Multiple K‐ras Mutations in Hyperplasia and Carcinoma in Cases of Human Pancreatic Carcinoma

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

1993 • 656 citations

p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.

1997 • 428 citations

Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation.

1993 • 351 citations

Morphological lesions associated with human primary invasive nonendocrine pancreas cancer.

1976 • 346 citations

Relation of pancreatic duct hyperplasia to carcinoma

1979 • 322 citations

High frequency of Ki‐ras codon 12 mutations in pancreatic adenocarcinomas

1989 • 295 citations

Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease

1996 • 290 citations

Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors.

1991 • 210 citations

Pancreatic Duct Hyperplasia and Cancer

1954 • 180 citations

Total Pancreatectomy for Cancer An appraisal of 65 cases

1977 • 157 citations

Intraductal proliferation in the pancreas and its relationship to human and experimental carcinogenesis

1980 • 156 citations

Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis.

1995 • 153 citations

Further Evaluation of Total Pancreatectomy

1975 • 133 citations

Frequency and Types of Point Mutation at the 12th Codon of the c‐Ki‐ras Gene Found in Pancreatic Cancers from Japanese Patients

1989 • 128 citations

Total pancreatectomy for ductal adenocarcinoma of the pancreas

1981 • 126 citations

Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice

1997 • 115 citations

Detection of Point Mutations in the Kirsten-ras Oncogene Provides Evidence for the Multicentricity of Pancreatic Carcinoma

1993 • 114 citations

Histopathology in the Evaluation of Total Pancreatectomy for Ductal Carcinoma

1979 • 104 citations

Frequent Glycine‐to‐Aspartic Acid Mutations at Codon 12 of c‐Ki‐ras Gene in Human Pancreatic Cancer in Japanese

1990 • 102 citations

Panel: Cancer of the pancreas

1978 • 79 citations

Differences between solid and duct-ectatic types of pancreatic ductal carcinomas

1992 • 75 citations

Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation

1998 • 32 citations

Oxygen derived free radicals in patients with chronic pancreatic and other digestive diseases.

1990 • 29 citations

A Case of Small Pancreatic Cancer Diagnosed by Serial Follow-up Studies Promptly by a Positive K-ras Point Mutation in Pure Pancreatic Juice

1998 • 13 citations

BRANCH DUCT ORIGIN OF SOLID TYPE PANCREATIC DUCTAL CARCINOMA

1993 • 4 citations

Deleted Work

1955 • 0 citations

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