Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

A sequence pattern common to T cell epitopes.

1988 • 623 citations

T-cell antigenic sites tend to be amphipathic structures.

1985 • 527 citations

The structure and evolution of the two nonallelic rat preproinsulin genes

1979 • 500 citations

The Murine Autoimmune Diabetes Model: NOD and Related Strains

1992 • 498 citations

Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.

1980 • 496 citations

Prediction of immunodominant helper T cell antigenic sites from the primary sequence.

1987 • 483 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes

1988 • 351 citations

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

1987 • 319 citations

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

1989 • 310 citations

Interactions between Immunogenic Peptides and MHC Proteins

1991 • 303 citations

The genetic susceptibility to type 1 (insulin-dependent) diabetes: Analysis of the HLA-DR association

1983 • 251 citations

Insulitis in type 1 (insulin‐dependent) diabetes mellitus in man—macrophages, lymphocytes, and interferon‐γ containing cells

1991 • 236 citations

Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.

1993 • 236 citations

HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitus

1981 • 231 citations

Isolation and characterization of a cloned rat insulin gene

1979 • 229 citations

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile.

1994 • 211 citations

64 000 Mr autoantibodies as predictors of insulin-dependent diabetes

1990 • 208 citations

The insulin secretory granule

1989 • 188 citations

T-Lymphocyte Clone Specific for Pancreatic Islet Antigen

1988 • 188 citations

Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats

1989 • 183 citations

Structural model of HLA-DR1 restricted T cell antigen recognition

1988 • 172 citations

Differential Expression of GAD65 and GAD67 in Human, Rat, and Mouse Pancreatic Islets

1993 • 165 citations

Identification and Cloning of a Granule Autoantigen (Carboxypeptidase-H) Associated with Type I Diabetes*

1991 • 160 citations

Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice.

1994 • 157 citations

Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.

1981 • 155 citations

Analysis of the roles of CD4⁺ and CD8⁺ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice

1992 • 145 citations

Prevention of Autoimmune Diabetes in the BB Rat by Intrathymic Islet Transplantation at Birth

1992 • 141 citations

Islet cell autoantigens in insulin-dependent diabetes.

1993 • 136 citations

Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes.

1993 • 113 citations

Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic Beta cell

1991 • 112 citations

Islet-Specific T-Cell Clones From the NOD Mouse Respond to β-Granule Antigen

1994 • 99 citations

T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats.

1989 • 98 citations

Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.

1991 • 96 citations

The Onset and Progression of Pancreatic Insulitis in the Overt, Spontaneously Diabetic, Young Adult BB Rat Studied by Pancreatic Biopsy

1984 • 95 citations

Characterization of a cDNA coding for rat glutamic acid decarboxylase

1990 • 80 citations

Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of Type 1 (insulin-dependent) diabetic patients

1988 • 80 citations

Dynamic time course studies of the spontaneously diabetic BB Wistar rat. III. Light-microscopic and ultrastructural observations of pancreatic islets of Langerhans.

1982 • 76 citations

Spontaneous diabetes mellitus syndrome in the rat. II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration.

1983 • 76 citations

Presentation of beta-cell antigens to CD4+ and CD8+ T cells of non-obese diabetic mice.

1993 • 75 citations

Revelation of Specificity of 64K Autoantibodies in IDDM Serums by High-Resolution 2-D Gel Electrophoresis: Unambiguous Identification of 64K Target Antigen

1989 • 66 citations

Structural requirements for the interaction between peptide antigens and I-Ed molecules.

1989 • 65 citations

Identification of myocarditogenic peptides derived from cardiac myosin capable of inducing experimental allergic myocarditis in the Lewis rat. The utility of a class II binding motif in selecting self-reactive peptides.

1994 • 65 citations

Isolation of Nonobese Diabetic Mouse T-Cells That Recognize Novel Autoantigens Involved in the Early Events of Diabetes

1994 • 46 citations

Kinetics of Proinsulin Conversion in Human Islets

1993 • 39 citations

IDDM in BB Rats: Enhanced MHC Class I Heavy-Chain Gene Expression in Pancreatic Islets

1988 • 37 citations

Secretory granule autoantigen in insulin-dependent diabetes mellitus is related to 62 kDa heat-shock protein (hsp60)

1992 • 35 citations

Immunologic and genetic studies of diabetes in the BB rat.

1989 • 34 citations

CD8+ T-cells are Required for Adoptive Transfer of the BB Rat Diabetic Syndrome

1993 • 33 citations

Identification of an N-terminally acetylated encephalitogenic epitope in myelin proteolipid apoprotein for the Lewis rat.

1994 • 33 citations

The Pathogenesis, Prediction, and Prevention of Insulin-Dependent Diabetes Mellitus

1992 • 32 citations

Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II

1991 • 31 citations

Involvement of dendritic cells in early insulitis of BB rats

1992 • 30 citations

1 Overview: the major histocompatibility complex and insulin dependent diabetes mellitus

1991 • 28 citations

Potential Autoantigens In IDDM: Expression of Carboxypeptidase-H and Insulin But Not Glutamate Decarboxylase on the β-Cell Surface

1994 • 27 citations

T-cell autoimmunity in type 1 diabetes mellitus

1993 • 24 citations

Genetic susceptibility to the development of spontaneous insulin-dependent diabetes mellitus in the rat

1990 • 21 citations

The pathogenesis of autoimmune diabetes mellitus

1990 • 19 citations

A single dose of the MHC-linked susceptibility determinant associated with the RT1u haplotype is permissive for insulin-dependent diabetes mellitus in the BB rat.

1990 • 14 citations

Different Lymphocyte Subset Distribution within “Insulitis” Islets of Normoglycaemic and Prediabetic BB/OK Rats of Similar Age^*)

2009 • 6 citations

Recognition of the HLA class II-peptide complex by T-cell receptor: reversal of major histocompatibility complex restriction of a T-cell clone by a point mutation in the peptide determinant

1989 • 4 citations

The R1-rat: a new RT1 haplotype.

1979 • 4 citations

The T-Cell Repertoire Contains Cells Reactive with Hormones of the Hypothalamic-Pituitary-Adrenal Axis: Recognition of Synthetic Peptide Fragments of Corticotropin-Releasing Hormone (CRH) and Proopiomelanocortin (POMC) in the Lewis Rat

1994 • 3 citations