Role of peroxisomes in mammalian metabolism

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Peroxisomes (microbodies and related particles).

1966 • 1,635 citations

A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.

1976 • 1,136 citations

Enzymes of Glycerolipid Synthesis in Eukaryotes

1980 • 626 citations

Rat liver peroxisomes catalyze the beta oxidation of fatty acids.

1978 • 608 citations

Metabolic Pathways in Peroxisomes and Glyoxysomes

1981 • 558 citations

Enzymic mechanisms of superoxide production

1991 • 475 citations

Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats.

1979 • 436 citations

Biochemical Mechanisms Of Induction Of Hepatic Peroxisome Proliferation

1989 • 356 citations

GLYCEROLIPID BIOSYNTHESIS IN PEROXISOMES VIA THE ACYL DIHYDROXYACETONE PHOSPHATE PATHWAY*

1982 • 347 citations

Lignoceric acid is oxidized in the peroxisome: implications for the Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy.

1984 • 344 citations

A possible role for plasmalogens in protecting animal cells against photosensitized killing.

1988 • 344 citations

Urate oxidase: primary structure and evolutionary implications.

1989 • 333 citations

Peroxisomal alanine:glyoxylate aminotransferase deficiency in primary hyperoxaluria type I

1986 • 333 citations

Biochemistry of lipids and membranes

1986 • 332 citations

The Metabolic Basis of Inherited Disease

1990 • 302 citations

The biological role of dolichol

1988 • 296 citations

Purification and Properties of Acyl-CoA Oxidase from Rat Liver1

1980 • 252 citations

COMBINED BIOCHEMICAL AND MORPHOLOGICAL STUDY OF PARTICULATE FRACTIONS FROM RAT LIVER

1965 • 250 citations

Cu,Zn superoxide dismutase is a peroxisomal enzyme in human fibroblasts and hepatoma cells.

1991 • 213 citations

Subcellular localization of acyl coenzyme A: dihydroxyacetone phosphate acyltransferase in rat liver peroxisomes (microbodies).

1979 • 194 citations

Peroxisomal βoxidation system of rat liver. Copurification of enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase

1979 • 185 citations

Acyl-CoA synthetase in rat liver peroxisomes. Computer-assisted analysis of cell fractionation experiments.

1980 • 181 citations

Peroxisomal bifunctional protein from rat liver is a trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities.

1990 • 180 citations

Studies on ether phospholipids

1984 • 178 citations

Permeability of the peroxisomal membrane to cofactors of beta-oxidation. Evidence for the presence of a pore-forming protein.

1987 • 172 citations

Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.

1983 • 164 citations

The metabolism of polycyclic hydrocarbons and its relationship to cancer

1978 • 160 citations

Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase.

1987 • 159 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells.

1985 • 158 citations

Purification and Properties of Carnitine Octanoyltransferase and Carnitine Palmitoyltransferase from Rat Liver1

1983 • 149 citations

3-Hydroxy-3-methylglutaryl coenzyme A reductase localization in rat liver peroxisomes and microsomes of control and cholestyramine-treated animals: quantitative biochemical and immunoelectron microscopical analyses.

1986 • 147 citations

Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase.

1992 • 145 citations

The inborn errors of mitochondrial fatty acid oxidation

1987 • 144 citations

Identity of Long-Chain Acyl-Coenzyme A Synthetase of Microsomes, Mitochondria, and Peroxisomes in Rat Liver1

1985 • 135 citations

beta-Oxidation of polyunsaturated fatty acids by rat liver peroxisomes. A role for 2,4-dienoyl-coenzyme A reductase in peroxisomal beta-oxidation.

1986 • 133 citations

Presence of three acyl-CoA oxidases in rat liver peroxisomes. An inducible fatty acyl-CoA oxidase, a noninducible fatty acyl-CoA oxidase, and a noninducible trihydroxycoprostanoyl-CoA oxidase.

1990 • 131 citations

Adrenoleukodystrophy: Impaired oxidation of long chain fatty acids in cultured skin fibroblasts and adrenal cortex

1981 • 130 citations

Free Acetate Production by Rat Hepatocytes during Peroxisomal Fatty Acid and Dicarboxylic Acid Oxidation

1989 • 129 citations

Degradation of unsaturated fatty acids in peroxisomes. Existence of a 2,4-dienoyl-CoA reductase pathway.

