Suppression of Ras-Induced Apoptosis by the Rac GTPase

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

1997 • 605 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

Ras signalling and apoptosis

1998 • 559 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Rho GTPases

1998 • 534 citations

Apoptosis: Activate NF-κB or die?

1997 • 524 citations

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1994 • 455 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

1996 • 414 citations

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases

1996 • 385 citations

Ras Promotes Cell Survival in Drosophila by Downregulating hid Expression

1998 • 378 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation

1996 • 350 citations

rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation

1996 • 337 citations

Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues

1998 • 295 citations

RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase

1996 • 264 citations

転写因子NF‐κBとAP‐1の活性化に及ぼすチオレドキシンと抗酸化剤の異なった効果

1994 • 259 citations

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

1994 • 214 citations

A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappa B signalling pathways

1998 • 208 citations

A Rac1 Effector Site Controlling Mitogenesis through Superoxide Production

1998 • 187 citations

[14] Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-κB

1994 • 168 citations

Ras effectors and their role in mitogenesis and oncogenesis

1997 • 167 citations

Rac “Insert Region” Is a Novel Effector Region That Is Implicated in the Activation of NADPH Oxidase, but Not PAK65

1996 • 151 citations

The Cat and Mouse Games That Genes, Viruses, and Cells Play

1997 • 138 citations

Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2.

1995 • 133 citations

Mitogen-activated Protein Kinase Phosphatases Inactivate Stress-activated Protein Kinase Pathways in Vivo

1997 • 132 citations

Synergy between the Mos/Mitogen-Activated Protein Kinase Pathway and Loss of p53 Function in Transformation and Chromosome Instability

1997 • 119 citations

Protein Kinase B Activation and Lamellipodium Formation Are Independent Phosphoinositide 3-Kinase-Mediated Events Differentially Regulated by Endogenous Ras

1998 • 104 citations

Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli

1998 • 100 citations

Protein Kinase B and Rac Are Activated in Parallel within a Phosphatidylinositide 3OH-kinase-controlled Signaling Pathway

1998 • 88 citations

Overexpression of mos oncogene product in Swiss 3T3 cells induces apoptosis preferentially during S-phase.

1995 • 31 citations