p21 Signaling Is Necessary but Not Sufficient to Mediate Neurotrophin Induction of Calcium Channels in PC12 Cells

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons

1989 • 667 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses

1994 • 538 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1994 • 455 citations

Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line

1977 • 395 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1994 • 291 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

1987 • 267 citations

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.

1991 • 255 citations

Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules

1994 • 242 citations

Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras.GTP complex in rat pheochromocytoma PC12 cells.

1992 • 185 citations

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

1994 • 182 citations

Differential effects of NGF, FGF, EGF, cAMP, and dexamethasone on neurite outgrowth and sodium channel expression in PC12 cells

1990 • 181 citations

The trk family of tyrosine protein kinase receptors

1991 • 170 citations

A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction

1995 • 170 citations

v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1995 • 151 citations

Differential expression by nerve growth factor of two types of Ca2+ channels in rat phaeochromocytoma cell lines.

1990 • 145 citations

The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.

1994 • 141 citations

Selective induction of brain type II Na+ channels by nerve growth factor.

1988 • 139 citations

A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions.

1993 • 137 citations

A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth.

1994 • 132 citations

Nerve growth factor acts through cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells

1990 • 120 citations

Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways

1993 • 117 citations

Regulation of ionic currents in pheochromocytoma cells by nerve growth factor and dexamethasone

1989 • 110 citations

Mitogen-Activated Protein Kinase Activation Is Insufficient for Growth Factor Receptor-Mediated PC12 Cell Differentiation

1995 • 107 citations

Nerve growth factor modulates the drug sensitivity of neurotransmitter release from PC-12 cells.

1986 • 84 citations

Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways.

1994 • 79 citations

The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells.

1992 • 59 citations

Enhanced expression of Ca2+ channels by nerve growth factor and the v‐src oncogene in rat phaeochromocytoma cells.

1993 • 41 citations

Fibroblast growth factor‐induced increases in calcium currents in the PC12 pheochromocytoma cell line are tyrosine phosphorylation dependent

1994 • 29 citations

Rapid Communication: ras‐Independent Induction of Rat Brain Type II Sodium Channel Expression in Nerve Growth Factor‐Treated PC 12 Cells

1993 • 27 citations

Inhibition of protein kinases in rat pheochromocytoma (PC12) cells promotes morphological differentiation and down-regulates ion channel expression

1992 • 21 citations