Prospects for applying genotypic selection of somatic oncomutation to chemical risk assessment

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1991 • 8,133 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1998 • 998 citations

p53 and Human Cancer: The First Ten Thousand Mutations

1999 • 968 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES

1986 • 884 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis

1990 • 773 citations

Molecular Assessment of Histopathological Staging in Squamous-Cell Carcinoma of the Head and Neck

1995 • 759 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

Role of the p16 tumor suppressor gene in cancer.

1998 • 710 citations

Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin

1997 • 702 citations

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

1993 • 656 citations

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1988 • 620 citations

Resequencing and mutational analysis using oligonucleotide microarrays

1999 • 517 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

1998 • 474 citations

Beta-catenin mutations in human prostate cancer.

1998 • 368 citations

Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With Early Stage Lung Cancer

1999 • 349 citations

A Cancer Risk Assessment of Di(2-ethylhexyl)phthalate: Application of the New U.S. EPA Risk Assessment Guidelines

1999 • 330 citations

UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement.

1994 • 324 citations

High frequency of Ki‐ras codon 12 mutations in pancreatic adenocarcinomas

1989 • 295 citations

Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease

1996 • 290 citations

APC Mutations in Sporadic Medulloblastomas

2000 • 283 citations

Geographic Variation of p53 Mutational Profile in Nonmalignant Human Liver

1994 • 282 citations

Human Gene Mutation Database?A biomedical information and research resource

2000 • 278 citations

Activation of ras Oncogenes Preceding the Onset of Neoplasia

1990 • 261 citations

Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.

1999 • 261 citations

The ‘A rule’ of mutagen specificity: A consequence of DNA polymerase bypass of non‐instructional lesions?

1991 • 260 citations

The p53-deficient mouse: a model for basic and applied cancer studies

1996 • 256 citations

Molecular detection of genetic alterations in the serum of colorectal cancer patients.

1998 • 240 citations

Working paper no. 3 Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo

1994 • 234 citations

Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array

1999 • 233 citations

Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites

1994 • 228 citations

β-Catenin Expression Pattern in Stage I and II Ovarian Carcinomas

1999 • 225 citations

Restricted ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum cells.

1986 • 215 citations

Other transgenic mutation assays: A new transgenic mouse mutagenesis test system using Spi− and 6-thioguanine selections

1996 • 210 citations

Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors.

1998 • 204 citations

Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vector

1991 • 197 citations

Human DNA repair systems: An overview

1999 • 196 citations

IARC p53 mutation database: A relational database to compile and analyze p53 mutations in human tumors and cell lines

1999 • 186 citations

Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers

1998 • 174 citations

Activation of β-catenin in epithelial and mesenchymal hepatoblastomas

2000 • 169 citations

Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers

1998 • 167 citations

Detection of K-ras mutations in lung carcinomas: Relationship to prognosis

1996 • 166 citations

K-ras activation in premalignant and malignant epithelial lesions of the human uterus.

1991 • 163 citations

ICH-Harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact

1999 • 160 citations

Somatic Mutations Are Frequent and Increase with Age in Human Kidney Epithelial Cells

1996 • 155 citations

Carcinogenesis in mouse and human cells: parallels and paradoxes

2000 • 154 citations

Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice

1994 • 153 citations

Use of supF, an Escherichia coli tyrosine suppressor tRNA gene, as a mutagenic target in shuttle-vector plasmids

1989 • 150 citations

Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis.

2000 • 148 citations

The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium

1999 • 147 citations

Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma

1994 • 142 citations

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

1994 • 141 citations

Mutational analysis using oligonucleotide microarrays

1999 • 137 citations

K-ras activation in neoplasms of the human female reproductive tract.

1990 • 130 citations

p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment.

1996 • 130 citations

High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.

1998 • 129 citations

Genotypic selection methods for the direct analysis of point mutations

1997 • 127 citations

Mutation of β-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis

1999 • 125 citations

Validation studies with Muta™ mouse: A transgenic mouse model for detecting mutations in vivo

1991 • 120 citations

Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea.

1992 • 117 citations

Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing.

