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Tissue biomarkers as prognostic variables of cervical cancer

Data up to Jan 2025

Published2012
Citations85
References198
Clinical Trials (1)

Total Citations Per Year

Abstract

References (198)

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Increased Cyclooxygenase-2 Expression Is Associated With Chemotherapy Resistance and Poor Survival in Cervical Cancer Patients

2002 • 159 citations

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2000 • 159 citations

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2007 • 157 citations

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Human papillomavirus genotype as a major determinant of the course of cervical cancer.

1998 • 155 citations

High Cyclooxygenase-2 Expression in Stage IB Cervical Cancer with Lymph Node Metastasis or Parametrial Invasion

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Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy

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Is lymph vascular space involvement an independent prognostic factor in early cervical cancer?

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Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) negatively affect overall survival in carcinoma of the cervix treated with radiotherapy

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Role of Human Papillomavirus Genotype in Prognosis of Early-Stage Cervical Cancer Undergoing Primary Surgery

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Aberrant Expression of the Cell Cycle Associated Proteins TP53, MDM2, p21, p27, cdk4, Cyclin D1, RB, and EGFR in Cervical Carcinomas

1999 • 122 citations

The cell death machinery governed by the p53 tumor suppressor in response to DNA damage

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Increased expression of pAKT is associated with radiation resistance in cervical cancer

2006 • 120 citations

Gene expression in early stage cervical cancer

2008 • 116 citations

Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas

2001 • 115 citations

Overexpression of cyclooxygenase‐2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy

2002 • 113 citations

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2003 • 113 citations

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The cell death machinery governed by the p53 tumor suppressor in response to DNA damage

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miR‐20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells

2012 • 110 citations

Expression of Epidermal Growth Factor Receptor (EGFR) and Activated EGFR Predict Poor Response to (Chemo)radiation and Survival in Cervical Cancer

2009 • 108 citations

Synchronous Coexpression of Epidermal Growth Factor Receptor and Cyclooxygenase-2 in Carcinomas of the Uterine Cervix

2004 • 108 citations

Epidermal growth factor receptor as a biomarker for cervical cancer

2011 • 107 citations

Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or non-squamous cell carcinoma of the cervix: A Gynecologic Oncology Group study

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Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma

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Polymorphism of the pre-miR-146a is associated with risk of cervical cancer in a Chinese population

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Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix

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Phase II study of cisplatin plus cetuximab in advanced, recurrent, and previously treated cancers of the cervix and evaluation of epidermal growth factor receptor immunohistochemical expression: A Gynecologic Oncology Group study

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Vascular endothelial growth factor and prognosis of cervical carcinoma

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Aberrant Expression of Cyclin D1 Is Associated with Poor Prognosis in Early Stage Cervical Cancer of the Uterus

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MicroRNA miR-886-5p inhibits apoptosis by down-regulating Bax expression in human cervical carcinoma cells

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The importance of biological factors (bcl-2, bax, p53, PCNA, MI, HPV and angiogenesis) in invasive cervical cancer

2001 • 85 citations

Correlating EGFR Expression with Receptor-Binding Properties and Internalization of 64Cu-DOTA-Cetuximab in 5 Cervical Cancer Cell Lines

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Prognostic Cell Biological Markers in Cervical Cancer Patients Primarily Treated With (Chemo)radiation: A Systematic Review

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Expression of p27, p21, and p16 protein in early squamous cervical cancer and its relation to prognosis

2003 • 83 citations

Infiltration by immunocompetent cells in early stage invasive carcinoma of the uterine cervix: a prognostic study

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Expression of p21WAF1/CIP1 in adenocarcinoma of the uterine cervix: a possible immunohistochemical marker of a favorable prognosis.

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Cytokine Profile of Cervical Cancer Cells

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The significance of Treg cells in defective tumor immunity

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Identification of a gene‐expression signature for predicting lymph node metastasis in patients with early stage cervical carcinoma

2011 • 75 citations

EFEMP1 expression promotes angiogenesis and accelerates the growth of cervical cancer in vivo

2010 • 73 citations

Increased Cyclooxygenase-2 Expression Is Associated With Chemotherapy Resistance and Poor Survival in Cervical Cancer Patients

2002 • 72 citations

EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target

2011 • 72 citations

Neoadjuvant chemotherapy for locally advanced cervix cancer

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Significance of tumor volume and corpus uteri invasion in cervical cancer patients treated by radiotherapy

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Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer

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The presence of HPV DNA in cervical cancer: Correlation with clinico-pathologic parameters and prognostic significance: 10 years experience at the Department of Obstetrics and Gynecology of the Mainz University

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Prediction of Lymph Node Metastasis in Patients with Endometrioid Endometrial Cancer Using Expression Microarray

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Prognostic relevance of TGF‐β1 and PAI‐1 in cervical cancer

2004 • 63 citations

Expression of p21WAF1/CIP1 in adenocarcinoma of the uterine cervix

1998 • 63 citations

Is Higher Prevalence of Cervical Intraepithelial Neoplasia in Women With Lupus Due to Immunosuppression?

