Arsenite induces apoptosis in chinese hamster ovary cells by generation of reactive oxygen species

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water

1992 • 766 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.

1991 • 635 citations

The role of DNA fragmentation in apoptosis

1995 • 608 citations

Oxidative mechanisms in carcinogenesis

1993 • 484 citations

Increased Prevalence of Hypertension and Long-term Arsenic Exposure

1995 • 449 citations

Ingested Inorganic Arsenic and Prevalence of Diabetes Mellitus

1994 • 354 citations

The nature of oxidants and antioxidant systems in the inhibition of mutation and cancer

1988 • 306 citations

Endogenous oxidative damage of deoxycytidine in DNA.

1992 • 280 citations

Atherogenicity and carcinogenicity of high-arsenic artesian well water. Multiple risk factors and related malignant neoplasms of blackfoot disease.

1988 • 279 citations

Oxidative stress-induced apoptosis prevented by trolox

1994 • 266 citations

Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium.

1993 • 187 citations

Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice

1991 • 185 citations

Cadmium induced apoptosis in a human T cell line

1994 • 178 citations

Concurrent exposure to lead, cadmium, and arsenic. Effects on toxicity and tissue metal concentrations in the rat.

1981 • 175 citations

Evidence that desferrioxamine cannot enter cells by passive diffusion

1991 • 164 citations

Apoptosis induced by mild hyperthermia in human and murine tumour cell lines: A study using electron microscopy and DNA gel electrophoresis

1991 • 162 citations

Iron is the intracellular metal involved in the production of DNA damage by oxygen radicals

1991 • 158 citations

Bcl-2: an antidote to programmed cell death.

1992 • 155 citations

Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts

1995 • 149 citations

Transfer of arsenite from glutathione to dithiols: A model of interaction

1993 • 148 citations

The Heat Shock Response in HeLa Cells is Accompanied by Elevated Expression of the c-fos Proto-Oncogene

1987 • 147 citations

Comparative investigations of the genotoxic effects of metals in the single cell gel (SCG) assay and the sister chromatid exchange (SCE) test

1994 • 143 citations

Is the Genotoxic Effect of Arsenic Mediated by Oxygen Free Radicals?

1991 • 141 citations

Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells

1994 • 130 citations

Spectrofluorometric analysis of hydrogen peroxide

1974 • 127 citations

Drug-induced apoptosis is not necessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3.

1995 • 115 citations

The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene.

1987 • 106 citations

Myocardial salvage with trolox and ascorbic acid for an acute evolving infarction

1989 • 103 citations

Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.

1994 • 97 citations

The effects of hydrogen peroxide on DNA repair activities

1995 • 94 citations

Free Radicals and Carcinogenesis

1990 • 92 citations

Activation of rat brain protein kinase C by lipid oxidation products

1988 • 83 citations

Induction of internucleosomal DNA fragmentation by carcinogenic chromate: relationship to DNA damage, genotoxicity, and inhibition of macromolecular synthesis.

1994 • 80 citations

Oxidant-Induced Activation of Protein Kinase C in Uc11mg Cells

1995 • 74 citations

Effect of arsenite on the DNA repair of UV-irradiated Chinese hamster ovary cells

1992 • 73 citations

c-fos mRNA levels are increased by the cellular stressors, heat shock and sodium arsenite.

1988 • 72 citations

Oxidative Stress and Heat Shock Protein Induction in Human Cells

1987 • 58 citations

Involvement of Preferential Formation of Apurinic/Apyrimidinic Sites in Dimethylarsenic-Induced DNA Strand Breaks and DNA-Protein Crosslinks in Cultured Alveolar Epithelial Cells

1995 • 56 citations

Mode of action of iron (III) chelators as antimalarials: I. Membrane permeation properties and cytotoxic activity

1993 • 52 citations

Effects of arsenic on DNA damage and repair in human fetal lung fibroblasts

1994 • 47 citations

Sodium arsenite induces ATP depletion and mitochondrial damage in HeLa cells

1991 • 45 citations

Differential effects of luminol, nickel, and arsenite on the rejoining of ultraviolet light and alkylation‐induced DNA breaks

1994 • 32 citations

Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell variants

1994 • 28 citations

Phospholipid peroxidation in tumor promoter-exposed mouse skin

1994 • 17 citations

Ca2+ transport in isolated mouse liver mitochondria; Role of reductive carboxylation and citrate?

1986 • 5 citations