Expression of Epidermal Growth Factor Receptor (EGFR) and Activated EGFR Predict Poor Response to (Chemo)radiation and Survival in Cervical Cancer

Untangling the ErbB signalling network

2001 • 6,623 citations

Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck

2006 • 4,800 citations

An Immunohistochemical Study

1989 • 1,928 citations

Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.

2002 • 1,173 citations

Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors That Do Not Express the Epidermal Growth Factor Receptor by Immunohistochemistry

2005 • 1,081 citations

Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis

2001 • 1,063 citations

The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway

2004 • 889 citations

Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer

2008 • 735 citations

KRASMutation Is an Important Predictor of Resistance to Therapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancer

2007 • 597 citations

Stress and Radiation-Induced Activation of Multiple Intracellular Signaling Pathways¹

2003 • 460 citations

PTEN, more than the AKT pathway

2007 • 389 citations

Trafficking of the ErbB receptors and its influence on signaling

2003 • 344 citations

The epidermal growth factor receptor mediates radioresistance

2003 • 296 citations

Increased EGFR Gene Copy Number Detected by Fluorescent In Situ Hybridization Predicts Outcome in Non–Small-Cell Lung Cancer Patients Treated With Cetuximab and Chemotherapy

2008 • 279 citations

Quantitative Determination of Nuclear and Cytoplasmic Epidermal Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer by Using Automated Quantitative Analysis

2005 • 261 citations

Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis.

1999 • 245 citations

Blockage of Epidermal Growth Factor Receptor-Phosphatidylinositol 3-Kinase-AKT Signaling Increases Radiosensitivity of K-RAS Mutated Human Tumor Cells In vitro by Affecting DNA Repair

2006 • 207 citations

Radiation-induced EGFR-signaling and control of DNA-damage repair

2007 • 199 citations

Epidermal growth factor receptor and tumor response to radiation: in vivo preclinical studies

2004 • 159 citations

Molecular analysis of the PI3K‐AKT pathway in uterine cervical neoplasia: Frequent PIK3CA amplification and AKT phosphorylation

2005 • 152 citations

A phase II trial to evaluate gefitinib as second- or third-line treatment in patients with recurring locoregionally advanced or metastatic cervical cancer

2007 • 136 citations

Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) negatively affect overall survival in carcinoma of the cervix treated with radiotherapy

2003 • 127 citations

Increased expression of pAKT is associated with radiation resistance in cervical cancer

2006 • 120 citations

Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer

2006 • 117 citations

Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma: An immunohistochemical study

1996 • 96 citations

Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix

2005 • 94 citations

Epigenetic and genetic alternation of PTEN in cervical neoplasm

2004 • 94 citations

The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer

2008 • 86 citations

Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma

2007 • 66 citations

Consistent absence of BRAF mutations in cervical and endometrial cancer despite KRAS mutation status

2005 • 65 citations

Mutation of the PTEN gene in advanced cervical cancer correlated with tumor progression and poor outcome after radiotherapy

2001 • 60 citations

Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy

2006 • 56 citations

The prognostic significance of human epidermal growth factor receptor correlations in squamous cell cervical carcinoma.

2007 • 52 citations

P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma

2003 • 40 citations

Correlation Among Six Biologic Factors (p53, p21WAF1, MIB-1, EGFR, HER2, and Bcl-2) and Clinical Outcomes After Curative Chemoradiation Therapy in Squamous Cell Cervical Cancer

2008 • 36 citations

Absence of epidermal growth factor receptor mutations in cervical cancer

2007 • 36 citations

Gynecologic examination and cervical biopsies after (chemo) radiation for cervical cancer to identify patients eligible for salvage surgery

2006 • 31 citations

Expression of PTEN in the progression of cervical neoplasia and its relation to tumor behavior and angiogenesis in invasive squamous cell carcinoma

2006 • 31 citations

Epidermal growth factor receptor-targeted therapy

2008 • 27 citations

Cyclooxygenase-2 and Epidermal Growth Factor Receptor Expressions in Different Histological Subtypes of Cervical Carcinomas

2007 • 25 citations

Analysis of chromosomes 3, 7, X and the EGFR gene in uterine cervical cancer progression

2004 • 24 citations

Absence of point mutation in codons 12 and 13 of K-RAS oncogene in HPV-associated high grade dysplasia and squamous cell cervical carcinoma

2003 • 22 citations

Evaluation of PTEN expression in cervical adenocarcinoma by tissue microarray

2006 • 20 citations

“Low-risk” and “High-risk” HPV-infection and K-ras Gene Point Mutations in Human Cervical Cancer

2001 • 15 citations

Evaluation ofPTENexpression in cervical adenocarcinoma by tissue microarray

2006 • 7 citations