Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

ras GENES

1987 • 3,818 citations

The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain

1959 • 2,294 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM

1960 • 692 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

1989 • 624 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

Purification of the Chick Eye Ciliary Neuronotrophic Factor

1984 • 519 citations

K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.

1992 • 496 citations

Brain-derived neurotrophic factor prevents neuronal death in vivo

1988 • 490 citations

Oncogenes in solid human tumours

1982 • 467 citations

Purification, Cloning, and Expression of Ciliary Neurotrophic Factor (CNTF)

1989 • 429 citations

Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain

1987 • 421 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro

1963 • 417 citations

Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor

1985 • 384 citations

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

1988 • 343 citations

Growth factor signaling: Where is the specificity?

1992 • 341 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site.

1986 • 287 citations

Expression of ras proto-oncogene proteins in normal human tissues.

1987 • 216 citations

Cell death of motoneurons in the chick embryo spinal cord

1984 • 203 citations

ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons

1989 • 192 citations

[74] Microinjection of early SV40 DNA fragments and T antigen

1980 • 176 citations

Cell death of motoneurons in the chick embryo spinal cord. VI. Reduction of naturally occurring cell death in the thoracolumbar column of terni by nerve growth factor

1982 • 147 citations

Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo

1988 • 142 citations

Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase

1992 • 129 citations

Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins

1986 • 65 citations

Both nerve growth factor and high K+ concentrations support the survival of chick embryo sympathetic neurons Evidence for a common mechanism of action

1983 • 61 citations

Effect of a Dominant Inhibitory Ha-ras Mutation on Neuronal Differentiation of PC12 Cells

1990 • 58 citations

Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons

1990 • 52 citations

ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells.

1991 • 48 citations

Isoelectric focusing of the chick eye ciliary neuronotrophic factor

1982 • 19 citations

Ras protein expression is developmentally regulated in embryonic chicken brain

1989 • 3 citations