Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine

Probability-based protein identification by searching sequence databases using mass spectrometry data

1999 • 8,138 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cancer Cell Cycles

1996 • 5,379 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

1997 • 1,324 citations

Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

1997 • 680 citations

Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

1994 • 625 citations

Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators

2000 • 501 citations

Quantitation of microgram amounts of protein in two‐dimensional polyacrylamide gel electrophoresis sample buffer

1985 • 489 citations

Multivariate Statistical Methods: A Primer.

1987 • 394 citations

A nonlinear wide‐range immobilized pH gradient for two‐dimensional electrophoresis and its definition in a relevant pH scale

1993 • 386 citations

The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation*

1999 • 358 citations

Cyclins, Cyclin-Dependent Kinases and Cdk Inhibitors: Implications in Cell Cycle Control and Cancer

1995 • 314 citations

Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors: Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds

1997 • 241 citations

Human liver protein map: A reference database established by microsequencing and gel comparison

1992 • 129 citations

Crystal structure of recombinant human triosephosphate isomerase at 2.8 Å resolution. Triosephosphate isomerase‐related human genetic disorders and comparison with the trypanosomal enzyme

1994 • 116 citations

Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma

1999 • 109 citations

The role of p16-cyclin D/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma

2000 • 88 citations

Identification of Two Human Rho GDP Dissociation Inhibitor Proteins Whose Overexpression Leads to Disruption of the Actin Cytoskeleton

1993 • 86 citations

High prevalence of p16 genetic alterations in head and neck tumours

1999 • 81 citations

The p16-cyclin D1/CDK4-pRb pathway and clinical outcome in epithelial ovarian cancer.

1999 • 78 citations

Changes of the p16 gene but not the p53 gene in human chondrosarcoma tissues

2000 • 69 citations

Synthetic cyclin dependent kinase inhibitors. New generation of potent anti-cancer drugs.

1999 • 61 citations

Synthetic Cyclin Dependent Kinase Inhibitors

1999 • 54 citations

Cell-cycle dysregulation and the molecular mechanisms of prostate cancer

2000 • 53 citations

Expression of Tumor Suppressor Gene p16<sup>INK4</sup> Products in Primary Gastric Cancer

2000 • 47 citations

Induction of apoptosis and regression of spontaneous dog melanoma following in vivo application of synthetic cyclin-dependent kinase inhibitor olomoucine

1997 • 29 citations