Study of Therapy Resistance in Cancer Cells with Functional Proteome Analysis

Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G‐250 and R‐250

1988 • 2,665 citations

Structure of TPR Domain–Peptide Complexes

2000 • 1,159 citations

Multidrug resistance (MDR) in cancer

2000 • 1,013 citations

Calreticulin: one protein, one gene, many functions

1999 • 726 citations

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases

1998 • 692 citations

Hyperthermia in oncology

2001 • 638 citations

Hsp90 & Co. – a holding for folding

1999 • 631 citations

Small Stress Proteins as Novel Regulators of Apoptosis

1996 • 614 citations

Heat shock proteins transfer peptides during antigen processing and CTL priming

1994 • 580 citations

Role and regulation of the ER chaperone BiP

1999 • 539 citations

Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins

2000 • 532 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

HSP27 inhibits cytochrome c‐dependent activation of procaspase‐9

1999 • 496 citations

Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.

1992 • 376 citations

Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody

1996 • 354 citations

Use of thiourea to increase the solubility of membrane proteins in two‐dimensional electrophoresis

1998 • 342 citations

Multidrug Resistance1

1988 • 321 citations

Structure and in vivo function of Hsp90

2000 • 317 citations

Multiple physiological functions for multidrug transporter P-glycoprotein?

2000 • 305 citations

Delayed Extraction Improves Specificity in Database Searches by Matrix-assisted Laser Desorption/Ionization Peptide Maps

1996 • 297 citations

Small stress proteins: chaperones that act as regulators of intracellular redox state and programmed cell death.

1998 • 283 citations

Calcium, a signaling molecule in the endoplasmic reticulum?

2000 • 262 citations

BiP (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum

1994 • 227 citations

Heat shock proteins – modulators of apoptosis in tumour cells

2000 • 216 citations

14-3-3 Proteins Associate with A20 in an Isoform-specific Manner and Function Both as Chaperone and Adapter Molecules

1996 • 181 citations

Functional analysis of the hsp90-associated human peptidyl prolyl Cis/Trans isomerases FKBP51, FKBP52 and cyp40 1 1Edited by R. Huber

2001 • 178 citations

Molecular Mechanisms of Multidrug Resistance in Cancer Chemotherapy

1996 • 169 citations

The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain.

1994 • 155 citations

Heat-resistant variants of Chinese hamster fibroblasts altered in expression of heat shock protein.

1985 • 151 citations

Phosphorylation of HSP27 during development and decay of thermotolerance in Chinese hamster cells

1991 • 150 citations

Increased expression of epidermal fatty acid binding protein, cofilin, and 14-3-3-σ (stratifin) detected by two-dimensional gel electrophoresis, mass spectrometry and microsequencing of drug-resistant human adenocarcinoma of the pancreas

1999 • 148 citations

Glycoprotein folding in the endoplasmic reticulum: a tale of three chaperones?

2000 • 147 citations

Interaction of heat-shock protein 70 with p53 translated in vitro: evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation.

1992 • 142 citations

The CREC family, a novel family of multiple EF‐hand, low‐affinity Ca²⁺‐binding proteins localised to the secretory pathway of mammalian cells

2000 • 140 citations

Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.

1995 • 139 citations

Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain.

1991 • 134 citations

Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters

2000 • 133 citations

Heat shock proteins in human cancer

2000 • 131 citations

Annexin I is a stress protein induced by heat, oxidative stress and a sulfhydryl‐reactive agent

2000 • 128 citations

Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology.

1996 • 120 citations

Evidence for two states of thermotolerance in mammalian cells

1988 • 107 citations

Calreticulin, a multifunctional Ca<sup>2+</sup> binding chaperone of the endoplasmic reticulum

1998 • 99 citations

Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells

1998 • 96 citations

The relationship of heat-shock proteins, thermotolerance, and protein synthesis

1988 • 92 citations

Calreticulin

1998 • 90 citations

Expression of cyclins and cyclin dependent kinases in human benign and malignant melanocytic lesions

2001 • 89 citations

The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif.

1994 • 83 citations

Modulation of Cell Death Pathways to Apoptosis and Necrosis of H2O2-Treated Rat Thymocytes by Lipocortin I

1996 • 73 citations

Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells

1991 • 67 citations

Calnexin, Calreticulin, and Bip/Kar2p in Protein Folding

1995 • 67 citations

Enhanced expression of human ABC‐transporter tap is associated with cellular resistance to mitoxantrone

2001 • 64 citations

Selective protection by hsp 70 against cytotoxic drug‐, but not Fas‐induced T‐cell apoptosis

1999 • 54 citations

Human melanoma cell lines selected in vitro displaying various levels of drug resistance against cisplatin, fotemustine, vindesine or etoposide: modulation of proto-oncogene expression.

1998 • 53 citations

Search for novel proteins involved in the development of chemoresistance in colorectal cancer and fibrosarcoma cellsin vitro using two-dimensional electrophoresis, mass spectrometry and microsequencing

1999 • 51 citations

Thermosensitivity of multidrug-resistant human gastric and pancreatic carcinoma cells

2000 • 45 citations

Isolation and initial characterization of thermoresistant RIF tumor cell strains.

1988 • 38 citations

Calnexin family members as modulators of genetic diseases

1999 • 37 citations

The Upstream Regulatory Region of the Carbamoyl-phosphate Synthetase I Gene Controls Its Tissue-specific, Developmental, and Hormonal Regulation in Vivo

1996 • 33 citations

Identification of the Ca2+-Binding Domains in Reticulocalbin, an Endoplasmic Reticulum Resident Ca2+-Binding Protein with Multiple EF-Hand Motifs

1997 • 30 citations

Automated Trichloroacetic Acid Precipitation Method for Urine Total Protein

1987 • 27 citations

Association of genomic imbalances with resistance to therapeutic drugs in human melanoma cell lines

1999 • 27 citations

Preoperative Treatment of Rectal Cancer with Radiation, Chemotherapy and Hyperthermia: Analysis of Treatment Efficacy and Heat-Shock Response

1999 • 27 citations

Regulation of the Synthesis of Heat-Shock Proteins in Heat-Resistant Variants of Chinese Hamster Fibroblasts

1988 • 12 citations

Evolutionary malignant resistance of cells to damaging factors as common biological defence mechanism in neoplastic development. Review of conception.

2000 • 11 citations

Heat Resistance in Mammalian Cells: Lessons and Challengesa

1998 • 11 citations

Characterization of an hsp70 related clone encoding a 33 kDa protein with homology to a protein which associates with polysomes

1996 • 6 citations