme A Oxidation in the Rat

1977 • 262 citations

HEPATIC AND RENAL EFFECTS OF PEROXISOME PROLIFERATORS: BIOLOGICAL IMPLICATIONS*

1982 • 237 citations

Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase.

1987 • 206 citations

Two -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene

1991 • 198 citations

Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif

1987 • 187 citations

Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels.

1994 • 187 citations

Peroxisomes: Biology and Importance in Toxicology and Medicine

2007 • 125 citations

Identification of multiple thyroid hormone response elements located far upstream from the rat S14 promoter.

1990 • 113 citations

Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription

1993 • 110 citations

Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene.

1990 • 110 citations

Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors.

1988 • 110 citations

Increase in Lipoprotein Lipase during Clofibrate Treatment of Hypertriglyceridemia in Patients on Hemodialysis

1979 • 96 citations

Quantitation of human apolipoprotein C-III and its subspecie by radioimmunoassay and analytical isoelectric focusing: abnormal plasma triglyceride-rich lipoprotein apolipoprotein C-III subspecie concentrations in hypertriglyceridemia.

1981 • 87 citations

Effect of hormones on transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat kidney

1985 • 80 citations

Effects of bezafibrate on the serum lipoprotein lipid and apolipoprotein composition, lipoprotein triglyceride removal capacity and the fatty acid composition of the plasma lipid esters

1980 • 79 citations

Peroxisomes

2013 • 77 citations

Lipoproteins and coronary heart disease

1984 • 70 citations

Effects of fibrates on serum lipids and atherosclerosis

1988 • 66 citations

Thyromimetic effect of peroxisomal proliferators in rat liver

1991 • 63 citations

Inhibition of lipid synthesis by beta beta'-tetramethyl-substituted, C14-C22, alpha, omega-dicarboxylic acids in the rat in vivo.

1985 • 62 citations

Synthesis and hypolipidemic and antidiabetogenic activities of .beta.,.beta.,.beta.',.beta.'-tetrasubstituted, long-chain dioic acids

1989 • 50 citations

Apo CIII gene transcription is regulated by a cytokine inducible NF-χB element

1994 • 42 citations

Transcriptional activation by amphipathic carboxylic peroxisomal proliferators is induced by the free acid rather than the acyl‐CoA derivative

1994 • 40 citations

Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats.

1988 • 35 citations

The hypochylomicronemic effect of beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III.

1988 • 25 citations

The effect of β,β'-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III

1994 • 24 citations

Specific repression of transthyretin gene expression in rat liver by a peroxisome proliferator clofibrate

1992 • 24 citations

Tissue selective modulation of redox and phosphate potentials by beta,beta'-methyl-substituted hexadecanedioic acid.

1992 • 21 citations

Clofibrate does not induce peroxisomal proliferation in human hepatoma cell lines PLC/PRF/5 and SK-HEP-1

1987 • 16 citations