A highly conserved region in the hormone-binding domain of the human estrogen receptor functions as an efficient transactivation domain in yeast

Gene regulation by steroid hormones

1989 • 3,466 citations

A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

1984 • 2,401 citations

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

[12] High-efficiency transformation of yeast by electroporation

1991 • 798 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

[20] In vitro mutagenesis and plasmid shuffling: From cloned gene to mutant yeast

1991 • 584 citations

Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.

1988 • 530 citations

Genomic organization of the human oestrogen receptor gene.

1988 • 480 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA

1987 • 419 citations

The human oestrogen receptor functions in yeast

1988 • 402 citations

The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins.

1986 • 392 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

KAR1, a gene required for function of both intranuclear and extranuclear microtubules in yeast

1987 • 372 citations

Distinct classes of transcriptional activating domains function by different mechanisms

1990 • 368 citations

Structural Organization and Expression of the Mouse Estrogen Receptor

1987 • 365 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

1990 • 333 citations

Mammalian Glucocorticoid Receptor Derivatives Enhance Transcription in Yeast

1988 • 315 citations

RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo.

1993 • 305 citations

The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific

1989 • 299 citations

Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1

1989 • 247 citations

The chicken progesterone receptor: sequence, expression and functional analysis.

1987 • 236 citations

Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes

1990 • 189 citations

Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.

1992 • 116 citations

Expression of Functional Chicken Oviduct Progesterone Receptors in Yeast (Saccharomyces Cerevisiae)

1989 • 111 citations

An androgen-inducible expression system for Saccharomyces cerevisiae

1991 • 110 citations

The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon.

1989 • 107 citations

Estrogen receptor binding to a DNA response element in vitro is not dependent upon estradiol

1990 • 106 citations

Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast

1992 • 103 citations

Human estrogen receptor regulation in a yeast model system and studies on receptor agonists and antagonists

1992 • 97 citations

Mechanism of estrogen receptor-dependent transcription in a cell-free system.

1990 • 84 citations

Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors.

1993 • 84 citations

In situ distinction between steroid receptor binding and transactivation at a target gene.

1991 • 82 citations

Different TBP-associated factors are required for mediating the stimulation of transcriptionin vitroby the acidic transactivator GAL-VP16 and the two nonacidic activation functions of the estrogen receptor

1993 • 81 citations

The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast

1990 • 80 citations

Steroid-binding domains for regulating the functions of heterologous proteins in cis

1993 • 77 citations

Functional analysis of the human estrogen receptor using a phenotypic transactivation assay in yeast

1992 • 60 citations

Identification of constitutive and steroid-dependent transactivation domains in the mouse oestrogen receptor

1989 • 58 citations

Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast

1992 • 57 citations

Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells.

1992 • 51 citations

Orotidine-5′-phosphate decarboxylase from higher plants

1966 • 38 citations

Expression and Function of the Human Estrogen Receptor in Yeast

1988 • 36 citations

Ligand dependence of estrogen receptor induced changes in chromatin structure

1992 • 31 citations

Isolation of Constitutive Mutations Affecting the Proline Utilization Pathway in Saccharomyces cerevisiae and Molecular Analysis of the PUT3 Transcriptional Activator

1989 • 29 citations

Identification of two regions of the human glucocorticoid receptor hormone binding domain that block activation.

1989 • 23 citations

Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells

1992 • 20 citations

Isolation of constitutive mutations affecting the proline utilization pathway in Saccharomyces cerevisiae and molecular analysis of the PUT3 transcriptional activator.

1989 • 17 citations