Plasmid Vaccination with Insulin B Chain Prevents Autoimmune Diabetes in Nonobese Diabetic Mice

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

1996 • 1,498 citations

Insulin-Dependent Diabetes Mellitus

1996 • 1,171 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

Structure of a human insulin peptide–HLA-DQ8 complex and susceptibility to type 1 diabetes

2001 • 386 citations

Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a Th2‐biased pattern which persists after adult boosting

1996 • 278 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

1993 • 254 citations

Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells

1999 • 248 citations

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice

1997 • 223 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

2001 • 210 citations

Differential ability of T cell subsets to undergo activation-induced cell death

1997 • 188 citations

Autoreactive CD4+ T Cells Protect from Autoimmune Diabetes via Bystander Suppression Using the IL-4/Stat6 Pathway

1999 • 184 citations

Induction of Glutamic Acid Decarboxylase 65-Specific Th2 Cells and Suppression of Autoimmune Diabetes at Late Stages of Disease Is Epitope Dependent

1999 • 173 citations

Th1 to Th2 Cytokine Shifts in Nonobese Diabetic Mice: Sometimes an Outcome, Rather Than the Cause, of Diabetes Resistance Elicited by Immunostimulation

2001 • 172 citations

DNA immunization to prevent autoimmune diabetes

1999 • 123 citations

Cytokines that regulate autoimmune responses

1999 • 118 citations

Antigen-Specific Mediated Suppression of β Cell Autoimmunity by Plasmid DNA Vaccination

2001 • 111 citations

Suppressive Immunization with DNA Encoding a Self-Peptide Prevents Autoimmune Disease: Modulation of T Cell Costimulation

1999 • 106 citations

Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses

2001 • 88 citations

Interleukin-4 Deficiency Does Not Exacerbate Disease in NOD Mice

1998 • 87 citations

gd T cells as mediators of mucosal tolerance: the autoimmune diabetes model

2000 • 85 citations

Induction of humoral and cellular immunity against influenza virus by immunization of newborn mice with a plasmid bearing a hemagglutinin gene

1997 • 75 citations

Infectious Th1 and Th2 autoimmunity in diabetes‐prone mice

1998 • 65 citations

CD4+ beta islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice.

1995 • 57 citations

Presence of CpG DNA and the Local Cytokine Milieu Determine the Efficacy of Suppressive DNA Vaccination in Experimental Autoimmune Encephalomyelitis

1999 • 47 citations

Local IL-4 Expression in the Lung Reduces Pulmonary Influenza-Virus-Specific Secondary Cytotoxic T Cell Responses

2000 • 42 citations

Demonstration of a TH1cytokine profile in the late phase of NOD insulitis

1995 • 39 citations

Protective DNA vaccination against organ-specific autoimmunity is highly specific and discriminates between single amino acid substitutions in the peptide autoantigen

2000 • 38 citations

Prevention of neonatal tolerance by a plasmid encoding granulocyte-macrophage colony stimulating factor

1999 • 31 citations

Protection from autoimmune diabetes by adjuvant therapy non-obese diabetic mouse: The role of interleukin-4 and interleukin-10

1997 • 31 citations

Protective Cellular Immunity Against Influenza VirusInduced by Plasmid Inoculation of Newborn Mice

1997 • 26 citations

Bystander suppression induced by oral tolerance

1997 • 18 citations

Interleukin-4-deficient mice

1993 • 16 citations