1981 • 124 citations

Localization of xanthine oxidase in crystalline cores of peroxisomes. A cytochemical and biochemical study.

1987 • 123 citations

Three-dimensional reconstruction of a peroxisomal reticulum in regenerating rat liver: evidence of interconnections between heterogeneous segments.

1987 • 122 citations

Evidence that peroxisomal acyl-CoA synthetase is located at the cytoplasmic side of the peroxisomal membrane

1982 • 120 citations

Cholesterol synthesis in rat liver peroxisomes. Conversion of mevalonic acid to cholesterol.

1987 • 117 citations

Rat liver dihydroxyacetone-phosphate acyltransferases and their contribution to glycerolipid synthesis.

1984 • 109 citations

Studies on the α Oxidation of Phytanic Acid by Rat Liver Mitochondria

1969 • 108 citations

Properties of purified carnitine acyltransferases of mouse liver peroxisomes.

1984 • 107 citations

Peroxisomal degradation of leukotrienes by beta-oxidation from the omega-end.

1991 • 106 citations

Beta-oxidation of the carboxyl side chain of prostaglandin E2 in rat liver peroxisomes and mitochondria.

1988 • 106 citations

d-Aspartate oxidase, a peroxisomal enzyme in liver of rat and man

1991 • 101 citations

Tissue specificity and species differences in the distribution of urate oxidase in peroxisomes.

1988 • 98 citations

The biological origin of ketotic dicarboxylic aciduria. In vivo and in vitro investigations of the omega-oxidation of C6-C16-monocarboxylic acids in unstarved, starved and diabetic rats.

1981 • 96 citations

Microsomal sn-glycerol 3-phosphate and dihydroxyacetone phosphate acyltransferase activities from liver and other tissues

1977 • 95 citations

The microsomal dicarboxylyl-CoA synthetase

1985 • 90 citations

Identification and purification of a peroxisomal branched chain fatty acyl-CoA oxidase.

1991 • 89 citations

Peroxisomal fatty acid oxidation as detected by H2O2 production in intact perfused rat liver

1981 • 89 citations

Alanine:Cycloserine Antagonism

1965 • 79 citations

Comparison of the carnitine acyltransferase activities from rat liver peroxisomes and microsomes

1976 • 78 citations

Peroxisomes in sebaceous glands

1984 • 77 citations

Distinct long chain and very long chain fatty acyl CoA synthetases in rat liver peroxisomes and microsomes

1988 • 77 citations

Serial section analysis of mouse hepatic peroxisomes

1985 • 74 citations

Implication of a peroxisomal enzyme in the catabolism of glutaryl-CoA

1984 • 74 citations

Compartmentation of dicarboxylic acid β-oxidation in rat liver: importance of peroxisomes in the metabolism of dicarboxylic acids

1989 • 71 citations

Peroxisomal Bile Acid-CoA: Amino-Acid N-Acyltransferase in Rat Liver

1989 • 69 citations

Topographical localization of peroxisomal acyl-CoA ligases: differential localization of palmitoyl-CoA and lignoceroyl-CoA ligases

1990 • 69 citations

Factors influencing palmitoyl-CoA oxidation by rat liver peroxisomal fractions. Substrate concentration, organelle integrity and ATP

1980 • 68 citations

Dehydrogenases of the pentose phosphate pathway in rat liver peroxisomes

1989 • 67 citations

Fatty acid products of peroxisomal β-oxidation

1980 • 65 citations

Cloning and sequence determination of cDNA encoding a second rat liver peroxisomal 3-ketoacyl-CoA thiolase

1990 • 64 citations

L-Pipecolate oxidase: A distinct peroxisomal enzyme in man

1989 • 63 citations

Presence of individual enzymes of cholesterol biosynthesis in rat liver peroxisomes

1990 • 63 citations

In situ metabolism of 1,omega medium chain dicarboxylic acids in the liver of intact rats as detected by 13C and 1H NMR.

1988 • 63 citations

Localization of urate oxidase in the crystalline cores of rat liver peroxisomes by immunocytochemistry and immunoblotting.

