MicroRNA signatures in human cancers

MicroRNAs

2004 • 33,206 citations

The functions of animal microRNAs

2004 • 10,392 citations

MicroRNA expression profiles classify human cancers

2005 • 9,457 citations

Oncomirs — microRNAs with a role in cancer

2006 • 6,877 citations

A microRNA expression signature of human solid tumors defines cancer gene targets

2006 • 5,638 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

Real-time quantification of microRNAs by stem-loop RT-PCR

2005 • 4,707 citations

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

2005 • 4,706 citations

miRBase: microRNA sequences, targets and gene nomenclature

2005 • 4,598 citations

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

2004 • 4,068 citations

MicroRNA Gene Expression Deregulation in Human Breast Cancer

2005 • 4,014 citations

Silencing of microRNAs in vivo with ‘antagomirs’

2005 • 3,846 citations

RAS Is Regulated by the let-7 MicroRNA Family

2005 • 3,637 citations

A microRNA polycistron as a potential human oncogene

2005 • 3,482 citations

miR-15 and miR-16 induce apoptosis by targeting BCL2

2005 • 3,424 citations

Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia

2000 • 3,282 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

2006 • 3,029 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

2005 • 2,530 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

2004 • 2,341 citations

National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment

1996 • 1,906 citations

Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

2005 • 1,895 citations

Identification of hundreds of conserved and nonconserved human microRNAs

2005 • 1,825 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Chronic Lymphocytic Leukemia

2005 • 1,679 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

A germline-specific class of small RNAs binds mammalian Piwi proteins

2006 • 1,629 citations

A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation

2005 • 1,504 citations

A novel class of small RNAs bind to MILI protein in mouse testes

2006 • 1,439 citations

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

2004 • 1,406 citations

MicroRNAs in cell proliferation, cell death, and tumorigenesis

2006 • 1,367 citations

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

2006 • 1,325 citations

Accumulation of miR-155 and BIC RNA in human B cell lymphomas

2005 • 1,324 citations

miRNAs, Cancer, and Stem Cell Division

2005 • 1,313 citations

MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias

2004 • 1,306 citations

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

2005 • 1,253 citations

A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors

2006 • 1,251 citations

Genetic analysis of genome-wide variation in human gene expression

2004 • 1,219 citations

The role of microRNA genes in papillary thyroid carcinoma

2005 • 1,217 citations

Vertebrate MicroRNA Genes

2003 • 1,190 citations

Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues

2005 • 1,145 citations

microRNA target predictions in animals

2006 • 1,093 citations

Extensive modulation of a set of microRNAs in primary glioblastoma

2005 • 1,090 citations

MicroRNA-Cancer Connection: The Beginning of a New Tale

2006 • 1,048 citations

Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

2006 • 1,047 citations

microRNAs exhibit high frequency genomic alterations in human cancer

2006 • 1,029 citations

Involvement of Human Micro-RNA in Growth and Response to Chemotherapy in Human Cholangiocarcinoma Cell Lines

2006 • 970 citations

An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

2004 • 942 citations

Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome

2005 • 939 citations

The colorectal microRNAome

2006 • 934 citations

Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice

2006 • 913 citations

Genomics of microRNA

2006 • 872 citations

Extensive post-transcriptional regulation of microRNAs and its implications for cancer

2006 • 835 citations

A novel class of small RNAs in mouse spermatogenic cells

2006 • 827 citations

Cooperation between oncogenes

1991 • 792 citations

MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors Are Associated With Distinctive Pathologic Features and Clinical Behavior

2006 • 769 citations

Characterization of the piRNA Complex from Rat Testes

2006 • 728 citations

BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas

2005 • 676 citations

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb

2005 • 639 citations

Microarray-based, high-throughput gene expression profiling of microRNAs

2004 • 618 citations

MicroRNA Biogenesis and Cancer

2005 • 613 citations

The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis

2004 • 602 citations

Reduced expression of Dicer associated with poor prognosis in lung cancer patients

2005 • 586 citations

Natural variation in human gene expression assessed in lymphoblastoid cells

2003 • 561 citations

Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes

2006 • 553 citations

The 2004 World Health Organization classification of lung tumors

2005 • 550 citations

Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity

1999 • 539 citations

MicroRNA deregulation in human thyroid papillary carcinomas

2006 • 525 citations

Real-time expression profiling of microRNA precursors in human cancer cell lines

2005 • 506 citations

Rapid Alteration of MicroRNA Levels by Histone Deacetylase Inhibition

2006 • 492 citations

A high-throughput method to monitor the expression of microRNA precursors

2004 • 475 citations

Approaches to microRNA discovery

2006 • 463 citations

MicroRNAs and cancer

2003 • 443 citations

Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs

2005 • 424 citations

MicroRNAs as oncogenes

2005 • 412 citations

Dicer function is essential for lung epithelium morphogenesis

2006 • 408 citations

MicroRNA fingerprints during human megakaryocytopoiesis

2006 • 400 citations

Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia

1999 • 371 citations

Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?

2005 • 370 citations

LNA-modified oligonucleotides mediate specific inhibition of microRNA function

2006 • 368 citations

MicroRNAs in vertebrate development

2005 • 359 citations

miR‐15a and miR‐16‐1 down‐regulation in pituitary adenomas

2005 • 351 citations

MicroRNAs: a developing story

2005 • 320 citations

Molecular Basis of Human B Cell Neoplasia

1985 • 316 citations

Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas

2002 • 300 citations

Richter syndrome

2004 • 272 citations

Molecular basis of human B cell neoplasia

1985 • 244 citations

ATM mutations in B-cell chronic lymphocytic leukemia.

1999 • 242 citations

The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression

2005 • 221 citations

Sizing up miRNAs as cancer genes

2005 • 198 citations

Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells

2005 • 185 citations

Sequence Variations of MicroRNAs in Human Cancer: Alterations in Predicted Secondary Structure Do Not Affect Processing

2006 • 180 citations

Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia.

1990 • 172 citations

Towards the Human Cancer Epigenome: A First Draft of Histone Modifications

2005 • 170 citations

Cancer of unknown primary (CUP)

2005 • 167 citations

Clusters of Internally Primed Transcripts Reveal Novel Long Noncoding RNAs

2006 • 160 citations

Avian bic , a Gene Isolated from a Common Retroviral Site in Avian Leukosis Virus-Induced Lymphomas That Encodes a Noncoding RNA, Cooperates with c- myc in Lymphomagenesis and Erythroleukemogenesis

2002 • 156 citations

TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state

2005 • 145 citations

A Novel Assay for Viral MicroRNA Function Identifies a Single Nucleotide Polymorphism That Affects Drosha Processing

2006 • 142 citations

Abnormal expression of apoptosis‐related genes in haematological malignancies: overexpression of MYC is poor prognostic sign in mantle cell lymphoma

2003 • 105 citations

Genome amplification of single sperm using multiple displacement amplification

2005 • 104 citations

Camels and zebrafish, viruses and cancer: a microRNA update

2005 • 96 citations

Minority Issues in Prostate Disease

2005 • 13 citations