Rho GTPases are over-expressed in human tumors

p53 Mutations in Human Cancers

1991 • 8,133 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Hyperexpression of mitogen-activated protein kinase in human breast cancer.

1997 • 454 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

Botulinum ADP‐ribosyltransferase C3

1988 • 162 citations

Rho proteins induce metastatic properties in vivo

1997 • 160 citations

The Ras-related Small GTP-binding Protein RhoB Is Immediate-early Inducible by DNA Damaging Treatments

1995 • 149 citations

myc oncogenes: activation and amplification

1987 • 147 citations

Nucleotide sequence of human rho cDNA clone 12

1987 • 143 citations

Coding sequence of humanrhocDNAs clone 6 and clone 9

1988 • 137 citations

RhoGDI-3 Is a New GDP Dissociation Inhibitor (GDI)

1996 • 117 citations

Characterization and expression of the human rhoH12 gene product.

1989 • 108 citations

Copurification of rho protein and the rho-GDP dissociation inhibitor from bovine neutrophil cytosol. Effect of phosphoinositides on rho ADP-ribosylation by the C3 exoenzyme of Clostridium botulinum

1992 • 61 citations

Activity of the DNA repair protein O6-methylguanine-DNA methyltransferase in human tumor and corresponding normal tissue.

1996 • 56 citations

Actin filament organization of the Dunning R3327 rat prostatic adenocarcinoma system: correlation with metastatic potential.

1986 • 31 citations

Activator Protein Supporting the Botulinum ADP-ribosyltransferase Reaction

1989 • 23 citations

ADP-ribosylation of Rho proteins by Clostridium botulinum exoenzyme C3 is influenced by phosphorylation of Rho-associated factors

1994 • 20 citations

Cancer: Functions of ras oncogenes

1984 • 13 citations

Differentiation‐induced increase in Clostridium botulinum C3 exoenzyme‐catalyzed ADP‐ribosylation of the small GTP‐binding protein Rho

1994 • 12 citations