RhoGDI Is Required for Cdc42-Mediated Cellular Transformation

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Rab GTPases: specifying and deciphering organelle identity and function

2001 • 525 citations

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI

2000 • 494 citations

IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs.

1996 • 387 citations

Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein

1999 • 319 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.

1990 • 277 citations

Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.

1990 • 268 citations

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

1997 • 252 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

The γ-subunit of the coatomer complex binds Cdc42 to mediate transformation

2000 • 211 citations

Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

1998 • 198 citations

Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

1991 • 195 citations

Specific Contributions of the Small GTPases Rho, Rac, and Cdc42 to Dbl Transformation

1999 • 177 citations

The identification and characterization of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein

1992 • 175 citations

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

2003 • 173 citations

Multiple roles for Cdc42 in cell regulation

2001 • 165 citations

A GDP Dissociation Inhibitor That Serves as a GTPase Inhibitor for the Ras-Like Protein CDC42Hs

1992 • 164 citations

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

1999 • 162 citations

Identification of an Actin Cytoskeletal Complex That Includes IQGAP and the Cdc42 GTPase

1997 • 141 citations

Characterization of the Interaction between RhoGDI and Cdc42Hs Using Fluorescence Spectroscopy

1996 • 129 citations

Multifunctional Roles for the PH Domain of Dbs in Regulating Rho GTPase Activation

2003 • 84 citations

Purification and characterization of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages.

1991 • 78 citations

Residues of the Rho Family GTPases Rho and Cdc42 That Specify Sensitivity to Dbl-like Guanine Nucleotide Exchange Factors

1997 • 68 citations

Kinetics of Cdc42 Membrane Extraction by Rho-GDI Monitored by Real-Time Fluorescence Resonance Energy Transfer

1999 • 63 citations

Iqg1p links spatial and secretion landmarks to polarity and cytokinesis

2002 • 56 citations

RhoGDI-binding-defective mutant of Cdc42Hs targets to membranes and activates filopodia formation but does not cycle with the cytosol of mammalian cells

2001 • 34 citations

RhoGDI-binding-defective mutant of Cdc42Hs targets to membranes and activates filopodia formation but does not cycle with the cytosol of mammalian cells

2001 • 29 citations