1993 • 114 citations

Molecular aspects of chemical carcinogenesis: The roles of oncogenes and tumour suppressor genes

1995 • 110 citations

Concurrent mutations of coding and regulatory sequences of the Ha-ras gene in urinary bladder carcinomas

1992 • 110 citations

The Natural Somatic Mutation Frequency and Human Carcinogenesis

1997 • 103 citations

Mutations of the β‐Catenin Gene in Endometrial Carcinomas

1999 • 99 citations

The tumor suppressor protein p53

1995 • 98 citations

The Molecular Epidemiology of Lung Cancer

1997 • 97 citations

UV-Radiation-Specific p53 Mutation Frequency in Normal Skin as a Predictor of Risk of Basal Cell Carcinoma

1998 • 97 citations

A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes

1985 • 97 citations

What do Animal Cancer Tests Tell us About Human Cancer Risk?: Overview of Analyses of the Carcinogenic Potency Database

1998 • 97 citations

The application of in vitro data in the derivation of the Acceptable Daily Intake of food additives

1999 • 93 citations

Induction of 6‐thioguanine‐resistant lymphocytes in fischer 344 rats following in vivo exposure to n‐ethyl‐n‐nitrosourea and cyclophosphamide

1991 • 92 citations

Relative sensitivity of the endogenous hprt gene and lacl transgene in ENU‐treated big blue™ B6C3F1 mice

1995 • 91 citations

Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence.

1999 • 91 citations

Diagnosis of Pancreatic Cancer by Detecting Telomerase Activity in Pancreatic Juice: Comparison With K- Ras Mutations

1999 • 88 citations

Tobacco and cancer: epidemiology and the laboratory.

1995 • 87 citations

Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice.

1996 • 87 citations

Genotypic mutation analysis by RFLP/PCR

1993 • 86 citations

A Comprehensive Approach for Integration of Toxicity and Cancer Risk Assessments

1999 • 81 citations

Fidelity and Mutational Spectrum of Pfu DNA Polymerase on a Human Mitochondrial DNA Sequence

1997 • 81 citations

K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.

1997 • 79 citations

Spontaneous mutation in lacI transgenic mice: a comparison of tissues

1998 • 78 citations

Detection of mutations of p53 tumor suppressor gene in pancreatic juice and its application to diagnosis of patients with pancreatic cancer: comparison with K-ras mutation.

1999 • 78 citations

Molecular analysis of lacI mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene

1994 • 75 citations

Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium.

1992 • 72 citations

Chloroform Mode of Action: Implications for Cancer Risk Assessment

1997 • 72 citations

Spectra ofgpt mutations in ethylnitrosourea-treated and untreated transgenic mice

1999 • 71 citations

Tamoxifen causes gene mutations in the livers of lambda/lacI transgenic rats.

1997 • 70 citations

Marked differences in the role of O6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N-nitrosourea.

1995 • 69 citations

Interplay between heterocyclic amines in cooked meat and metabolic phenotype in the etiology of colon cancer

1996 • 69 citations

Neonatal Mouse Assay for Tumorigenicity: Alternative to the Chronic Rodent Bioassay

1997 • 68 citations

Mutations of the Ki-ras oncogene in endometrial carcinoma

1992 • 68 citations

A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice

1996 • 64 citations

Detection of K-ras Point Mutations at Codon 12 in Pure Pancreatic Juice for the Diagnosis of Pancreatic Cancer by PCR-RFLP Analysis

1996 • 63 citations

Ha-ras gene codon 12 mutation and DNA ploidy in urinary bladder carcinoma

1990 • 62 citations

On the origin of multiple mutations in human cancers

1998 • 62 citations

Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.

1994 • 61 citations

ThecII locus in the Muta?Mouse System

1999 • 61 citations

Mutational spectrometry without phenotypic selection: human mitochondrial DNA

1997 • 60 citations

Development of a transgenic mouse model for carcinogenesis bioassays: evaluation of chemically induced skin tumors in Tg.AC mice

1999 • 59 citations

Species-specific differences in hepatic mutant frequency and mutational spectrum among lambda/lacl transgenic rats and mice following exposure to aflatoxin B₁

1996 • 59 citations

Other transgenic mutation assays:APRT: A versatile in vivo resident reporter of local mutation and loss of heterozygosity

