Evidence against the Generation of Free Hydroxyl Radicals from the Interaction of Copper,Zinc-Superoxide Dismutase and Hydrogen Peroxide

Superoxide Dismutase

1969 • 12,578 citations

Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels

1971 • 11,879 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES

1995 • 3,305 citations

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

Aspects of the Structure, Function, and Applications of Superoxide Dismutas

1987 • 859 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Inactivation of the enzyme

1975 • 777 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

Stoichiometric and site characteristics of the binding of iron to human transferrin.

1978 • 585 citations

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

1996 • 464 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

1987 • 461 citations

Reduction and inactivation of superoxide dismutase by hydrogen peroxide

1974 • 393 citations

Faster superoxide dismutase mutants designed by enhancing electrostatic guidance

1992 • 387 citations

Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide.

1990 • 336 citations

Free radicals and myocardial ischemia: Overview and outlook

1988 • 286 citations

Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.

1994 • 251 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Chemiluminescence and peroxidation

1975 • 249 citations

Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation.

1990 • 242 citations

Enzyme function of copper, zinc superoxide dismutase as a free radical generator.

1993 • 224 citations

Genetics of amyotrophic lateral sclerosis

1996 • 206 citations

Quantitative Measurement of Superoxide Generation Using the Spin Trap 5-(Diethoxyphosphoryl)-5-methyl- 1-pyrroline-N-oxide

1997 • 176 citations

Reversal of the superoxide dismutase reaction

1973 • 175 citations

Metal sites of copper proteins. III. Symmetry of copper in bovine superoxide dismutase and its functional significance

1972 • 157 citations

A Familial Amyotrophic Lateral Sclerosis-associated A4V Cu,Zn-Superoxide Dismutase Mutant Has a Lower K for Hydrogen Peroxide

1997 • 150 citations

Anion Binding to Bovine Erythrocyte Superoxide Dismutase

1972 • 137 citations

Hydroxyl radical production by H2O2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme.

1992 • 134 citations

Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H ₂ O ₂

1998 • 118 citations

Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dimutase-implication for gene dosage effects in down syndrome

1988 • 118 citations

Superoxide dismutase amplifies organismal sensitivity to ionizing radiation

1989 • 116 citations

The enzymatic oxidation of Desferal to a nitroxide free radical

1987 • 111 citations

Hydroperoxide anion, HO2−, is an affinity reagent for the inactivation of yeast Cu,Zn superoxide dismutase: Modification of one histidine per subunit

1983 • 102 citations

Bicarbonate Is Required for the Peroxidase Function of Cu,Zn-Superoxide Dismutase at Physiological pH

1999 • 91 citations

The transition metal-mediated formation of the hydroxyl free radical during the reduction of molecular oxygen by ferredoxin-ferredoxin:NADP+ oxidoreductase.

1988 • 80 citations

Peroxidatic oxidation of catecholamines. A kinetic electron spin resonance investigation using the spin stabilization approach.

1984 • 72 citations

Evidence for the generation of free hydroxyl radicals from certain quinone antitumor antibiotics upon reductive activation in solution

1981 • 69 citations

Interaction of hydrogen peroxide with superoxide dismutase from erythrocytes

1972 • 65 citations

Reactions of Hydrogen Peroxide with Familial Amyotrophic Lateral Sclerosis Mutant Human Copper-Zinc Superoxide Dismutases Studied by Pulse Radiolysis

1998 • 62 citations

On the mechanism of superoxide dismutase reaction of the bovine enzyme with hydrogen peroxide and ferrocyanide

1973 • 59 citations

A comparison of the effects of cyanide, hydrogen peroxide, and phenylglyoxal on eucaryotic and procaryotic Cu,Zn superoxide dismutases

1985 • 53 citations

Electron spin resonance study of spin-trapped azide radicals in aqueous solutions

1980 • 43 citations

The Familial Amyotrophic Lateral Sclerosis-Associated Amino Acid Substitutions E100G, G93A, and G93R Do Not Influence the Rate of Inactivation of Copper- and Zinc-Containing Superoxide Dismutase by H2O2

1998 • 40 citations

Mechanism of Horseradish Peroxidase Catalyzed Epinephrine Oxidation: Obligatory Role of Endogenous O₂^- and H₂O₂

1998 • 37 citations

Spin trapping of hydroxyl in water: decay kinetics for the•OH and adducts to 5,5-dimethyl-1-pyrroline-N-oxide

1983 • 30 citations

Copper,zinc-superoxide dismutase and hydrogen peroxide: A hydroxyl radical generating system

1994 • 26 citations

Crystallographic Study of Azide-inhibited Bovine Cu,Zn Superoxide Dismutase

1994 • 24 citations

Identification and quantitation of free radicals and paramagnetic centers from complex multi-component EPR spectra

1993 • 22 citations

An electron spin resonance study of a novel radical cation produced during the horseradish peroxidase-catalyzed oxidation of tetramethylhydrazine

1982 • 16 citations