Mutational spectrometry without phenotypic selection: human mitochondrial DNA

MOLECULAR BIOLOGY AND EVOLUTION

2021 • 4,185 citations

Rapid evolution of animal mitochondrial DNA.

1979 • 3,420 citations

High-performance electrophoresis

1985 • 1,509 citations

DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels: correspondence with melting theory.

1983 • 895 citations

A Ligase-Mediated Gene Detection Technique

1988 • 834 citations

Genetic disease detection and DNA amplification using cloned thermostable ligase.

1991 • 803 citations

Allele-specific enzymatic amplification of beta-globin genomic DNA for diagnosis of sickle cell anemia.

1989 • 637 citations

High-fidelity amplification using a thermostable DNA polymerase isolated from Pyrococcus furiosus

1991 • 569 citations

[30] Computational simulation of DNA melting and its application to denaturing gradient gel electrophoresis

1987 • 491 citations

Fidelity of DNA polymerases in DNA amplification.

1989 • 487 citations

ANTENATAL DIAGNOSIS OF SICKLE-CELL ANÆMIA BY D.N.A. ANALYSIS OF AMNIOTIC-FLUID CELLS

1978 • 380 citations

Mismatch amplification mutation assay (MAMA): application to the c-H-ras gene.

1992 • 379 citations

BILATERAL ZOSTER

1947 • 322 citations

Rapid separation and purification of oligonucleotides by high-performance capillary gel electrophoresis.

1988 • 312 citations

Activation of ras Oncogenes Preceding the Onset of Neoplasia

1990 • 261 citations

The ligation amplification reaction (LAR)—Amplification of specific DNA sequences using sequential rounds of template-dependent ligation

1989 • 258 citations

Stabilities of nearest‐neighbor doublets in double‐helical DNA determined by fitting calculated melting profiles to observed profiles

1981 • 238 citations

Occurrence of a Phase Transition in Nucleic Acid Models

1966 • 238 citations

Sequence analysis of cDNAs for the human and bovine ATP synthase ? subunit: mitochondrial DNA genes sustain seventeen times more mutations

1987 • 237 citations

Recursion relation generation of probability profiles for specific‐sequence macromolecules with long‐range correlations

1974 • 225 citations

Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay

1978 • 206 citations

Extensive polymorphism in the mitochondrial DNA of apes.

1981 • 170 citations

Constant denaturant capillary electrophoresis (CDCE): a high resolution approach to mutational anaylsis

1994 • 169 citations

Constant denaturant gel electrophoresis, a modification of denaturing gradient gel electrophoresis, in mutation detection

1991 • 134 citations

Detection of point mutations with a modified ligase chain reaction (Gap-LCR)

1995 • 118 citations

Rate and mode differences between nuclear and mitochondrial small-subunit rRNA genes in mushrooms.

1992 • 116 citations

Molecular analysis of complex human cell populations: mutational spectra of MNNG and ICR-191

1990 • 86 citations

The effect of chemotherapy on the in vivo frequency of glycophorin A ‘null’ variant erythrocytes

1990 • 74 citations

A genotypic mutation system measuring mutations in restriction recognition sequences

1991 • 59 citations

Mutational spectrometry: a general approach for hot-spot point mutations in selectable genes.

1992 • 50 citations

Mutational Spectrometry: Means and Ends

1994 • 27 citations

Potential use of gradient denaturing gel electrophoresis in obtaining mutational spectra from human cells.

1985 • 25 citations

Variance estimation in single-cell mutation assays: comparison to experimental observations in human lymphoblasts at 4 gene loci

1985 • 25 citations

Efficiency of separation of DNA mutations by constant denaturant capillary electrophoresis is controlled by the kinetics of DNA melting equilibrium

1996 • 18 citations

Use of wide‐bore capillaries in constant denaturant capillary electrophoresis

1996 • 14 citations