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Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

The Neural Crest

1999 • 2,996 citations

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

1973 • 1,284 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

Association between High Levels of Expression of the TRK Gene and Favorable Outcome in Human Neuroblastoma

1993 • 698 citations

Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

1985 • 644 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

IN SITU NEUROBLASTOMAS: A CONTRIBUTION TO THE NATURAL HISTORY OF NEURAL CREST TUMORS.

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Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells

1993 • 332 citations

The nerve growth factor family

1990 • 326 citations

Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation

1992 • 321 citations

Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor

1991 • 294 citations

K‐252 Compounds: Modulators of Neurotrophin Signal Transduction

1992 • 248 citations

Regulation of neurotrophin receptors during the maturation of the mammalian visual system

1994 • 233 citations

Coexpression of messenger RNA for TRK protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis.

1993 • 208 citations

Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation

1994 • 207 citations

Lack of High-Affinity Nerve Growth Factor Receptors in Aggressive Neuroblastomas

1993 • 189 citations

A review of 17 IV-S neuroblastoma patients at the children's hospital of Philadelphia

1980 • 177 citations

The trk family of tyrosine protein kinase receptors

1991 • 170 citations

Cancer Invasion and Metastases

1990 • 136 citations

Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA.

1993 • 122 citations

Maturation of sympathicoblastoma into ganglioneuroma.Report of 2 patients with 20- and 46-year survivals respectively

1959 • 108 citations

Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo.

1993 • 93 citations

Brain-derived neurotrophic factor stimulates survival and neuronal differentiation in cultured avian neural crest

1988 • 78 citations

trk and ret proto‐oncogene expression in human neuroblastoma specimens: High frequency of trk expression in non‐advanced stages

1993 • 78 citations

Multiple defects of the nerve growth factor receptor in human neuroblastomas.

1990 • 78 citations

Analysis of nerve growth factor receptor expression in human neuroblastoma and neuroepithelioma cell lines.

1989 • 62 citations

The expression of multiple proto-oncogenes is differentially regulated during retinoic acid induced maturation of human neuroblastoma cell lines.

1988 • 58 citations

Neurotrophic Factors: What Are They and What Are They Doing?

1993 • 48 citations

Selective Inhibition of Nerve Growth Factor‐Stimulated Protein Kinases by K‐252a and 5′‐S‐Methyladenosine in PC12 Cells

1989 • 45 citations