1996 • 58 citations

Stimulating research to improve the scientific basis of risk assessment

1999 • 57 citations

High frequency of codon 61 K-ras A→T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene

1999 • 57 citations

Biological Effect Markers for Exposure to Carcinogenic Compound and Their Relevance for Risk Assessment

1998 • 56 citations

Histologic and biologic patterns of microscopic pancreatic ductal adenocarcinomas detected incidentally at autopsy

1998 • 56 citations

p53 and Ha-ras mutations in chemically induced hamster buccal pouch carcinomas

1996 • 55 citations

Mutagenic potential of alpha-(N2-deoxyguanosinyl)tamoxifen lesions, the major DNA adducts detected in endometrial tissues of patients treated with tamoxifen.

1999 • 54 citations

Increased frequency of mutations at A:T base pairs in the bone marrow of B6C3F1 lacl transgenic mice exposed to 1, 3‐butadiene

1995 • 53 citations

Applications of physiologic pharmacokinetic modeling in carcinogenic risk assessment.

1994 • 51 citations

Mutational spectra in the lacl gene in skin from 7, 12‐dimethylbenz[a]anthracene‐treated and untreated transgenic mice

1995 • 51 citations

ENU-induced mutagenesis at a single A: T base pair in transgenic mice containing Φ X174

1993 • 51 citations

Transition mutations at CpG dinucleotides are the most frequent in vivo spontaneous single-base substitution mutation in the humanHPRT gene

1998 • 50 citations

US Environmental Protection Agency's revised Guidelines for Carcinogen Risk Assessment: incorporating mode of action data

1998 • 49 citations

Analysis of in vivo mutation induced by N‐ethyl‐N‐nitrosourea in the hprt gene of rat lymphocytes

1995 • 46 citations

Roles of transcription and repair in alkylation mutagenesis

1994 • 45 citations

Tk+/− mouse model for detecting in vivo mutation in an endogenous, autosomal gene

1999 • 45 citations

A highly sensitive method for K‐ ras mutation detection is useful in diagnosis of gastrointestinal cancer

1999 • 45 citations

Spontaneous and ENU-induced mutation spectra at the cII locus in Big Blue^® Rat2 embryonic fibroblasts

1998 • 44 citations

H- AND K- ras MUTATIONAL PROFILES IN CHEMICALLY INDUCED LIVER TUMORS FROM B6C3F1 AND CD-1 MICE

1996 • 44 citations

Detection of K-ras and p53 Gene Mutations in Pancreatic Juice for the Diagnosis of Intraductal Papillary Mucinous Tumors

1999 • 44 citations

Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs

1994 • 44 citations

A Unified Approach to Risk Assessment for Cancer and Noncancer Endpoints Based on Benchmark Doses and Uncertainty/Safety Factors1

1999 • 44 citations

Mice over-expressing human O6alkylguanine-DNA alkyltransferase selectively reduce O6methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea

1999 • 44 citations

Frequent mutations of the rat ?-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone

1999 • 43 citations

Carcinogenicity results for 114 laboratory animal studies used to assess the predictivity of four in vitro genetic toxicity assays for rodent carcinogenicity

1990 • 43 citations

High proportion of mutant K-ras gene in pancreatic juice of patients with pancreatic cystic lesions

1999 • 43 citations

Alternatives to the 2-species bioassay for the identification of potential human carcinogens

1996 • 42 citations

Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer.

1997 • 42 citations

Quantitative detection of ultraviolet-specific p53 mutations in normal skin from Japanese patients.

1997 • 41 citations

Mutations in ras genes in experimental tumours of rodents.

1999 • 41 citations

Applications of constant denaturant capillary electrophoresis / high-fidelity polymerase chain reaction to human genetic analysis

1999 • 40 citations

Uncertainty in Cancer Risk Estimates

1993 • 40 citations

Molecular methods for the diagnosis of cancer

1999 • 40 citations

Pancreatic lymph nodal and plexus micrometastases detected by enriched polymerase chain reaction and nonradioisotopic single-strand conformation polymorphism analysis: a new predictive factor for recurrent pancreatic carcinoma.

1997 • 39 citations

TP53 tumour suppressor gene: clues to molecular carcinogenesis and cancer therapy.

1996 • 38 citations

Ras and myelodysplasia: lessons from the last decade.