2010 • 63 citations

Correlation between Expression of EGFR and the Prognosis of Patients with Cervical Carcinoma

2002 • 62 citations

Prognostic relevance of carbonic anhydrase-IX in high-risk, early-stage cervical cancer: A Gynecologic Oncology Group study

2009 • 60 citations

Differential regulation of p63 and p73 expression

2003 • 60 citations

Different outcome of invasive cervical cancer associated with high‐risk versus intermediate‐risk HPV genotype

2008 • 58 citations

Assessment of cytotoxic T-lymphocyte phenotype using the specific markers granzyme B and TIA-1 in cervical neoplastic lesions

1997 • 58 citations

Differential cyclooxygenase-2 expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix

2004 • 58 citations

Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma

2009 • 57 citations

Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy

2006 • 56 citations

The expression of EFEMP1 in cervical carcinoma and its relationship with prognosis

2010 • 56 citations

Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy

2007 • 56 citations

Correlation of cervical carcinoma c-erb B-2 oncogene with cell proliferation parameters in patients treated with radiation therapy for cervical carcinoma

1997 • 55 citations

Expression of ΔNp73 and TAp73α Independently Associated with Radiosensitivities and Prognoses in Cervical Squamous Cell Carcinoma

2006 • 49 citations

Abnormal Expression of Epidermal Growth Factor Receptor and c-erbB2 in Squamous Cell Carcinoma of the Cervix: Correlation with Human Papillomavirus and Prognosis

2001 • 48 citations

Epidermal growth factor receptor (EGFR) is not related to the prognosis of cervical cancer

1998 • 48 citations

Autocrine/paracrine erythropoietin signalling promotes JAK/STAT‐dependent proliferation of human cervical cancer cells

2011 • 47 citations

Expression of HER2neu (c-erbB-2) and epidermal growth factor receptor in cervical cancer: prognostic correlation with clinical characteristics, and comparison of manual and automated imaging analysis

2004 • 47 citations

High-Risk Human Papillomavirus Reduces the Expression of MicroRNA-218 in Women with Cervical Intraepithelial Neoplasia

2010 • 44 citations

VEGF polymorphisms in early cervical cancer susceptibility, angiogenesis, and survival

2010 • 44 citations

Overexpression of gelsolin in human cervical carcinoma and its clinicopathological significance

2010 • 44 citations

Randomized Phase III Trial of Sequential Adjuvant Chemoradiotherapy With or Without Erythropoietin Alfa in Patients With High-Risk Cervical Cancer: Results of the NOGGO-AGO Intergroup Study

2011 • 42 citations

Prognostic Role of the Ratio between Cyclooxygenase-2 in Tumor and Stroma Compartments in Cervical Cancer

2004 • 42 citations

P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma

2003 • 40 citations

Correlation Among Six Biologic Factors (p53, p21WAF1, MIB-1, EGFR, HER2, and Bcl-2) and Clinical Outcomes After Curative Chemoradiation Therapy in Squamous Cell Cervical Cancer

2008 • 36 citations

Absence of epidermal growth factor receptor mutations in cervical cancer

2007 • 36 citations

Expression of cyclins, p53, and Ki-67 in cervical squamous cell carcinomas: overexpression of cyclin A is a poor prognostic factor in stage Ib and II disease

2005 • 35 citations

HPV-18 is a poor prognostic factor, unlike the HPV viral load, in patients with stage IB–IIA cervical cancer undergoing radical hysterectomy

2011 • 34 citations

Gene Expression Changes in Cervical Squamous Cell Carcinoma After Initiation of Chemoradiation and Correlation With Clinical Outcome

2008 • 34 citations

Cyclins and proliferation markers in early squamous cervical carcinoma

2004 • 33 citations

Issues in cervical cancer incidence and treatment in HIV

2010 • 31 citations

The role of VEGF-C/D and Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma

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Identification of Genes Associated With Progression and Metastasis of Advanced Cervical Cancers After Radiotherapy by cDNA Microarray Analysis

2009 • 30 citations

Histopathology of cervical precursor lesions and cancer.

