Current status of the molecular mechanisms of anticancer drug-induced apoptosis

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Control of apoptosis and mitotic spindle checkpoint by survivin

1998 • 1,881 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

1998 • 1,243 citations

Apoptotic Pathways

1998 • 1,193 citations

Bcl-2 family proteins

1998 • 1,055 citations

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

2000 • 994 citations

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1998 • 985 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

Apoptotic DNA Fragmentation

2000 • 885 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53

2002 • 789 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer.

1998 • 720 citations

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases

1998 • 692 citations

Regulation of apoptosis at cell division by p34 ^cdc2 phosphorylation of survivin

2000 • 606 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

1999 • 595 citations

Expression of survivin and its relationship to loss of apoptosis in breast carcinomas

2000 • 561 citations

The EGFR as a target for anticancer therapy—focus on cetuximab

2001 • 540 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells.

2001 • 516 citations

HSP27 inhibits cytochrome c‐dependent activation of procaspase‐9

1999 • 496 citations

A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy.

2000 • 491 citations

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

2000 • 487 citations

Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas.

1998 • 473 citations

Akt Regulates Cell Survival and Apoptosis at a Postmitochondrial Level

2000 • 469 citations

Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

2001 • 466 citations

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

2000 • 447 citations

Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

1999 • 418 citations

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2

2000 • 393 citations

Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways

2001 • 387 citations

Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.

2001 • 366 citations

Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells

2001 • 360 citations

VDAC regulation by the Bcl-2 family of proteins

2000 • 323 citations

Cancer gene therapy using a survivin mutant adenovirus

2001 • 302 citations

Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis.

2001 • 297 citations

Inhibition of melanoma tumor growth in vivo by survivin targeting

2001 • 290 citations

Mechanisms of Transcriptional Activation of bcl-2 Gene Expression by 17β-Estradiol in Breast Cancer Cells

1999 • 253 citations

Apoptosis in the absence of caspase 3

2001 • 231 citations

Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

2001 • 222 citations

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

1996 • 217 citations

Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis.

2000 • 216 citations

Structural basis for the activation of human procaspase-7

2001 • 213 citations

c-Jun NH2-terminal Kinase-mediated Activation of Interleukin-1β Converting Enzyme/CED-3-like Protease during Anticancer Drug-induced Apoptosis

1997 • 207 citations

Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases.

1997 • 207 citations

Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis.

1995 • 200 citations

ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression

2001 • 194 citations

p53 and chemosensitivity

1999 • 181 citations

The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis.

2000 • 179 citations

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-κB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

2001 • 166 citations

High expression levels of nuclear factor κB, IκB kinase α and Akt kinase in squamous cell carcinoma of the oral cavity

2001 • 160 citations

A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells.

2000 • 156 citations

Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2.

1999 • 132 citations

A Role for Mitochondrial Bak in Apoptotic Response to Anticancer Drugs

2001 • 124 citations

Inhibition of the NF-κB transcription factor increases Bax expression in cancer cell lines

2001 • 122 citations

NF-κB activation results in rapid inactivation of JNK in TNFα-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB

2001 • 121 citations

Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance

2001 • 120 citations

BID-dependent and BID-independent pathways for BAX insertion into mitochondria

2000 • 108 citations

Prevention of phosphatidylinositol 3'-kinase-Akt survival signaling pathway during topotecan-induced apoptosis.

2000 • 95 citations

Increased survivin transcript levels: An independent negative predictor of survival in soft tissue sarcoma patients

2001 • 89 citations

Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells

2000 • 87 citations

Determinants of the Nuclear Localization of the Heterodimeric DNA Fragmentation Factor (Icad/Cad)

2000 • 87 citations

NF-κB–mediated chemoresistance in breast cancer cells

2001 • 76 citations

Expression of survivin mRNA and protein in gastric cancer cell line (MKN-45) during cisplatin treatment.

2002 • 73 citations

ANTISENSE INHIBITION OF THE 27 kDa HEAT SHOCK PROTEIN PRODUCTION AFFECTS GROWTH RATE AND CYTOSKELETAL ORGANIZATION IN MCF‐7 CELLS

1996 • 72 citations

Human inhibitor of apoptosis protein (IAP)survivinparticipates in regulation of chromosome segregation and mitotic exit

2001 • 69 citations

Participation of Survivin in mitotic and apoptotic activities of normal and tumor‐derived cells*

2001 • 69 citations

IκB Kinase Activation Is Involved in Regulation of Paclitaxel-Induced Apoptosis in Human Tumor Cell Lines

2002 • 64 citations

A role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanes

2001 • 63 citations

Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis.

2001 • 57 citations

In Acute Myeloid Leukemia only the Coexpression of at Least Two Proteins Including P-Glycoprotein, the Multidrug Resistance-Related Protein MRP, bcl-2, Mutant p53 and Heat-Shock Protein 27 is Predictive for the Response to Induction Chemotherapy

1998 • 44 citations

Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells

2000 • 41 citations

HER2/neu antisense targeting of human breast carcinoma

2000 • 38 citations

BAD partly reverses paclitaxel resistance in human ovarian cancer cells

1998 • 36 citations

TRAIL and inhibitors of apoptosis are opposing determinants for NF-κB-dependent, genotoxin-induced apoptosis of cancer cells

2002 • 33 citations

Expression ofbcl-2 in testicular carcinoma

1998 • 32 citations

S phase dependence and involvement of NF-kappaB activating kinase to NF-kappaB activation by camptothecin22Abbreviations: ALLN, N-acetyl-leu-leu-norleucinal; AT, ataxia telangiectasia; CHX, cycloheximide; CPT, camptothecin; IκB, inhibitor kappa B; IKK, IκB kinase; MEKK1, mitogen-activated protein/ERK kinase kinase 1; NF-κB, nuclear factor kappa B; NIK, NF-κB-inducing kinase; P-IκBα, phosphorylated IκBα, and TNFα, tumor necrosis factor-α.

2001 • 24 citations

Effect of inhibitors of cysteine and serine proteases in anticancer drug-induced apoptosis in gastric cancer cells

2001 • 22 citations

An analysis of the therapeutic efficacy of protracted infusion of low-dose 5-fluorouracil and cisplatin in advanced gastric cancer

2000 • 21 citations

Enhancement of antitumor effect by intratumoral administration of bax gene in combination with anticancer drugs in gastric cancer

2001 • 20 citations

Enhancement of chemotherapeutic agents induced-apoptosis associated with activation of c-Jun N-terminal kinase 1 and caspase 3 (CPP32) in bax-transfected gastric cancer cells.

2000 • 19 citations

Activation and the interaction of proapoptotic genes in modulating sensitivity to anticancer drugs in gastric cancer cells.

1999 • 15 citations

Correlation of Bcl-2 with P-Glycoprotein Expression in Chronic Lymphocytic Leukaemia and Other Haematological Neoplasms but of Neither Marker withEx VivoChemosensitivity or Patient Survival

1996 • 12 citations

A pitfall in the survival benefit of adjuvant chemotherapy for node- and hormone receptor-positive patients with breast cancer: The paradoxical role of Bcl-2 oncoprotein (Review)

2001 • 5 citations