Autoreactive T cell Responses in Insulin-dependent (Type 1) Diabetes Mellitus. Report of the First International Workshop for Standardization of T cell assays

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

The Pathogenesis of Insulin-Dependent Diabetes Mellitus

1994 • 1,077 citations

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

1985 • 935 citations

Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients.

1993 • 599 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

1994 • 452 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

Combined Analysis of Autoantibodies Improves Prediction of IDDM in Islet Cell Antibody-Positive Relatives

1994 • 360 citations

Factors Associated with Early Remission of Type I Diabetes in Children Treated with Cyclosporine

1988 • 330 citations

Susceptibility to type I diabetes: HLA-DQ and DR revisited

1996 • 324 citations

SYNOVIAL FLUID T CELL REACTIVITY AGAINST 65 kD HEAT SHOCK PROTEIN OF MYCOBACTERIA IN EARLY CHRONIC ARTHRITIS

1988 • 311 citations

Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology

1994 • 311 citations

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

1992 • 275 citations

Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).

1995 • 257 citations

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1993 • 247 citations

Insulitis in type 1 (insulin‐dependent) diabetes mellitus in man—macrophages, lymphocytes, and interferon‐γ containing cells

1991 • 236 citations

Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.

1993 • 236 citations

Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation

1993 • 211 citations

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile.

1994 • 211 citations

Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.

1999 • 183 citations

T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins

1990 • 179 citations

T-Cell Responses to Autoantigens in IDDM: The Search for the Holy Grail

1996 • 164 citations

T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.

1994 • 162 citations

Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipient characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft

1998 • 156 citations

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.

1997 • 148 citations

Early signaling defects in human T cells anergized by T cell presentation of autoantigen.

1992 • 143 citations

Increase in Remission Rate in Newly Diagnosed Type I Diabetic Subjects Treated with Azathioprine

1985 • 138 citations

Cell-mediated immune response to β casein in recent-onset insulin-dependent diabetes: implications for disease pathogenesis

1996 • 134 citations

Can We Really Predict IDDM?

1993 • 129 citations

Cellular Immune Response to Diverse Islet Cell Antigens in IDDM

1996 • 123 citations

Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4

1994 • 110 citations

T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes

1991 • 110 citations

Genetic Structure of IDDM1: Two Separate Regions in the Major Histocompatibility Complex Contribute to Susceptibility or Protection

1998 • 88 citations

Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry

1998 • 86 citations

Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient.

1996 • 85 citations

T-Cell Reactivity to β-Cell Membrane Antigens Associated With β-Cell Destruction in IDDM

1995 • 83 citations

T Lymphocyte Subsets, Cytokines, and Effector Functions

1992 • 82 citations

Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects

1997 • 78 citations

T Cells from the Peripheral Blood of Coeliac Disease Patients Recognize Gluten Antigens when Presented by HLA‐DR, ‐DQ, or ‐DP Molecules

1994 • 69 citations

Cytokine overproduction in healthy first degree relatives of patients with IDDM

1998 • 67 citations

HLA‐associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent‐onset insulin‐dependent diabetes mellitus

1996 • 66 citations

Abnormal T-Lymphocyte Subsets in Type I Diabetes

1989 • 65 citations

The relationship between humoral and cellular immunity to IA-2 in IDDM.

1998 • 56 citations

High Affinity Presentation of an Autoantigenic Peptide in Type I Diabetes by an HLA Class II Protein Encoded in a Haplotype Protecting From Disease

1997 • 55 citations

Increased Numbers ofin vivoActivated T cells in Patients with Recent Onset Insulin-dependent Diabetes Mellitus

1996 • 53 citations

T cell activation and anergy to islet cell antigen in type I diabetes.

1995 • 51 citations

GAD65-Reactive T cells in a Non-diabetic Stiff-man Syndrome Patient

1999 • 51 citations

Increase in Simultaneous Coexpression of Naive and Memory Lymphocyte Markers at Diagnosis of IDDM

1993 • 45 citations

Autoreactive and immunoregulatory T-cell subsets in insulindependent diabetes mellitus

1999 • 43 citations

Persistent reduction of CD4/CD8 lymphocyte ratio amd cell activation before the onset of Type 1 (insulin-dependent) diabetes

1989 • 32 citations

Cellular immune responses to β casein: elevated in but not specific for individuals with Type I diabetes mellitus

1998 • 29 citations

Th1-like Cytokine Production Profile and Individual Specific Alterations in TCRBV-gene Usage of T Cells from Newly Diagnosed Type 1 Diabetes Patients after Stimulation with β-cell Antigens

1997 • 23 citations

T Cell Proliferative Responses to Glutamic Acid Decarboxylase-65 in IDDM are Negatively Associated with HLA DR3/4

1995 • 20 citations

Activated CD4+ and CD8+ T‐lymphocytes in Newly Diagnosed Type 1 Diabetes: a Prospective Study

1990 • 12 citations

Analysis of peripheral blood mononuclear cells in rodents by three-colour flow cytometry using a small-volume lysed whole blood technique

1993 • 12 citations

Definition of antigenic determinants on glutamic acid decarboxylase molecule in HLA-DQ transgenic mice

1996 • 2 citations

Studies on the HLA association to insulin-dependent diabetes mellitus (IDDM).

1988 • 1 citations