1988 • 62 citations

Water- and solute-accessible spaces of purified peroxisomes. Evidence that peroxisomes are permeable to NAD+

1983 • 62 citations

Mitochondrial and peroxisomal beta oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver.

1991 • 60 citations

In vitro formation of bile acids from di- and trihydroxy-5β-cholestanoic acid in human liver peroxisomes

1986 • 59 citations

α-Oxidation of 3-methyl-substituted fatty acids in rat liver

1992 • 58 citations

Redox interactions between catalase and alcohol dehydrogenase pathways of ethanol metabolism in the perfused rat liver.

1990 • 58 citations

Peroxisomes in sebaceous glands

1984 • 57 citations

Inhibition of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid oxidation and of bile acid secretion in rat liver by fatty acids.

1988 • 56 citations

Metabolism of acetyl-CoA by isolated peroxisomal fractions: formation of acetate and acetoacetyl-CoA.

1991 • 55 citations

Atypical riboflavin‐responsive glutaric aciduria, and deficient peroxisomal glutaryl‐CoA oxidase activity: a new peroxisomal disorder

1990 • 55 citations

Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyltransferase I in isolated rat hepatocytes

1992 • 55 citations

Epoxide hydrolase activity in isolated peroxisomes of mouse liver

1983 • 54 citations

Mitochondrial oxidation of phytanic acid in human and monkey liver: Implication that Refsum's disease is not a peroxisomal disorder

1990 • 53 citations

Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver.

1988 • 52 citations

Metabolism of prostaglandin F2 alpha in Zellweger syndrome. Peroxisomal beta-oxidation is a major importance for in vivo degradation of prostaglandins in humans.

1991 • 51 citations

Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver

1989 • 51 citations

Large cation-selective pores from rat liver peroxisomal membranes incorporated to planar lipid bilayers

1986 • 51 citations

Topography of very-long-chain-fatty-acid-activating activity in peroxisomes from rat liver

1991 • 50 citations

Human urate oxidase gene: Cloning and partial sequence analysis reveal a stop codon within the fifth exon

1990 • 50 citations

Purification and characterization of peroxisomal L-pipecolic acid oxidase from monkey liver.

1991 • 49 citations

Formation of chenodeoxycholic acid from 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.

1988 • 49 citations

The subcellular localization of phytanic acid oxidase in rat liver

1987 • 47 citations

Single-channel analysis of a large conductance channel in peroxisomes from rat liver

1989 • 47 citations

Biosynthesis of dolichol by rat liver peroxisomes

1989 • 46 citations

Identification and Characterization of a Novel Epoxide Hydrolase From Mouse Liver Microsomes

1982 • 45 citations

Cellular oxidation of lignoceric acid is regulated by the subcellular localization of lignoceroyl-CoA ligases.

1990 • 44 citations

Studies on the Metabolism of Unsaturated Fatty Acids. XV. Purification and Properties of 2,4-Dienoyl-CoA Reductase from Rat Liver Peroxisomes1

1984 • 42 citations

Subcellular distribution and properties of acyl/alkyl dihydroxyacetone phosphate reductase in rodent livers

1986 • 40 citations

<scp>d</scp>-aspartate oxidase in rat, bovine and sheep kidney cortex is localized in peroxisomes

1989 • 39 citations

Conclusive evidence that very-long-chain fatty acids are oxidized exclusively in peroxisomes in human skin fibroblasts

1991 • 39 citations

Amino Acid Metabolism in Animal Peroxisomes

1987 • 39 citations

Oxidation of oxalate and polyamines by rat peroxisomes.

1985 • 39 citations

Participation of peroxisomes in the metabolism of xenobiotic acyl compounds: comparison between peroxisomal and mitochondrial beta-oxidation of omega-phenyl fatty acids in rat liver.

1987 • 39 citations

Studies on the intracellular distributions of soluble epoxide hydrolase and of catalase by digitonin‐permeabilization of hepatocytes isolated from control and clofibrate‐treated mice

1991 • 38 citations

Epoxide hydrolysis in the cytosol of rat liver, kidney, and testis

1986 • 37 citations

Identification and characterization of a new epoxide hydrolase from mouse liver microsomes.

