Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

1994 • 429 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Insulin prophylaxis in individuals at high risk of type 1 diabetes

1993 • 303 citations

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.

1994 • 300 citations

Insulitis and Diabetes in NOD Mice Reduced by Prophylactic Insulin Therapy

1990 • 296 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

1989 • 284 citations

Prevention of Type I Diabetes in NOD Mice by Adjuvant Immunotherapy

1990 • 264 citations

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice.

1989 • 257 citations

Insulitis in type 1 (insulin‐dependent) diabetes mellitus in man—macrophages, lymphocytes, and interferon‐γ containing cells

1991 • 236 citations

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans.

1988 • 235 citations

Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals

1985 • 208 citations

Peptide therapy for diabetes in NOD mice

1994 • 205 citations

Immunostimulation circumvents diabetes in NODLt mice

1989 • 182 citations

CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta.

1991 • 175 citations

Cytotoxic Effects of Cytokines on Human Pancreatic Islet Cells in Monolayer Culture*

1990 • 174 citations

CD4 monoclonal antibody pairs for immunosuppression and tolerance induction

1987 • 173 citations

Effect of adjuvant therapy on development of diabetes in mouse and man

1994 • 157 citations

Altered Cytokine Activity in Adjuvant Inhibition of Autoimmune Diabetes

1993 • 151 citations

A miniaturized mouse mixed leukocyte culture in serum-free and mouse serum supplemented media

1973 • 150 citations

Islet cell autoantigens in insulin-dependent diabetes.

1993 • 136 citations

Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy

1990 • 97 citations

Dependence of Antigen Expression on Functional State of β-Cells

1990 • 92 citations

Prevention of type I diabetes in NOD mice by adjuvant immunotherapy

1990 • 76 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1994 • 75 citations

Insulin-Dependent Diabetes in the Nod Mouse Model II. β Cell Destruction in Autoimmune Diabetes is a T_H2and not A T_H1Mediated Event

1993 • 70 citations

Resistance to experimental autoimmune thyroiditis: L3T4+ cells as mediators of both thyroglobulin-activated and TSH-induced suppression

1989 • 69 citations

Prevention of Diabetes in NOD Mice by Injection of Autoreactive T-Lymphocytes

1989 • 60 citations

Islet‐infiltrating T cell clones from non‐obese diabetic mice that promote or prevent accelerated onset diabetes

1991 • 49 citations

New perspectives on immunointervention in autoimmune diseases

1990 • 49 citations

Prevention of autoimmune type I diabetes by CD4+ suppressor T cells in superantigen-treated non-obese diabetic mice.

1993 • 39 citations

Antigen‐specific immunotherapy: Oral tolerance and subcutaneous immunization in the treatment of insulin‐dependent diabetes

1993 • 30 citations

Prevention of diabetes in NOD mice by injection of autoreactive T-lymphocytes

1989 • 26 citations

Dependence of antigen expression on functional state of beta-cells

1990 • 22 citations

Modulation of Beta-Cell Activity and its Influence on Islet Cell Antibody (ICA) and Islet Cell Surface Antibody (ICSA) Reactivity

1993 • 18 citations

Development of antigen-specific therapies for autoimmune disease.

1990 • 2 citations