Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

1999 • 8,737 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Regulation of Mammalian O₂Homeostasis by Hypoxia-Inducible Factor 1

1999 • 1,882 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

2000 • 893 citations

Essential role for oncogenic Ras in tumour maintenance

1999 • 880 citations

Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model.

1995 • 791 citations

Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis.

1994 • 680 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.

1996 • 541 citations

Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology.

1993 • 534 citations

How Tumors Become Angiogenic

1996 • 514 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

HUMAN PAPILLOMAVIRUSES

1994 • 470 citations

Reversible Activation of c-Myc in Skin

1999 • 468 citations

Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts.

1993 • 430 citations

The role of vascular endothelial growth factor in pathological angiogenesis

1995 • 419 citations

Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell Line

1997 • 399 citations

c-fos is required for malignant progression of skin tumors

1995 • 353 citations

Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor.

1996 • 350 citations

The von Hippel-Lindau Tumor Suppressor Gene Product Interacts with Sp1 To Repress Vascular Endothelial Growth Factor Promoter Activity

1997 • 345 citations

Vascular Permeability Factor (Vascular Endothelial Growth Factor) Expression and Angiogenesis in Cervical Neoplasia

1995 • 285 citations

Impact of oncogenes in tumor angiogenesis: Mutant K- ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells

1998 • 264 citations

Transforming growth factor-alpha -induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation

1997 • 256 citations

Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis.

1999 • 245 citations

Oncogenes as inducers of tumor angiogenesis

1995 • 241 citations

Transcription from TATA-less promoters: dihydrofolate reductase as a model.

1993 • 241 citations

The Human Papillomavirus Type 16 E6 Gene Alone Is Sufficient To Induce Carcinomas in Transgenic Animals

1999 • 241 citations

Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression.

1996 • 240 citations

Demonstration and characterization of the angiogenic properties of cervical dysplasia.

1994 • 234 citations

Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.

1987 • 230 citations

Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity

1997 • 217 citations

Integration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: Preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames

1987 • 214 citations

Hypoxia-inducible Protein Binding to Vascular Endothelial Growth Factor mRNA and Its Modulation by the von Hippel-Lindau Protein

1996 • 212 citations

Down-regulation of Vascular Endothelial Growth Factor in a Human Colon Carcinoma Cell Line Transfected with an Antisense Expression Vector Specific for c-src

1998 • 204 citations

The Angiopoietins: Yin and Yang in Angiogenesis

1999 • 203 citations

Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice.

1996 • 202 citations

The molecular genetics of cervical carcinoma

1999 • 202 citations

Human Papillomaviruses and Cervical Neoplasia: A Model for Carcinogenesis

2000 • 195 citations

Humanization of a mouse monoclonal antibody that blocks the epidermal growth factor receptor: recovery of antagonistic activity

1997 • 186 citations

VEGF/VPF: The angiogenesis factor found?

1993 • 163 citations

Establishing a Link between Oncogenes and Tumor Angiogenesis

1998 • 148 citations

Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.

1996 • 144 citations

Cross-species comparison of angiogenesis during the premalignant stages of squamous carcinogenesis in the human cervix and K14-HPV16 transgenic mice.

1997 • 126 citations

The significance of atypical vessels and neovascularization in cervical neoplasia

1981 • 123 citations

Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways

1998 • 117 citations

Do HPV-negative cervical carcinomas exist??revisited

1999 • 88 citations

Viral transcription in human keratinocyte cell lines immortalized by human papillomavirus type-16

1991 • 87 citations

Cellular transformation by papilomavirus oncorproteins

1993 • 77 citations

Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16

1992 • 76 citations

p53 represses Sp1 DNA binding and HIV-LTR directed transcription.

1997 • 74 citations

Expression of epidermal growth factor receptor and human papillomavirus E6/E7 proteins in cervical carcinoma cells

1997 • 69 citations

Different Angiogenic Pathways in Human Cervical Cancers

1998 • 64 citations

VEGF mRNA is Stabilized by Ras and Tyrosine Kinase Oncogenes, as well as by UV Radiation—Evidence for Divergent Stabilization Pathways

1997 • 60 citations

Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes.

1997 • 53 citations

DNA-binding activity of papillomavirus proteins

1987 • 51 citations

Transactivation of Prothymosin α and c-mycPromoters by Human Papillomavirus Type 16 E6 Protein

1997 • 50 citations

v-Raf activates transcription of growth-responsive promoters via GC-rich sequences that bind the transcription factor Sp1.

1995 • 46 citations

Activation of the c-fos gene by the HPV16 oncoproteins depends upon the cAMP-response element at -60

1994 • 45 citations

Rat embryo fibroblasts transformed by c-Jun display highly metastatic and angiogenic activities in vivo and deregulate gene expression of both angiogenic and antiangiogenic factors.

1999 • 36 citations

HPV16 E6 Oncoprotein Stimulates the Transforming Growth Factor-β1 Promoter in Fibroblasts through a Specific GC-Rich Sequence

1997 • 33 citations

Convenient Synthesis of Trichloromethyldihydroquinolines and -isoquinolines

1994 • 19 citations