2011 • 28 citations

The prognostic impact of cyclin dependent kinase inhibitors p21WAF1, p27Kip1, and p16INK4/MTS1 in adenocarcinomas of the uterine cervix

2003 • 27 citations

Prognostic significance of VEGF expression in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy

2008 • 27 citations

Loss of heterozygosity on chromosome 6p21.2 as a potential marker for recurrence after radiotherapy of human cervical cancer.

2000 • 26 citations

Direct evidence that hydralazine can induce hypoxia in both transplanted and spontaneous murine tumours

1995 • 25 citations

Cyclooxygenase-2 and Epidermal Growth Factor Receptor Expressions in Different Histological Subtypes of Cervical Carcinomas

2007 • 25 citations

Impact of Epidermal Growth Factor Receptor Expression on Disease-Free Survival and Rate of Pelvic Relapse in Patients With Advanced Cancer of the Cervix Treated With Chemoradiotherapy

2010 • 24 citations

Expression of survivin, cyclinD1, p21WAF1, caspase-3 in cervical cancer and its relation with prognosis

2005 • 22 citations

Expression of BDNF, TrkB, and p53 in early-stage squamous cell carcinoma of the uterine cervix

2011 • 22 citations

Chromosome 6p21.2, 18q21.2 and human papilloma virus (HPV) DNA can predict prognosis of cervical cancer after radiotherapy

2001 • 20 citations

Validation of existing prognostic models in patients with early-stage cervical cancer

2009 • 20 citations

Correlation of p53 and Ki‐67 (MIB‐1) expressions with clinicopathological features and prognosis of early stage cervical squamous cell carcinomas

2010 • 20 citations

Pretreatment platelet and hemoglobin levels are neither predictive nor prognostic variables for patients with locally advanced cervical cancer treated with neoadjuvant chemotherapy and radical hysterectomy: a retrospective Italian study.

2010 • 19 citations

Expression of survivin, caspase-3 and p53 in cervical cancer assessed by tissue microarray: correlation with clinicopathology and prognosis.

2010 • 19 citations

DNA Ploidy is Stronger Than Lymph Node Metastasis as Prognostic Factor in Cervical Carcinoma: 10-Year Results of a Prospective Study

2011 • 18 citations

Endocervical Cancer Is Associated with an Increase in the Ligands and Receptors for Transforming Growth Factor-β and a Contrasting Decrease in p27Kip1

2000 • 18 citations

Prevalence of Chlamydia trachomatis and herpes simplex virus 2 in cervical carcinoma associated with human papillomavirus detected in paraffin-sectioned samples.

2009 • 18 citations

Pitfalls in immunohistochemical validation of tumor marker expression — Exemplified in invasive cancer of the uterine cervix

2008 • 17 citations

Mechanisms of gelsolin-dependent and -independent EGF-stimulated cell motility in a human lung epithelial cell line

2005 • 17 citations

Immunohistochemical study of cell cycle-associated proteins in adenocarcinoma of the uterine cervix treated with radiotherapy alone: P53 status has a strong impact on prognosis

2004 • 17 citations

Loss of heterozygosity on chromosomes 2p, 3p, 18q21.3 and 11p15.5 as a poor prognostic factor in stage II and III (FIGO) cervical cancer treated by radiotherapy.

2006 • 15 citations

Pretreatment proliferation parameters do not add predictive power to clinical factors in cervical cancer treated with definitive radiation therapy.

2003 • 15 citations

Oncogene expression and microvessel count in recurrent and nonrecurrent stage Ib squamous cell carcinoma of the cervix.

1999 • 15 citations

Coexpression of cyclooxygenase-2 and thymidine phosphorylase as a prognostic indicator in patients with FIGO stage IIB squamous cell carcinoma of uterine cervix treated with radiotherapy and concurrent chemotherapy

2005 • 13 citations

Evaluation of p27 in Preinvasive and Invasive Malignancies of the Cervix

2002 • 12 citations

Prevalence and clinical relevance of cyclooxygenase-1 and -2 expression in stage IIB cervical adenocarcinoma

2009 • 12 citations

Prognostic value of p53 expression in early stage cervical carcinoma treated by surgery.

2008 • 8 citations

Are Increased Tumor Aneuploidy and Heightened Cell Proliferation Along With Heterogeneity Associated With Patient Outcome for Carcinomas of the Uterine Cervix? A Combined Analysis of Subjects Treated in RTOG 9001 and a Single-Institution Trial

2007 • 7 citations

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