Signal transduction by the neutrophin receptors

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Functions of the neurotrophins during nervous system development: What the knockouts are teaching us

1994 • 1,431 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Intracellular Signaling Pathways Activated by Neuropathic Factors

1996 • 958 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

p75 and Trk: A two-receptor system

1995 • 861 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75

1996 • 768 citations

Induction of cell death by endogenous nerve growth factor through its p75 receptor

1996 • 750 citations

PC12 Pheochromocytoma Cultures in Neurobiological Research

1982 • 728 citations

Association between High Levels of Expression of the TRK Gene and Favorable Outcome in Human Neuroblastoma

1993 • 698 citations

Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

1994 • 583 citations

Neurotrophic factors and their receptors

1995 • 583 citations

Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses

1994 • 538 citations

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

1993 • 525 citations

Neurotrophin signal transduction by the Trk receptor

1994 • 511 citations

Expression and function of TRK-B and BDNF in human neuroblastomas.

1994 • 423 citations

Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells

1994 • 397 citations

The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development.

1994 • 371 citations

p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells

1994 • 353 citations

Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells

1993 • 332 citations

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

1994 • 332 citations

Nerve growth factor and its low-affinity receptor promote Schwann cell migration.

1994 • 319 citations

Early events in neurotrophin signalling via Trk and p75 receptors

1995 • 314 citations

Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling

1997 • 294 citations

The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins

1994 • 294 citations

Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.

1993 • 292 citations

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1994 • 291 citations

Neurotrophins Induce Sphingomyelin Hydrolysis

1995 • 245 citations

Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.

1994 • 244 citations

NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat

1989 • 243 citations

Survival of Cholinergic Forebrain Neurons in Developing p75 ^NGFR -Deficient Mice

1996 • 227 citations

Coexpression of messenger RNA for TRK protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis.

1993 • 208 citations

Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells.

1995 • 196 citations

Lack of High-Affinity Nerve Growth Factor Receptors in Aggressive Neuroblastomas

1993 • 189 citations

Neurotrophins Stimulate the Release of Dopamine from Rat Mesencephalic Neurons via Trk and p75Lntr Receptors

1996 • 187 citations

NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin D1

1995 • 177 citations

Mitogen-activated Protein Kinase-independent Pathways Mediate the Effects of Nerve Growth Factor and cAMP on Neuronal Survival

1996 • 176 citations

NGF and Neurotrophin-3 Both Activate TrkA on Sympathetic Neurons but Differentially Regulate Survival and Neuritogenesis

1997 • 173 citations

Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis

1995 • 147 citations

Characterization of TrkB Receptor‐Mediated Signaling Pathways in Rat Cerebellar Granule Neurons: Involvement of Protein Kinase C in Neuronal Survival

1995 • 144 citations

Autophosphorylation of Activation Loop Tyrosines Regulates Signaling by the TRK Nerve Growth Factor Receptor

1997 • 140 citations

Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos

1994 • 133 citations

Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons.

1993 • 122 citations

Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA.

1993 • 122 citations

Regulation of nerve growth factor receptor gene expression by nerve growth factor in the developing peripheral nervous system.

1991 • 121 citations

Nerve Growth Factor Induces Apoptosis in Human Medulloblastoma Cell Lines that Express TrkA Receptors

1997 • 117 citations

Mitogen-Activated Protein Kinase Activation Is Insufficient for Growth Factor Receptor-Mediated PC12 Cell Differentiation

1995 • 107 citations

N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway.

1996 • 104 citations

Inhibition of p42 and p44 Mitogen‐Activated Protein Kinase Activity by PD98059 Does Not Suppress Nerve Growth Factor‐Induced Survival of Sympathetic Neurones

1996 • 100 citations

Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo.

1993 • 93 citations

Interaction with TrkA Immobilizes gp75 in the High Affinity Nerve Growth Factor Receptor Complex

1995 • 91 citations

Raf, but Not MEK or ERK, Is Sufficient for Differentiation of Hippocampal Neuronal Cells

1996 • 89 citations

Neutralizing Anti‐p21^ras Fabs Suppress Rat Sympathetic Neuron Survival Induced by NGF, LIF, CNTF and cAMP

1995 • 89 citations

Association of neurotrophin receptor expression and differentiation in human neuroblastoma.

1995 • 83 citations

Expression of mRNA for the neurotrophin receptor trkC in neuroblastomas with favourable tumour stage and good prognosis

1996 • 82 citations

Neurotrophin‐3 and Brain‐Derived Neurotrophic Factor Activate Multiple Signal Transduction Events but Are Not Survival Factors for Hippocampal Pyramidal Neurons

1996 • 71 citations

Brain-derived neurotrophic factor protects neuroblastoma cells from vinblastine toxicity.

1996 • 66 citations

The neurotrophin receptor, gp75, forms a complex with the receptor tyrosine kinase TrkA.

1996 • 65 citations

Nerve Growth Factor Stimulates Tyrosine Phosphorylation and Activation of Src Homology-containing Protein-tyrosine Phosphatase 1 in PC12 Cells

1995 • 54 citations

Phosphotyrosine Residues in the Nerve‐Growth‐Factor Receptor (Trk‐A)

1995 • 50 citations

Induction of L1 mRNA in PC12 cells by NGF is modulated by cell-cell contact and does not require the high-affinity NGF receptor

1995 • 33 citations

Nerve growth factor-stimulated mitogen-activated protein kinase activity is not necessary for neurite outgrowth of chick dorsal root ganglion sensory and sympathetic neurons

1996 • 31 citations

p21 Signaling Is Necessary but Not Sufficient to Mediate Neurotrophin Induction of Calcium Channels in PC12 Cells

1996 • 29 citations

TrkA expression decreases the in vivo aggressiveness of C6 glioma cells.

1997 • 22 citations

Prognostic value of TrkA protein detection by monoclonal antibody 5C3 in neuroblastoma.

1996 • 15 citations

Dissociation of NGF Induced Signal Transduction from Neurite Elongation by Expression of a Mutant Adaptor Protein v-Crk in PC12 Cells

1996 • 13 citations

Chapter 3 Nerve growth factor and neuronal gene expression

1994 • 7 citations