1983 • 37 citations

Hepatic ethanol metabolism is mediated predominantly by catalase‐H₂O₂ in the fasted state

1988 • 37 citations

Changes in polyamine-oxidizing capacity of peroxisomes under various physiological conditions in rats

1989 • 36 citations

Spontaneous excretion of <scp>d</scp>-alanine in urine in mutant mice lacking <scp>d</scp>-amino-acid oxidase

1989 • 36 citations

Purification of marginal plates from bovine renal peroxisomes: identification with L-alpha-hydroxyacid oxidase B.

1991 • 34 citations

Participation of peroxisomes in the metabolism of xenobiotic acyl compounds: comparison between peroxisomal and mitochondrial β-oxidiation of ω-phenyl fatty acids in rat liver

1987 • 32 citations

The presence of acyl-CoA hydrolase in rat brown-adipose-tissue peroxisomes

1989 • 32 citations

Comparison of Enzymes of Lipid β-Oxidation in Peroxisomes and Mitochondria

1987 • 31 citations

Participation of peroxisomal β-oxidation system in the chain-shortening of a xenobiotic acyl compound

1984 • 31 citations

TOPOGRAPHICAL DISTRIBUTION OF LIPID BIOSYNTHETIC ENZYMES ON PEROXISOMES (MICROBODIES)

1982 • 30 citations

Conjugation of cholic acid with taurine and glycine by rat liver peroxisomes

1986 • 28 citations

Pyrene dodecanoic acid coenzyme A ester: peroxisomal oxidation and chain shortening

1988 • 28 citations

The formation of oxalate from glycolate in rat and human liver

1990 • 27 citations

Identification of mammalian aminotransferases utilizing glyoxylate or pyruvate as amino acceptor. Peroxisomal and mitochondrial asparagine aminotransferase.

1988 • 26 citations

Participation of the peroxisomal β-oxidation system in the chain-shortening of PCA16, a metabolite of the cytosine arabinoside prodrug, YNKO1, in rat liver

1990 • 25 citations

Dihydroxyacetone phosphate acyltransferase and alkyldihydroxyacetone phosphate synthase activities in rat liver subcellular fractions and human skin fibroblasts

1989 • 24 citations

Existence of acetyl-CoA-dependent chain elongation system in hepatic peroxisomes of rat: Effects of clofibrate and di-(2-ethylhexyl)phthalate on the activity

1989 • 24 citations

Liver Peroxisomes and Bile Acid Formation

1987 • 18 citations

Physiological Role of Peroxisomal Beta-Oxidation

1987 • 18 citations

Alkyldihydroxyacetone phosphate synthase mechanism: oxygen-18 studies of fatty acid release from acyldihydroxyacetone phosphate

1985 • 18 citations

Detection of Heat-Stable Δ3, Δ2-Enoyl-CoA Isomerase in Rat Liver Mitochondria and Peroxisomes by Immunochemical Study Using Specific Antibody

1991 • 17 citations

Immunoelectron microscopic localization of the isozymes of L-alpha-hydroxyacid oxidase in renal peroxisomes of beef and sheep: evidence of distinct intraorganellar subcompartmentation.

1991 • 16 citations

C6-C10-dicarboxylic acids in liver and kidney tissue in normal, diabetic ketotic and clofibrate-treated rats

1986 • 16 citations

Dolichol Metabolism and Peroxisomes

1987 • 15 citations

Dolichol Biosynthesis in Rat Liver Peroxisomes.

1987 • 14 citations

The oxidation of dicarboxylic acid CoA esters via peroxisomal fatty acyl-CoA oxidase

1989 • 14 citations

Factors influencing the latency of the peroxisomal enzyme dihydroxyacetone-phosphate acyltransferase (DHAP-AT) in permeabilized human skin fibroblasts

1991 • 13 citations

Subcellular localization of epoxide hydrolase in mouse liver and kidney

1986 • 13 citations

Contribution of peroxisomal β-oxidation system to the chain-shortening of N-(α-methylbenzyl)azelaamic acid in rat liver

1990 • 12 citations

The biogenesis of dicarboxylic acids in rats given hypoglycin

1984 • 11 citations