1996 • 37 citations

Carcinogenesis models for risk assessment

1997 • 37 citations

Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung

1995 • 37 citations

Spectrum of point mutations in the coding region of the hypoxanthine- guanine phosphoribosyltransferase (hprt) gene in human T-lymphocytes in vivo

1998 • 37 citations

An introduction to the use of physiologically based pharmacokinetic models in risk assessment

1997 • 36 citations

How useful are chronic (life-span) toxicology studies in rodents in identifying pharmaceuticals that pose a carcinogenic risk to humans?

1993 • 36 citations

Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats

1998 • 35 citations

A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA

2000 • 35 citations

AT base pairs are the main target for mutations at the hprt locus of rat skin fibroblasts exposed in vitro to the monofunctional alkylating agent N-ethyl-N-nitrosourea

1994 • 35 citations

Detection of Infrequent and Multiple K-rasMutations in Human Tumors and Tumor-Adjacent Tissues

1997 • 34 citations

Induction of hprt gene mutations in splenic T-lymphocytes from the rat exposed in vivo to DNA methylating agents is correlated with formation of O⁶-methylguanine in bone marrow and not in the spleen

1996 • 33 citations

Tamoxifen induces G:C->T:A mutations in the cII gene in the liver of lambda/lacI transgenic rats but not at 5'-CpG-3' dinucleotide sequences as found in the lacI transgene

1999 • 33 citations

Comparison of the mutations at Hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene or the racemic mixture of 1,2:3,4-diepoxybutane

2000 • 33 citations

Kinds and locations of mutations induced in the hypoxanthine-guanine phosphoribosyltransferase gene of human T-lymphocytes by 1-nitrosopyrene, including those caused by V(D)J recombinase.

1994 • 33 citations

Molecular analysis of in vivo mutations induced byN-ethyl-N-nitrosourea in the autosomalTk and the X-linkedHprt genes of mouse lymphocytes

1999 • 33 citations

Needle-in-a-haystack detection and identification of base substitution mutations in human tissues

1999 • 32 citations

Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation

1998 • 32 citations

In vivo loss of heterozygosity in T-cells of B6C3F1Aprt+/? mice

2000 • 32 citations

Somatic cell mutations in cancer epidemiology.

1997 • 31 citations

β‐Catenin (Ctnnb1) Gene Mutations in Diethylnitrosamine (DEN)‐induced Liver Tumors in Male F344 Rats

1999 • 29 citations

Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats

1998 • 29 citations

DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene

1996 • 29 citations

Regulatory Cancer Risk Assessment Based on a Quick Estimate of a Benchmark Dose Derived from the Maximum Tolerated Dose

1998 • 29 citations

Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to 238Pu alpha-particles in human bronchial epithelial cells

1997 • 29 citations

Principles for the selection of doses in chronic rodent bioassays. ILSI Risk Science Working Group on Dose Selection.

1997 • 28 citations

The in vivo mutagenicity and mutational spectrum at the lacI transgene recovered from the spleens of B6C3F1 lacI transgenic mice following a 4-week inhalation exposure to 1,3-butadiene

1998 • 28 citations

MOLECULAR PATHOGENESIS OF COLORECTAL CANCER

1997 • 28 citations

Detection of basepair substitution mutation at a frequency of 1 × 10−7 by combining two genotypic selection methods, MutEx enrichment and allele-specific competitive blocker PCR

1998 • 28 citations

Allele-specific PCR analysis ofp53 codon 249 AGT transversion in liver tissues from patients with viral hepatitis

1996 • 28 citations

Other transgenic mutation assays: Tissue specificity of spontaneous point mutations in λsupF transgenic mice

1996 • 28 citations

Multiple K‐ras Mutations in Hyperplasia and Carcinoma in Cases of Human Pancreatic Carcinoma

1999 • 27 citations

Mutations of the Ki-ras protooncogene in 3-methylcholanthrene and urethan-induced and butylated hydroxytoluene-promoted lung tumors of strain A/J and SWR mice

1995 • 26 citations

Detection of Low-Frequency Mutations in Exon 8 of the TP53 Gene by Constant Denaturant Capillary Electrophoresis (CDCE)

1999 • 26 citations

Detection of a mouse H-ras codon 61 mutation using a modified allele-specific competitive blocker PCR genotypic selection method

1998 • 25 citations

SMOKING AND THE MOLECULAR EPIDEMIOLOGY OF LUNG CANCER

2000 • 24 citations

p53 Gene Mutation and Loss of Heterozygosity of Chromosome 11 in Methylcholanthrene‐induced Mouse Sarcomas

1998 • 24 citations

Hprt mutant frequency and molecular analysis of Hprt mutations in Fischer 344 rats treated with thiotepa

1999 • 24 citations

The use of biochemical and molecular parameters to estimate dose-response relationships at low levels of exposure.

