An analysis of the role of coenzyme Q in free radical generation and as an antioxidant

Superoxide Dismutase

1969 • 12,578 citations

The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase

1972 • 8,501 citations

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Free radicals and tissue damage produced by exercise

1982 • 1,754 citations

Protein damage and degradation by oxygen radicals. I. general aspects.

1987 • 1,618 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Possible molecular mechanisms of the protonmotive function of cytochrome systems

1976 • 1,252 citations

The Generation of Superoxide Radical during the Autoxidation of Hemoglobin

1972 • 1,162 citations

BIOCHEMISTRY OF OXYGEN TOXICITY

1989 • 1,046 citations

Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine Oxidase

1970 • 1,037 citations

Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.

1991 • 786 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

1974 • 627 citations

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

1990 • 621 citations

Function of Quinones in Energy Conserving Systems

1982 • 596 citations

Respiratory chain linked H₂O₂ production in pigeon heart mitochondria

1971 • 544 citations

Mechanisms of lipid peroxidation

1985 • 542 citations

Do Mitochondria Produce Oxygen Radicals in vivo?

1978 • 530 citations

Succinate-linked diphosphopyridine nucleotide reduction in submitochondrial particles

1963 • 496 citations

Protonmotive redox mechanism of the cytochrome b‐c₁ complex in the respiratory chain: Protonmotive ubiquinone cycle

1975 • 429 citations

Pathological mechanisms in carbon tetrachloride hepatotoxicity

1985 • 422 citations

Free radical formation by antitumor quinones

1989 • 419 citations

The Univalent Reduction of Oxygen by Reduced Flavins and Quinones

1972 • 418 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy.

1989 • 363 citations

Oxygen-derived free radicals and myocardial reperfusion injury: An overview

1991 • 303 citations

NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation

1979 • 293 citations

Superoxide Radical and Hydrogen Peroxide in Mitochondria

1982 • 273 citations

Ubiquinone biosynthesis by the microsomal fraction from rat liver

1987 • 210 citations

The participation of coenzyme Q in free radical production and antioxidation

1990 • 210 citations

[92a] Microsomal lipid peroxidation

1967 • 200 citations

Effect of electron transfer inhibitors on superoxide generation in the cytochrome bc₁ site of the mitochondrial respiratory chain

1983 • 164 citations

A mitochondrial encephalomyopathy: the first case with an established defect at the level of coenzyme Q

1986 • 163 citations

The restoration of DPNH oxidase activity by coenzyme Q (ubiquinone)

1966 • 160 citations

The Effect of Thiols and Disulfides on Water Uptake and Extrusion by Rat Liver Mitochondria

1962 • 155 citations

Treatment of Kearns‐Sayre syndrome with coenzyme Q ₁₀

1986 • 155 citations

The Swelling of Rat Liver Mitochondria by Thyroxine and its Reversal

1959 • 148 citations

Studies on the Mechanism of Swelling, Lysis, and Distintegration of Isolated Liver Mitochondria Exposed to Mixtures of Oxidized and Reduced Glutathione

1964 • 139 citations

Oxygen Radicals Acting as Chemical Messengers: A Hypothesis

1989 • 129 citations

Interaction of ubisemiquinone with a paramagnetic component in heart tissue.

1975 • 128 citations

Endurance training reduces the susceptibility of mouse skeletal muscle to lipid peroxidation in vitro

1983 • 122 citations

Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver.

1990 • 120 citations

Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution

1990 • 118 citations

Tissue coenzyme Q (ubiquinone) and protein concentrations over the life span of the laboratory rat

1985 • 117 citations

Coenzyme Q: Biochemistry, bioenergetics and clinical applications of ubiquinone

1986 • 115 citations

Improvement of abnormal pyruvate metabolism and cardiac conduction defect with coenzyme Q _l0 in Kearns‐Sayre syndrome

1985 • 111 citations

Redox cycling of myoglobin and ascorbate: A potential protective mechanism against oxidative reperfusion injury in muscle

1989 • 108 citations

Clinical and biochemical correlations in mitochondrial myopathies treated with coenzyme Q ₁₀

1988 • 107 citations

Evidence of an ubisemiquinone radical(s) from the NADH-ubiquinone reductase of the mitochondrial respiratory chain.

1983 • 103 citations

Identification of ubiquinone-50 in human neutrophils and its role in microbicidal events.

1982 • 98 citations

Control of succinate dehydrogenase in mitochondria

1971 • 96 citations

Studies with Ubiquinone‐Depleted Submitochondrial Particles

1974 • 93 citations

Properties of a semiquinone anion located in the QH₂:Cytochrome c oxidoreductase segment of the mitochondrial respiratory chain

1980 • 90 citations

Lipid peroxidation in exercise myopathy

1983 • 88 citations

Effect of superoxide dismutase on the autoxidation of various hydroquinones—A possible role of superoxide dismutase as a superoxide: Semiquinone oxidoreductase

1988 • 87 citations

Studies with Ubiquinone‐Depleted Submitochondrial Particles

1970 • 86 citations

Evidence for the production of hydroxyl radicals from the adriamycin semiquinone and H₂O₂

1981 • 83 citations

Diminished inhibition of mitochondrial electron transfer from succinate to cytochrome c by thenoyltrifluoroacetone induced by antimycin.

1979 • 77 citations

Induction of hepatic microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent production of hydrogen peroxide by chronic prior treatment with ethanol.

