Caspase 3-Mediated Inactivation of Rac GTPases Promotes Drug-Induced Apoptosis in Human Lymphoma Cells

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Caspases: killer proteases

1997 • 2,440 citations

Role of Poly(ADP-ribose) Polymerase (PARP) Cleavage in Apoptosis

1999 • 836 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

2000 • 404 citations

p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis

2000 • 356 citations

Rho signals to cell growth and apoptosis

2001 • 312 citations

Rho GTPases in transformation and metastasis

2002 • 274 citations

Rho Family Proteins Modulate Rapid Apoptosis Induced by Cytotoxic T Lymphocytes and Fas

2000 • 244 citations

Rho GTPase signalling pathways in the morphological changes associated with apoptosis

2002 • 239 citations

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

2000 • 238 citations

Rac1 inhibits TNF‐α‐induced endothelial cell apoptosis: dual regulation by reactive oxygen species

2000 • 230 citations

D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis

1996 • 216 citations

Activation of Rac GTPase by p75 Is Necessary for c-junN-Terminal Kinase-Mediated Apoptosis

2002 • 203 citations

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

1997 • 192 citations

Suppression of Ras-Induced Apoptosis by the Rac GTPase

1999 • 177 citations

Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB

2002 • 154 citations

Proteolytic activation of PKN by caspase-3 or related protease during apoptosis

1998 • 129 citations

Activation of the RacGTPase inhibits apoptosis in human tumor cells

2001 • 123 citations

Caspase-mediated Cleavage of DNA Topoisomerase I at Unconventional Sites during Apoptosis

1999 • 105 citations

Regulation of Cell Function by Rho Family GTPases

2000 • 100 citations

Characterization of the Interactions between the Small GTPase Cdc42 and Its GTPase-activating Proteins and Putative Effectors

1997 • 99 citations

Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway

1998 • 98 citations

Staurosporine analogues — pharmacological toys or useful antitumour agents?

2000 • 97 citations

Apoptosis and the response to anticancer therapy

2001 • 90 citations

Anti-apoptotic function of Rac in hematopoietic cells

1999 • 88 citations

Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis

1998 • 84 citations

Apoptosis Induced by Rac GTPase Correlates with Induction of FasL and Ceramides Production

2000 • 78 citations

Cdc42 Is a Substrate for Caspases and Influences Fas-induced Apoptosis

2001 • 72 citations

Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase

1997 • 71 citations

Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-GDI, during apoptosis

1999 • 67 citations

Interaction of Rac1 with GTPase-activating Proteins and Putative Effectors

1998 • 65 citations

Rho-dependent cell spreading activated by E.coli cytotoxic necrotizing factor 1 hinders apoptosis in epithelial cells

1998 • 65 citations

Differential Effect of Rac and Cdc42 on p38 Kinase Activity and Cell Cycle Progression of Nonadherent Primary Mouse Fibroblasts

2000 • 63 citations

Bcl-2 Does Not Protect Burkitt's Lymphoma Cells From Oxidant-Induced Cell Death

1997 • 60 citations

Induction of Apoptosis by Chemotherapeutic Drugs without Generation of Reactive Oxygen Species

2002 • 59 citations

Apoptotic Cleavage of Scaffold Attachment Factor A (SAF-A) by Caspase-3 Occurs at a Noncanonical Cleavage Site

2000 • 53 citations

Oligomerization of Rac1 GTPase Mediated by the Carboxyl-terminal Polybasic Domain

2001 • 52 citations

The Small GTPase Rac Suppresses Apoptosis Caused by Serum Deprivation in Fibroblasts

2001 • 35 citations

Participation of small GTPases Rac1 and Cdc42Hs in myoblast transformation

2002 • 31 citations

Ras and Rac as Activators of Reactive Oxygen Species (ROS)

2003 • 29 citations

Rac1 prevents cisplatin‐induced apoptosis through down‐regulation of p38 activation in NIH3T3 cells

2002 • 29 citations

Rac-dependent Anti-apoptotic Signaling by the Insulin Receptor Cytoplasmic Domain

1999 • 28 citations

Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis.

2001 • 25 citations

Caspase‐3 mediated cleavage of HsRad51 at an unconventional site

2000 • 12 citations