Prognostic relevance of TGF‐β1 and PAI‐1 in cervical cancer

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.

1986 • 443 citations

High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.

1993 • 396 citations

Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity.

2000 • 337 citations

Transforming growth factor β1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer

1998 • 311 citations

Transforming Growth Factor β₁and Recruitment of Macrophages and Mast Cells in Airways in Chronic Obstructive Pulmonary Disease

1998 • 307 citations

Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.

1987 • 263 citations

Cellular immunodeficiency enhances the progression of human papillomavirus‐associated cervical lesions

1994 • 262 citations

RETRACTED: Deficient Smad7 expression: A putative molecular defect in scleroderma

2002 • 247 citations

Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis.

1999 • 245 citations

Papillomaviruses in Human Cancers

2003 • 240 citations

Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion

1998 • 209 citations

Malignant cells, directors of the malignant process: role of transforming growth factor-beta.

2001 • 180 citations

Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer.

1994 • 167 citations

Effects of TGF-β on the immune system: implications for cancer immunotherapy

1999 • 159 citations

Transforming growth factor-? in benign and malignant prostate

1999 • 156 citations

The expression of transforming growth factor-?1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma

1999 • 154 citations

Circulating Serum Levels of Cytokines and Angiogenic Factors in Patients with Cervical Cancer

1998 • 141 citations

Smad4/DPC4 and Smad3 Mediate Transforming Growth Factor-β (TGF-β) Signaling through Direct Binding to a Novel TGF-β-responsive Element in the Human Plasminogen Activator Inhibitor-1 Promoter

1998 • 138 citations

TGF-β1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion

2001 • 123 citations

Regulation of Endothelial Cell Growth, Architecture, and Matrix Synthesis by TGF-β

1989 • 116 citations

The Transcription Factor EGR-1 Suppresses Transformation of Human Fibrosarcoma HT1080 Cells by Coordinated Induction of Transforming Growth Factor-β1, Fibronectin, and Plasminogen Activator Inhibitor-1

1999 • 111 citations

Impact of urokinase-type plasminogen activator and its inhibitor type 1 on prognosis in cervical cancer of the uterus.

1994 • 107 citations

Expression of growth factors and receptors during specific phases in regenerating urothelium after acute injury in vivo.

1994 • 106 citations

Structural alterations of transforming growth factor-? receptor genes in human cervical carcinoma

1999 • 100 citations

Evaluation of the risk of cervical intraepithelial neoplasia and human papilloma virus infection in renal transplant patients receiving immunosuppressive therapy.

1999 • 89 citations

Serum Levels of Transforming Growth Factor β1 in Patients With Breast Cancer

2001 • 88 citations

Differential response of nontumorigenic and tumorigenic human papillomavirus type 16-positive epithelial cells to transforming growth factor beta 1.

1990 • 87 citations

CYTOKINES IN CERVICOVAGINAL WASHING FLUID FROM PATIENTS WITH CERVICAL NEOPLASIA

2001 • 78 citations

Cytokine Profile of Cervical Cancer Cells

2001 • 78 citations

Immunology of the human papilloma virus in relation to cancer

1994 • 77 citations

Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns.

1997 • 68 citations

Transforming growth factor-β1 induces tumor stroma and reduces tumor infiltrate in cervical cancer

2002 • 67 citations

Quality control of immunohistochemical evaluation of tumour-associated plasminogen activators and related components

1998 • 66 citations

Transforming growth factor beta inhibits plasminogen activator (PA) activity and stimulates production of urokinase‐type PA, PA inhibitor‐1 mRNA, and protein in rat osteoblast‐like cells

1991 • 64 citations

Review

1995 • 62 citations

Altered expression of transforming growth factor-beta 1 in cervical neoplasia as an early biomarker in carcinogenesis of the uterine cervix.

1996 • 54 citations

Expression of transforming growth factor-beta 1 in human bladder cancer

1995 • 47 citations

Tumour-proliferative fraction and growth factor expression as markers of tumour response to radiotherapy in cancer of the uterine cervix

1998 • 46 citations

High tumor tissue concentration of plasminogen activator inhibitor 2 (PAI‐2) is an independent marker for shorter progression‐free survival in patients with early stage endometrial cancer

2001 • 44 citations

Genetic integrity of transforming growth factor β (TGF-β) receptors in cervical carcinoma cell lines: loss of growth sensitivity but conserved transcriptional response to TGF-β

1998 • 44 citations

Upregulation of PAI-1 is mediated through TGF-β/Smad pathway in transplant arteriopathy

2002 • 44 citations

Altered expression of transforming growth factor-β1 in cervical neoplasia as an early biomarker in carcinogenesis of the uterine cervix

1996 • 43 citations

Aberrant expression of Smad4 results in resistance against the growth‐inhibitory effect of transforming growth factor‐β in the SiHa human cervical carcinoma cell line

2001 • 38 citations

Transforming growth factor ?1, urokinase-type plasminogen activator and plasminogen activator inhibitor-1 mRNA expression in head and neck squamous carcinoma and normal adjacent mucosa

2001 • 37 citations

Decreased expression of retinoic acid receptors, transforming growth factor beta, involucrin, and cornifin in cervical intraepithelial neoplasia.

1999 • 36 citations

Decreased synthesis and expression of TGF-?1, ?2, and ?3 in epithelium of HPV 16-positive cervical precancer: a study by microdissection, quantitative RT-PCR, and immunocytochemistry

2000 • 34 citations

Urokinase-type plasminogen activator and plasminogen activator inhibitors (PAI-1 and PAI-2) in extracts of invasive cervical carcinoma and precursor lesions

1998 • 33 citations

Urokinase gene expression indicates early invasive growth in squamous cell lesions of the uterine cervix

1999 • 32 citations

Frequent aberration of the transforming growth factor-? receptor II gene in cell lines but no apparent mutation in pre-invasive and invasive carcinomas of the uterine cervix

1999 • 30 citations

Differential Response of Cervical Intraepithelial and Cervical Carcinoma Cell Lines to Transforming Growth Factor-β1

1994 • 29 citations

Interaction of specifically chemically modified dextrans with transforming growth factor β1: potentiation of its biological activity

2002 • 28 citations

Plasminogen activator inhibitors in endometrial adenocarcinoma

1993 • 27 citations

Pretreatment plasma TGFβ1 levels are prognostic for survival but not morbidity following radiation therapy of carcinoma of the cervix

2000 • 27 citations

The Concentration of Serum Transforming Growth Factor Beta-1 (TGF-β1) Is Decreased in Cervical Carcinoma Patients

2002 • 26 citations

Differential Transforming Growth Factor-β Secretion in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

1997 • 25 citations

Concentration of vascular endothelial growth factor (VEGF) and transforming growth factor-beta1 (TGF-beta1) in the serum of patients with cervical cancer: prediction of response

2000 • 23 citations

Tumor-Associated Proteolytic Factors uPA and PAI-1 in Endometrial Carcinoma

1997 • 22 citations

Plasminogen activator inhibitors in endometrial adenocarcinoma

1993 • 20 citations

Endocervical Cancer Is Associated with an Increase in the Ligands and Receptors for Transforming Growth Factor-β and a Contrasting Decrease in p27Kip1

2000 • 18 citations

Clinical relevance of urokinase‐type plasminogen activator and its inhibitor type 1 (PAI‐1) in squamous cell carcinoma of the uterine cervix

2002 • 15 citations

Differential cell cycle response of nontumorigenic and tumorigenic human papillomavirus-positive keratinocytes towards transforming growth factor-β1

2000 • 11 citations

Deleted Work

1955 • 0 citations

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