1998 • 23 citations

DNA sequence analysis of 1-nitrosopyrene-induced mutations in the hprt gene of Chinese hamster ovary cells

1992 • 22 citations

The restriction site mutation assay: a review of the methodology development and the current status of the technique

1999 • 22 citations

Oncogenic base substitution mutations in circulating leukocytes of normal individuals.

2000 • 22 citations

Identification and quantification of a carcinogen-induced molecular initiation event in cell transformation.

1992 • 22 citations

Mutation analysis using the restriction site mutation (RSM) assay

1998 • 22 citations

Ultraviolet b light‐induced mutagenesis of p53 hotspot codons 248 and 249 in human skin fibroblasts

1994 • 21 citations

Oxazepam is mutagenic in vivo in Big Blue(R) transgenic mice

1999 • 21 citations

K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa

1998 • 21 citations

Transcription coupled repair and its impact on mutagenesis

1998 • 21 citations

Enrichment polymerase chain reaction for the detection of Ki- ras mutations: relevance of Taq polymerase error rate, initial DNA copy number, and reaction conditions on the emergence of false-positive mutant bands

1999 • 20 citations

Implementation of EPA Revised Cancer Assessment Guidelines: Incorporation of Mechanistic and Pharmacokinetic Data

1997 • 20 citations

Mutagenic Specificity ofN-Methyl-N′-nitro-N-nitrosoguanidine in thetonBGene on the Chromosome ofEscherichia coli recA+andrecA−Cells

1996 • 20 citations

Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.

1999 • 20 citations

Mutation spectrum of 4-nitroquinoline N-oxide in the lacI transgenic Big Blue® Rat2 cell line

1999 • 20 citations

Correlated mutagenesis ofbcl2 andhprt loci in blood lymphocytes

1997 • 19 citations

Development and applications of mutational spectra technology

1994 • 18 citations

Of mice and mutants: target size and sensitivity

1995 • 18 citations

Detection of K-ras mutations of bronchoalveolar lavage fluid cells aids the diagnosis of lung cancer in small pulmonary lesions.

1999 • 18 citations

Patterns of genetic alterations in pancreatic cancer: A pooled analysis

1999 • 18 citations

HA-RAS CODON 12 MUTATION IN PAPILLARY TUMORS OF THE URINARY-BLADDER - A RETROSPECTIVE STUDY

1994 • 18 citations

Purpose and guidelines for toxicokinetic studies within the National Toxicology Program.

1997 • 17 citations

Simple and Reliable Factor V Genotyping by PNA-Mediated PCR Clamping

1998 • 17 citations

Development of new molecular procedures for the detection of genetic alterations in man

1996 • 17 citations

A novel sensitive method to detect frameshift mutations in exonic repeat sequences of cancer-related genes

1999 • 17 citations

COMMENTARY: Mutational spectra: from model systems to cancer-related genes

1996 • 16 citations

Molecular analysis of DNA adducts and hprt mutations produced by 6-nitrosochrysene in Chinese hamster ovary cells

1993 • 16 citations

Enhanced restriction site mutation (RSM) analysis of 1,2-dimethylhydrazine induced mutations, using endogenous p53 intron sequences

1997 • 15 citations

Trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene is metabolized to form a major adduct with deoxyguanosine and produces mutations in the hprt gene of Chinese hamster ovary cells at G:C basepairs

1993 • 15 citations

Effect of distamycin on chlorambucil-induced mutagenesis in pZ189: evidence of a role for minor groove alkylation at adenine N-3

1994 • 15 citations

Analysis of K-ras Codon 12 Point Mutations Using Duodenal Lavage Fluid for Diagnosis of Pancreatic Carcinoma

1999 • 14 citations

Gene- and tissue-specificity of mutation in Big Blue® rats treated with the hepatocarcinogenN-hydroxy-2-acetylaminofluorene†

2001 • 14 citations

Quantitative enriched PCR (QEPCR), a highly sensitive method for detection of K-ras oncogene mutation

1997 • 14 citations

Advances in understanding mechanisms of toxicity and implications for risk assessment

1997 • 13 citations

Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene

1997 • 13 citations

Genes and gene products that regulate proliferation and differentiation: critical targets in carcinogenesis.