1973 • 74 citations

Ubisemiquinone in the NADH‐ubiquinone reductase region of the mitochondrial respiratory chain

1989 • 74 citations

Semiquinone Q in the respiratory chain of electron transport particles Electron spin resonance studies

1977 • 74 citations

Coenzyme Q in serum and muscle of 5 patients with Kearns-Sayre syndrome and 12 patients with ophthalmoplegia plus

1989 • 72 citations

Glutathione-dependent reduction of peroxides during ferryl- and met-myoglobin interconversion: A potential protective mechanism in muscle

1989 • 71 citations

Evidence of ubisemiquinone radicals in electron transfer at the cytochromes b and c1 region of the cardiac respiratory chain

1980 • 64 citations

Cytochrome b, flavins, and ubiquinone-50 in enucleated human neutrophils (polymorphonuclear leukocyte cytoplasts).

1984 • 62 citations

Complete amino acid sequence of the ubiquinone binding protein (QP-C), a protein similar to the 14,000-dalton subunit of the yeast ubiquinol-cytochrome c reductase complex.

1985 • 61 citations

Electron spin resonance measurement on ubiquinone-depleted and ubiquinone-replenished submitochondrial particles

1970 • 59 citations

Respiratory chain-linked reduced nicotinamide-adenine dinucleotide dehydrogenase. XXI. Functional organization of the respiratory chain at the dehydrogenase-coenzyme Q junction

1971 • 58 citations

Elevation of tissue coenzyme Q (ubiquinone) and cytochrome c concentrations by endurance exercise in the rat

1984 • 55 citations

Inhibition of microsomal lipid peroxidation by naphthoquinones: Structure-activity relationships and possible mechanisms of action

1985 • 54 citations

Quinones and quinols as inhibitors of lipid peroxidation

1966 • 53 citations

Anti-oxidative effect of coenzyme Q10

1980 • 53 citations

Exercise-induced reversal of age-related declines of oxidative reactions, mitochondrial yield, and flavins in skeletal muscle of the rat

1984 • 50 citations

Comments on the discovery of coenzyme Q: a commentary on “Isolation of a quinone from beef heart mitochondria’ by F.L. Crane, Y. Hatefi, R.L. Lester and C. Widmer Biochim. Biophys. Acta 25 (1957) 220–221

1989 • 46 citations

Inhibition by coenzyme Q of ethanol- and carbon tetrachloride-stimulated lipid peroxidation in vivo and catalyzed by microsomal and mitochondrial systems

1988 • 44 citations

Reduced Nicotinamide Adenine Dinucleotide Phosphate-dependent Lipid Peroxidation by Beef Heart Submitochondrial Particles1

1975 • 38 citations

Recovery time course of ventricular vulnerability after coronary reperfusion in relation to mitochondrial function in ischemic myocardium

1980 • 37 citations

Identification of ubiquinone binding proteins in ubiquinol-cytochrome c reductase by arylazido ubiquinone derivative

1980 • 36 citations

Evidence that a quinone may be required for the production of superoxide and hydrogen peroxide in neutrophils

1981 • 36 citations

Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization

1991 • 35 citations

Effect of thenoyltrifluoroacetone on the interaction of succinate dehydrogenase and cytochrome b in ubiquinone-depleted submitochondrial particles

1971 • 35 citations

The Influence of Age and Endurance Exercise on the Myoglobin Concentration of Skeletal Muscle of the Rat

1984 • 35 citations

Protective effect of endogenous coenzyme Q on both lipid peroxidation and respiratory chain inactivation induced by an adriamycin-iron complex

1987 • 35 citations

Evidence for coenzyme Q function in transplasma membrane electron transport

1990 • 31 citations

Interaction between succinate dehydrogenase and ubiquinone-binding protein from succinate-ubiquinone reductase

1980 • 30 citations

Identification of ubiquinone-binding proteins in yeast mitochondrial ubiquinol-cytochrome c reductase using an azido-ubiquinone derivative

1986 • 28 citations

On the Question of Superoxide Toxicity and the Biological Function of Superoxide Dismutases

1982 • 24 citations

Reaction Pathways of Succinate-Linked Acetoacetate Reduction in Tissue Homogenates and Isolated Mitochondria

1962 • 23 citations

Lipid peroxidation in liver, plasma, and erythrocytes of rats chronically treated with ethanol

1985 • 21 citations

Influence of ubiquinone on the rate of antimycin binding to submitochondrial particles

1972 • 21 citations

Ubiquinone Proteins in Cardiac Mitochondria

1982 • 19 citations

Incorporation of ubiquinones into lipid vesicles and inhibition of lipid peroxidation.

1985 • 19 citations

Effects of Age and Cardiac Work in Vitro on Mitochondrial Oxidative Phosphorylation and (3H)-Leucine Incorporation

1981 • 18 citations

The mechanism of oxidation of reduced nicotinamide dinucleotide phosphate by submitochondrial particles from beef heart

1978 • 18 citations

[55] Extraction and reincorporation of ubiquinone in submitochondrial particles

1978 • 17 citations

Coenzyme Q and Myocardial Function in Aging and Exercise

1985 • 14 citations

Effects of long-term coenzyme Q10 and captopril treatment on survival and functional capacity in rats with experimentally induced heart infarction.

1990 • 14 citations

Effects of free radicals produced by sonolysis on ubiquinone-containing vesicles

1989 • 13 citations

The Role of the Side Chain in the Antioxidant Activity of Ubiquinones

1991 • 11 citations

Influence of coenzyme Q10 on doxorubicin uptake and metabolism by mouse myocardial cells in culture.

1988 • 10 citations

In vitro studies on the OH• and O2−• free radical scavenger properties of idebenone in chemical systems

1990 • 9 citations

Tissue concentrations of coenzyme Q in liver of rats intoxicated by carbon tetrachloride.

1986 • 7 citations

Exercise Training Effects on Mitochondrial Enzyme Activity, Ubiquinones and Vitamin E

1987 • 5 citations

Reactions of oxygen radicals with the quinone ring of coenzyme Q.

1991 • 4 citations