Insulin-Specific Tolerance in Diabetes

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

QUANTITATIVE ASPECTS OF THE REACTION BETWEEN INSULIN AND INSULIN-BINDING ANTIBODY

1959 • 612 citations

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

1991 • 562 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).

1996 • 415 citations

Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes

2001 • 386 citations

Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes

1996 • 315 citations

Insulin prophylaxis in individuals at high risk of type 1 diabetes

1993 • 303 citations

Insulitis and Diabetes in NOD Mice Reduced by Prophylactic Insulin Therapy

1990 • 296 citations

Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice

1994 • 279 citations

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

1992 • 275 citations

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

1995 • 248 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes

1999 • 223 citations

No effect of oral insulin on residual beta-cell function in recent-onset Type I diabetes (the IMDIAB VII)

2000 • 211 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals

1985 • 208 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Self-antigen–presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

2001 • 171 citations

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4

1999 • 159 citations

Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice.

1996 • 154 citations

Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the Fourth International Workshop on the Standardization of Insulin Autoantibody Measurement.

1992 • 147 citations

Autoreactive T cell Responses in Insulin-dependent (Type 1) Diabetes Mellitus. Report of the First International Workshop for Standardization of T cell assays

1999 • 130 citations

Immunologic Reactions to Insulin: Insulin Allergy, Insulin Resistance, and the Autoimmune Insulin Syndrome

1979 • 124 citations

DNA immunization to prevent autoimmune diabetes

1999 • 123 citations

International Workshop on Lessons From Animal Models for Human Type 1 Diabetes

2001 • 117 citations

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

1998 • 116 citations

Ir-gene control of immunogenicity of insulin and A-chain loop as a carrier determinant

1975 • 112 citations

Insulin autoimmune syndrome (IAS, Hirata disease).

1999 • 106 citations

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.

1995 • 103 citations

Spontaneous Hypoglycemia with Insulin Autoimmunity in Graves' Disease

1974 • 100 citations

T cell autoreactivity to insulin in diabetic and related non-diabetic individuals.

1988 • 100 citations

Plasmid Vaccination with Insulin B Chain Prevents Autoimmune Diabetes in Nonobese Diabetic Mice

2001 • 97 citations

Regulatory Th2-type T cell Lines Against Insulin and GAD Peptides Derived from Orally- and Nasally-Treated NOD Mice Suppress Diabetes

1999 • 94 citations

Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

1995 • 86 citations

Diabetes Mellitus in Rabbits Immunized with Insulin

1966 • 79 citations

Insulin in Oral Immune “Tolerance”: A One-Amino Acid Change in the B Chain Makes the Difference

1999 • 78 citations

Changes in the Islets of Langerhans in Cows Injected with Heterologous and Homologous Insulin

1966 • 78 citations

Autoimmune disease models : a guidebook

1994 • 77 citations

T cell Autoreactivity to Proinsulin Epitopes in Diabetic Patients and Healthy Subjects

1999 • 76 citations

The Role of CD4 . CD8 T Cells in IDDM

1999 • 75 citations

Anergy and not Clonal Ignorance Determines the Fate of B Cells that Recognize a Physiological Autoantigen

2001 • 75 citations

T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

2000 • 74 citations

Characterization of Insulin Autoantibodies in Relatives of Patients With Type I Diabetes

1993 • 74 citations

Peptide and Major Histocompatibility Complex–Specific Breaking of Humoral Tolerance to Native Insulin With the B9-23 Peptide in Diabetes-Prone and Normal Mice

2001 • 69 citations

Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats

1991 • 67 citations

Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse

1997 • 66 citations

Update on Major Trials for the Prevention of Type I Diabetes Mellitus: The American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT)

2001 • 57 citations

Immunization with DNA Encoding an Immunodominant Peptide of Insulin Prevents Diabetes in NOD Mice

2001 • 55 citations

T-cell response to proinsulin and insulin in type 1 and pretype 1 diabetes.

1999 • 39 citations

The histopathology of immune diabetes in the rabbit.

1968 • 31 citations

Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.

1995 • 31 citations

Antigen‐specific immunotherapy: Oral tolerance and subcutaneous immunization in the treatment of insulin‐dependent diabetes

1993 • 30 citations

An insulin peptide that binds an alternative site in class II major histocompatibility complex.

1996 • 26 citations

Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common environmental cross-reactivity in the pathogenicity of type 1 diabetes.

1999 • 21 citations

Cellular immune response to phogrin in the NOD mouse: cloned T-cells cause destruction of islet transplants.

1999 • 21 citations

Multiple Genes/Multiple Autoantigens Role in Type 1 Diabetes

2000 • 19 citations

T-cell mediated autoimmunity to the insulinoma-associated protein 2 islet tyrosine phosphatase in type 1 diabetes mellitus

1999 • 16 citations

Etiology and Pathogenesis of Human Insulin-Dependent Diabetes Mellitus

1999 • 7 citations

The BB Rat Models of IDDM

1994 • 7 citations

When the patient is resistant or allergic to insulin.

1980 • 7 citations