1992 • 13 citations

Spontaneous mutants recovered from liver and germ cell tissue of low copy number lacI transgenic rats

1996 • 12 citations

Chemicals for evaluating the sensitivity and specificity of reduced/transgenic rodent cancer bioassay protocols

1995 • 12 citations

Molecular analysis of hypoxanthine phosphoribosyl transferase mutants induced by glycidyl 1‐naphthyl ether in mouse spleen cells in vivo

1993 • 12 citations

Alternative tests: carcinogenesis as an example.

1998 • 12 citations

Series: Current issues in mutagenesis and carcinogenesis, No. 43 Mutations among the living and the undead

1994 • 11 citations

The traditional toxicologic paradigm is correct: dose influences mechanism.

1998 • 11 citations

Combined analysis of microsatellite instability and K-ras mutation increases detection incidence of normal samples from colorectal cancer patients.

1997 • 11 citations

Base-substitution profiles of externally activated polycyclic aromatic hydrocarbons and aromatic amines determined in alacZ reversion assay

1999 • 11 citations

Possible factors leading to a misjudgement of mutant frequencies in HPRT assay

1996 • 11 citations

Ethylnitrosourea-induced mutation and molecular analysis of transgenic mice containing the gpt shuttle vector

1999 • 10 citations

Statistical research needs in mechanistic modelling for carcinogenic risk assessment

1997 • 10 citations

Validating New Toxicology Tests for Regulatory Acceptance

1998 • 10 citations

Activation of H-ras-1 Oncogenes by Chemical Carcinogens

1986 • 10 citations

Inverse restriction site mutation (iRSM) analysis. Mutation detection involving the formation of restriction enzyme sites in target genes

1999 • 10 citations

Mutational specificity of aflatoxin B1. Comparison of in vivo host-mediated assay with in vitro S9 metabolic activation

1996 • 9 citations

Restriction site mutation (RSM) analysis of 2-acetylaminofluorene (2-AAF)-induced mouse liver mutations and comparison with the measurement of in vivo micronucleus induction in the bone marrows of (2-AAF)-treated mice

2000 • 9 citations

Genetic Alterations in Colorectal Cancer, Comparative Analysis of Deletion Events, and Point Mutations

1998 • 8 citations

Mutation enhancing effect of o-vanillin in the lacZ gene of Escherichia coli: characterization of mutational spectrum

1993 • 8 citations

U.S. Food and Drug Administration perspective of the inclusion of effects of low-level exposures in safety and risk assessment.

1998 • 7 citations

The early detection of frameshift mutations induced by a food-borne carcinogen in rats: a new tool for molecular epidemiology

2000 • 6 citations

A biologically based pharmacodynamic model for lipid peroxidation stimulated by trichloroethylene in vitro

1999 • 5 citations

Sampling technique influences the detection of K-ras mutations in normal appearing mucosa of colorectal cancer patients.

1999 • 4 citations

Application of the restriction site mutation technique toN-methyl-N-nitrosourea-induced mutations in the rat

1998 • 4 citations

Development of a novel CHL/IU cell line with an incorporated gpt shuttle vector for concurrent analysis of gene mutations and chromosome aberrations

1997 • 4 citations

Activating mutations in human <scp>C</scp>‐Ha‐ras‐1 protooncogene induced by stereoisomeric fjord‐region benzo[c]chrysene diol‐epoxides

1995 • 3 citations

A study of ENU-induced mutagenesis in the mouse using the restriction site mutation (RSM) assay

1999 • 3 citations

An overview of the risk assessment of hazardous materials and the role of toxicology.

1997 • 1 citations