Mitochondrial DNA determines the cellular response to cancer therapeutic agents

A model for p53-induced apoptosis

1997 • 2,502 citations

Risk Factors for Doxorubicin-lnduced Congestive Heart Failure

1979 • 2,308 citations

Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 • 828 citations

Anthracycline-Induced Cardiotoxicity

1996 • 754 citations

Adriamycin cardiomyopathy: pathophysiology and prevention

1997 • 311 citations

Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA

1988 • 275 citations

Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage

1998 • 275 citations

Doxorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitro.

1990 • 247 citations

Do mitochondrial DNA fragments promote cancer and aging?

1988 • 224 citations

Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA.

1996 • 202 citations

Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.

1996 • 176 citations

Role of oncogenes in resistance and killing by cancer therapeutic agents

1997 • 167 citations

Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: Evidence for mismatch repair systems in mitochondrial genome

1998 • 156 citations

Differential effects of ethidium bromide on mitochondrial and nuclear DNA synthesis in vivo in cultured mammalian cells

1972 • 139 citations

Oncocytic tumours

1998 • 133 citations

Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.

1996 • 123 citations

Mitochondria-Mediated Cell Injury

1997 • 121 citations

Tumor-forming ability in athymic nude mice of human cell lines devoid of mitochondrial DNA.

1994 • 110 citations

Preferential oxidation of cardiac mitochondrial DNA following acute intoxication with doxorubicin

1997 • 100 citations

Alteration of mitochondrial DNA in human oncocytomas

1989 • 96 citations

Mitochondrial DNA Mutations in Aging, Disease and Cancer

1998 • 91 citations

Mitochondria: beyond oxidative phosphorylation

1995 • 91 citations

Mitochondrial alterations in photodynamic therapy-resistant cells.

1993 • 77 citations

EVALUATION OF PORPHYRIN CHARACTERISTICS REQUIRED FOR PHOTODYNAMIC THERAPY

1992 • 74 citations

Amplification of mitochondrial DNA in acute myeloid leukaemia

1996 • 69 citations

Photodynamic therapy sensitivity is not altered in human tumor cells after abrogation of p53 function.

1999 • 66 citations

Differential expression of the mitochondrial gene cytochrome oxidase ii in benign and malignant breast tissue

1992 • 51 citations

Evidence for association of mitochondrial DNA sequence amplification and nuclear localization in human low-grade gliomas

1996 • 47 citations

EARLY BIOCHEMICAL RESPONSES TO PHOTODYNAMIC THERAPY MONITORED BY NMR SPECTROSCOPY

1987 • 46 citations

Selective loss of mitochondrial DNA after treatment of cells with ditercalinium (NSC 335153), an antitumor bis-intercalating agent.

1988 • 45 citations

Increased sensitivity to cis-diamminedichloroplatinum induced apoptosis with mitochondrial DNA depletion

1998 • 43 citations

Nitrogen-fixing root nodules in Ulmaceae

1978 • 33 citations

Mitochondria are the functional intracellular target for a photosensitizing boronated porphyrin

1996 • 32 citations

[35] Automated sequencing of mitochondrial DNA

1996 • 27 citations

Mitochondrial DNA Replication

1998 • 21 citations

Inhibition of Pgp activity and cell cycle-dependent chemosensitivity to doxorubicin in the multidrug-resistant LoVo human colon cancer cell line

1996 • 21 citations

Mitochondria Make A Comeback

1999 • 19 citations

Mitochondrial Regulation of Apoptosis

1998 • 15 citations

Failure of HPV E6 to rapidly degrade p53 in human HeLa×PNET cell hybrids

1997 • 11 citations

Adriamycin uptake and metabolism in organotypic culture of A 549 human adenocarcinoma cells according to the exposure time

1990 • 10 citations

Untitled

1997 • 8 citations